Discussions By Condition: Eye conditions

Treatment options for POHS

Posted In: Eye conditions 2 Replies
  • Posted By: Anonymous
  • April 30, 2006
  • 02:17 AM

I'm not really expecting an answer to this since this is the first post, but what the ***l???

A friend of my father's was recently diagnosed with presumed ocular histoplasmosis syndrome. I'm hoping to go to med school in a couple years and my father asked me to look into it. Prior to today, I knew nothing about it.

The friend is currently scheduled to have photocoagulation and Visudyne treatment on Monday.

When I first started reading about POHS, the first thing I thought when I came across the fact that the vision loss is due to choroidal neovascularization (CNV) was that it would probably be a good candidate for treatment with Avistan.

Avistan is a fairly new cancer drug and its only approved use is for colorectal cancer, but it's an anti-angiogenesis inhibitor, which means it prevents new blood vessels from being created. Neovascularization is simply angiogenesis in the tissues of the eye.

So I did a little more research and found out that there have been some small studies using Avistan to treat age related macular degeneration (ARMD or AMD). AMD appears to operate in more or less the same manner, doing its damage via CNV. The treatment with Avistan has been very promising with about 40% completely reversing the damage, 30% having significant improvement and the rest not getting worse, which is something...

So, I'm wondering if anyone knows whether there are any studies using Avistan for POHS and if so, who is doing them? Otherwise, does anyone know why POHS might not be treatable with Avistan?

Thanks... I'm not expecting a response, but thought it was worth asking.


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