Discussions By Condition: I cannot get a diagnosis.

Recreational drug overdose left me disabled 10 years with very odd symptoms

Posted In: I cannot get a diagnosis. 11 Replies
  • Posted By: Unlucky
  • December 13, 2009
  • 05:14 PM

I overdosed on a coctail of ecstacy and amphetamines 10 years ago which resulted in immediate brain damage leaving me with a Neurological illness known as Autonomic Dysfunction and with a series of very bizarre symptoms unlike anything ever heard of in medical literature, no specialist has been able to diagnose or cure me as yet.....

MY ODD SYMPTOMS ARE :
-------------------------

- Overheating every day with high tempearures and fevers for the past 10 years since my overdose. Unable to go out into the sun or warm environments. Spend a lot of time indoors in front of the cooling system, even in winter!

- Developed an unusual allergic / severe adverse reaction to all drugs that effect the autonomic system such as painkillers, sedatives, alcohol, stimulants, anelgesics and opiates. This adverse reaction began immedeately following the overdose 10 years ago. As a result I am now unable to have surgery due to the risks with anesthesia or take even the smallest amount of opiate painkillers to manage chronic pain. Taking a small amoung of any psychoactive substance causes hyperthermia, respiratory depression, muscles spasms, headaches, feeling horrible and unwell, agitation, confusion, severe fluctuations in blood pressure irregular heart rates sometimes very high and other times very low.

- Experiencing bizarre problems with sexual activity where feeling aroused results in muscle spasms throughout the whole body and an actual orgasm causes hyperthermia with temperatures above 38.6 c. Attended the ER several times in the past directly after an orgasm resulted in high fevers and nausea, this odd response to sex also began immedeatly after the overdose 10 years ago.

-Experiencing the more common symptoms of Autonomic Dysfunction everyday such as fainting and rapid heart rates from postural changes, fatigue, diziness, muscular pain, digestive problems, heat intolerance, inability to sweat, dry eyes, poor memory etc. also began directly after the overdose.

Prior to my overdose I was very haelthy and had no medical problems and none of the symptoms descibed but one single overdose changed my life overnight and now I'm disabled and I feel so damaged and frustrated beyond repair, it has been 10 long years and I cant find anyone who can fix me or diagnose me, I am so angry and upset with doctors, I have contacted world leading experts and Professors in Pharamacology and Toxicology specialising in adverse drug effects, Thermoregulation, Autonomic specialists and they have failed to reply to my emails or help adequetly. Shame on them!!!! I hate them all!!! :mad:

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11 Replies:

  • Your thermal issues make me think of mitochondrial disease... Heat in warm blooded mammals is generated in the mitochondria as they generate ATP. I have read that when ATP synthesis is hampered, mitochondria can produce excess heat trying to generate enough ATP. (Aspirin inhibits ATP production and people who take daily aspirin are advised to take it in the morning rather than at night, as the body tries to cool down a bit at night and taking your aspirin in the evening prevents this cool down) Google around on Mitochondrial Disease and see if anything looks like what you have. Acetyl-L-carnitine, and Lecithin are two supplements I take for mitochondrial support. Mitochondrial membranes are made of phospholipids, and Lecithin (a phospholipid) can repair damaged mitochondrial membranes. You need to take several Lecithin gelcaps per day, and results will not show up for a few (3?) months. Good Luck and GodSpeed
    synesthesia 87 Replies
    • December 14, 2009
    • 02:32 AM
    • 0
    Flag this Response
  • Hi, Thanks for the response, I had never heard of mitochondrial disease before, I have looked it up now and I'm not sure but I dont think its what I have, a lot of the other symptoms don't match, but I will still mention it to my neurologist and see hat he thinks, thanks. Nice one on suggesting the aspirin, shows you were thinking along the same line as us when about 8 years ago me an my neurologist were trying out various meds to reduce the fevers and aspirin was one of them but unfortunately it didnt seem to help at the time, I even tried a medication that women use for hot flashes as an experiment, even though I am a guy :D, that didnt help either though.
    Unlucky 15 Replies
    • December 14, 2009
    • 04:48 PM
    • 0
    Flag this Response
  • Your thermal issues make me think of mitochondrial disease... Heat in warm blooded mammals is generated in the mitochondria as they generate ATP. I have read that when ATP synthesis is hampered, mitochondria can produce excess heat trying to generate enough ATP. (Aspirin inhibits ATP production and people who take daily aspirin are advised to take it in the morning rather than at night, as the body tries to cool down a bit at night and taking your aspirin in the evening prevents this cool down) Google around on Mitochondrial Disease and see if anything looks like what you have. Acetyl-L-carnitine, and Lecithin are two supplements I take for mitochondrial support. Mitochondrial membranes are made of phospholipids, and Lecithin (a phospholipid) can repair damaged mitochondrial membranes. You need to take several Lecithin gelcaps per day, and results will not show up for a few (3?) months. Good Luck and GodSpeed Hi I was wondering if you were still on here as I wouls really like to talk to you. I think I have something similar going on.. Pleas respond!!!
    ecko23 51 Replies Flag this Response
  • Yes sounds like an autonomic nervous system dysfunction going on. The ANS maintains homeostasis in the body eg pupil size, body temp. etc etc and if one damages this, one is often screwed. The ANS is regulated by the hypothalamus and the medulla oblongata, parts of the brain so i guess also damage to those parts probably can cause ANS dysfunction too. i've found myself that specialists do not know how to fix ANS dysregulation issues (ive asked various specialists ive seen). Like you I have a BP dysregulation as one of the symptoms with it going low but also very high. No one knows how to fix it, i cant be treated for high BP even thou mine gets severely high.. as mine also gets very low. I dont think one can blame doctors for not helping you in this area.. as this is unfortunately an area in which much just isnt known about. i dont even know what kind of specialist who specializes in ANS dysregulation (is there even a certain type of specialist for this??) so havent been able to see anyone who knows about this issue
    taniaaust1 2,267 Replies Flag this Response
  • Hi Guys, thank you for the responses, and yes ecko I'm still here if you want to talk to me about the similarities with your symptoms. I created this topic about 7 months ago and unfortunately nothing has changed since, I feel so helpless everyday, I know I shouldn't be angry at the doctors about this, but I believe science has advanced enough to help me and further investigate the symptoms I suffer with everyday and diagnose the specifics of the brain damage I sustained when I overdosed however because my situation is so uncommon that no one seems to be willing to look further into it and for that neglect I am upset.
    Unlucky 15 Replies Flag this Response
  • Hi Guys, thank you for the responses, and yes ecko I'm still here if you want to talk to me about the similarities with your symptoms. I created this topic about 7 months ago and unfortunately nothing has changed since, I feel so helpless everyday, I know I shouldn't be angry at the doctors about this, but I believe science has advanced enough to help me and further investigate the symptoms I suffer with everyday and diagnose the specifics of the brain damage I sustained when I overdosed however because my situation is so uncommon that no one seems to be willing to look further into it and for that neglect I am upset. I find youre sensitivities to certain drugs interesting. As I to can not take certain drugs or I go into some kind of attack. It is scary as ***l. I cant take any street drugs pain killers even cetain vitimans like fish oil. Cant even take prilosec for heart burn. But I can take ranitidine for heart burn. I mean wtf is that?? This all happen to me about ten years ago also after a night of doing cocaine. But do you have yahoo messanger or something like that so we can chat??
    ecko23 51 Replies Flag this Response
  • Hi Ecko, I ocassionally use msn messnger so maybe we can speak on there, I tried to send you a private message of my username so you can add it however I was unable acess the function on this site, maybe because I dont have sufficient privalages to private messege people on here due to my low post count? perhaps you have any suggestions to exchange details so we can add each other on chat ?
    Unlucky 15 Replies Flag this Response
  • Hi Ecko, I ocassionally use msn messnger so maybe we can speak on there, I tried to send you a private message of my username so you can add it however I was unable acess the function on this site, maybe because I dont have sufficient privalages to private messege people on here due to my low post count? perhaps you have any suggestions to exchange details so we can add each other on chat ? msn messanger does not work on my pc for some reason. Do you think that you can make a yahoo account so we can chat on there?? Sorry for the trouble I have been trying to get that to work on my pc for a couple months now.
    ecko23 51 Replies Flag this Response
  • Hey Unlucky how you been?? I havent heard back from you and I am still really wanting to chat with you.. Hope everything is going good and really hope to hear back from you....
    ecko23 51 Replies
    • September 20, 2010
    • 04:42 PM
    • 0
    Flag this Response
  • Hey unlucky I still very much would like to talk to you. Does anything happen to you when you are around strong smelling cleaners? Does youre head ever feel funny? I dont know if you smoke cigs but did anyting happen wen you tried tose??
    ecko23 51 Replies Flag this Response
  • hi everyone i'm new here.... welcome to all.
    DorothyHick 6 Replies Flag this Response
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