(Further history at the end.) I've been suffering from IBS for at least 10 years now, but in the past month, I've had several troubling episodes with new--or at least significantly worse--symptoms. During the worst episode, I had pain and tenderness on my right side (URQ, right under the ribs almost on my side, not abdomen, and a large area underneath that at the height of my belly button down to the LRQ) that got progressively worse and cramps more toward the center of my abdomen. I also had noticeable nausea. I lay down for a while and napped, but I eventually had to get up to use the facilities because the pain was so bad and going was imminent. The diarrhea was worse than usual and took 10-15 minutes to finish; stools were not fatty (did not float). Then I took some Aleve for the pain, lay down, and slept for 12 hours. After being awake for 4 hours, I soon became fatigued and slept again, this time for 16 hours.
The most recent episode wasn't quite as bad as that, but the diarrhea was again worse than, and took longer than, usual. Pain again flared up all over my right side, and the nausea was worse. I'm still suffering from the pain/tenderness and nausea, so I can't tell you how long it lasted.
I've had chronic pain, mostly in the URQ but often additionally extending down to the LRQ, in the same places, for about half the time for a few years now, but it's usually an annoyance and goes away with Ibuprofen or Aleve. Before that, I had chronic pain on my LRQ that confused my then-doctor. According to her and a later doctor, at least at the time (up to my last test about a year ago), my liver function tests were normal. I visited an urgent care clinic a few weeks ago due to severe, middle-abdomen cramping that persisted for 4-5 days, and my CBC came back normal. (That doctor recommended I see a GI specialist to root out the real cause of my IBS, though I had never experienced this symptom before.)
Additional history: I've suffered from moderate depression (possibly major at times) for about 15 years, and last December, I started having generalized anxiety that was not tolerable without treatment. I've taken Lexapro, daily, for 8 years; I've taken Lunesta most nights for 4 years; I've taken Xanax (1/4 mg) daily since December. I haven't had a regular sleep schedule in 12 years; I regularly sleep for 12-16 hours at a time and have great difficulty going to sleep. I regularly used Ibuprofen but now use Aleve for my abdominal pain; separately (and not at the same time), I've used Excedrin for regular migraines. I've been taking the Align probiotic daily for over a year, which has decreased the frequency of my diarrhea significantly. I gave up liquid or soft dairy products (but not hard cheese) about a year ago as milk was contributing to my GI problems. I also suffer from mild-to-moderate sleep apnea, for which I sleep with an oral appliance.
I'm currently unemployed as my depression and anxiety symptoms have got progressively worse; I'm awaiting treatment at an indigent care program for my mental health issues, but there is no such system for general health in my area (Dallas area; Collin County).
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