Discussions By Condition: Rare Disases

Gene Carriers

Posted In: Rare Disases 2 Replies
  • Posted By: Anonymous
  • August 30, 2006
  • 00:20 PM

I would like to find out if one parent has the disease would the children test positive for the gene, but not necessarily have the disease? Any information would be helpful.

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2 Replies:

  • If one parent has a disease and the other parent is not a carrier or does not have it then there is a 50/50 chance your children will get it.Say that the father had it and mother didn't.If he has any boys, they won't have it, but if he has girls they will be carriers of it.
    Anonymous 42,789 Replies Flag this Response
  • It depends on how the disease is genetically carried. For instance with Fabry's disease it is carried solely on the x chromosone. Men are XY and women are XX. So if the father has it and has a boy he can only donate a good y and the male child would not have it. If it was a girl he can only donate a bad x and she is an automatic carrier of the disease. If the mother had Fabry's disease she is XX. So it would depend on whether the bad x or the good x got donated whether the child would have the disease or be a carrier. Each parent donates one chromosone. So Father xy donates a y for a boy or an x for a girl. A mother is xx and can only donate an x. Genetics can get confusing but I hope this helps.
    Anonymous 42,789 Replies Flag this Response
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