Discussions By Condition: Muscle conditions

What could it be? Lactic acid unusually high for an unusually long period of time.

Posted In: Muscle conditions 1 Replies
  • Posted By: Komodia
  • August 1, 2010
  • 10:42 AM

My father has had problems with his muscles ever since he was young, but it has, apparently, worsened with age, despit his muscular built. What could it be?

His muscles seem to have trouble getting rid of lactic acid, which was measured in an exam and was extremely (and unusually) high after going up and down the stairs, for a prolonged period of time. This produces cramps and makes the muscles feel stiff, even to touch. When he was younger this would happen whenever he excercised, with a much higher intensity than normal. Now that he's on his early 50's, he can get it from repetitive movement, for example, opening bottles or even zapping. His muscles become stiff and go sloooowly back to normal.

He also has hypertension.


Any ideas of what illnesses could be causing this? None of his sisters or daughters have had this. He has no male direct relatives besides his deceased father, who, apparently (we never asked directly), didnt suffer from this, but had several back problems and even went through surgeries for it. His mother has hypertension, and it runs in the family.

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1 Replies:

  • It might be beneficial to have a muscle biopsy preformed to look for Ragged Red Fiber (RRF.) RRF is an accumulation of dysfunctional mitochondria, and is often caused by mitochondrial diseases. The mitochondria is the powerhouse of the cell; it's here that energy is produced. Mitochondria also have dna, and the dna codes for a variety of things, including the proliferation of the mitochondria. A rare number of individuals have defects in their mitochondrial genes, leading to cell dysfunction. MERRF, MELAS, and CPEO (along with the more severe presentation of Kearn Sayre) would be the most probably avenues. Ocular symptoms are common; does he have ptosis (droopy eyelids) or ophthalmoparesis (lazy eye)?
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