Discussions By Condition: Muscle conditions

25 yr old female: knee swelling, inflammation, Thyroid disease, HLAB 27 positive

Posted In: Muscle conditions 3 Replies
  • Posted By: justineb
  • October 4, 2008
  • 04:17 AM

I am almost at my wit's end with my health problems.

Background:


25 year old white female.
Tested negative for: lupus, RA, lyme disease, Chlamydia
Tested positive for: HLAB 27
Occasionally my knees fill up with fluid, but once it was drained / aspirated and injected with cortisone, the knees were fine.


Episodes / Health Problems:


At age 15, I had woke up with stiff hands and feet - couldn't stand up or touch anything without it being painful and extremely uncomfortable. No changes in my diet or routine previous to that episode day. The only odd sign was tingling in my fingertips the night before. Blood tests came back negative. Treated with 7- day prednisone pack, no further problems.
At 16, I was diagnosed with multi-nodular goiter / thyroid condition. I had a biopsy on done and was benign. Blood tests came back and I was neither hypo- nor hyperthyroid.
At 19, I woke up one morning with a stiff shoulder. No trauma / injury related. Which ended up progressing into a limited range of motion shoulder and I couldn't move it at all. I had a shoulder arthroscopy at 21, showed high inflammation, bone chips and torn ligaments.
At 21, another odd episode occurred: the night before, tingling fingertips again and the next morning, I woke up with a swollen / puffy face, cheeks and lips. Hives on my back. Hardly could open my eyes. Doctor's didn't believe it was allergy related. Blood test showed HLAB 27 positive. Treated with 7-day prednisone pack and symptoms gone.

At 22, one knee (right side) filled up with fluid. Again, no trauma / injury related. Knee drained and shot with cortisone. The synovial fluid showed no bacteria or infection, mild inflammation.

At 23, both knees (left and right side) filled up with fluid. Again, no trauma / injury related. Knees drained and shot with cortisone. The synovial fluid showed no bacteria or infection, mild inflammation.
At 25, both knees (left and right side) filled up with fluid. Again, no trauma / injury related. Knees drained and shot with cortisone. The synovial fluid showed no bacteria or infection, mild inflammation. However, this time...the knee draining only lasted about 2.5 weeks before returning.

At 25, knees drained 4 weeks after last draining and it returned the next day. No injections given. Muscles around the knee are sore and stiff. Started sulfazine at 500 mg three times a day and prednisone at 5mg one time a day.

At 25, a month after last draining, knees still full of fluid and I feel like I'm suffering from atrophy from not being able to exercise the knee.


Which brings me to today, I'm going in for an MRI on both of my knees next week. I have been told I have reactive arthritis...but doesn't that go away after sometime? I am not sure why my knees are in such bad shape and why they keep filling up with fluid.

Does anyone have a similar problem? Suggestions?













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3 Replies:

  • Hi I have the same problem had surgery Jan.7 2009 on my right knee for missing cartlige and torn menecis but 3 weeks later and I have extreme fluid in my knee.My doctor drained it 3 days ago and put cortisone in it but the pain and fluid are back also the fluid had blood in it. Don't know what's causing it and really frustrated.
    Anonymous 42789 Replies
    • January 30, 2009
    • 00:54 AM
    • 0
    Flag this Response
  • justineb,Interesting. I have a similar situation. I'm 33 years old. I never had any knee pain or swelling until 3 years ago. Felt a pop near my left knee one day kneeling on the floor. Ever since I've had major fluid first in the left knee and a few months later in both knees. I've been to rheumatologists, had both knees drained several times (which helped significantly), tested negative for lupus, RA, lyme disease, and even negative for HLBA27. I'm on sulfasalaxine, hydroxichloriquine and prednisone 7mg/day and swelling is tolerable but still have quite a lot of fluid on top of both knees. Flare ups come and go weekly. I've never had any major injuries to my legs - just some abnormal blood clotting after this whole experience started.The last 4 years I've had a good amount of pain in my left shoulder/clavicle area front and back near my spine pretty much every day. That's it. No other pain or swelling anywhere else. I would be interested to hear more about your treatments and if you've had any luck figuring out your inflammation. It's quite a frustrating, mysterious problem and I've yet to find anyone with such a similar situation.-brad-I am almost at my wit's end with my health problems. Background: 25 year old white female.Tested negative for: lupus, RA, lyme disease, ChlamydiaTested positive for: HLAB 27Occasionally my knees fill up with fluid, but once it was drained / aspirated and injected with cortisone, the knees were fine. Episodes / Health Problems:At age 15, I had woke up with stiff hands and feet - couldn't stand up or touch anything without it being painful and extremely uncomfortable. No changes in my diet or routine previous to that episode day. The only odd sign was tingling in my fingertips the night before. Blood tests came back negative. Treated with 7- day prednisone pack, no further problems.At 16, I was diagnosed with multi-nodular goiter / thyroid condition. I had a biopsy on done and was benign. Blood tests came back and I was neither hypo- nor hyperthyroid.At 19, I woke up one morning with a stiff shoulder. No trauma / injury related. Which ended up progressing into a limited range of motion shoulder and I couldn't move it at all. I had a shoulder arthroscopy at 21, showed high inflammation, bone chips and torn ligaments. At 21, another odd episode occurred: the night before, tingling fingertips again and the next morning, I woke up with a swollen / puffy face, cheeks and lips. Hives on my back. Hardly could open my eyes. Doctor's didn't believe it was allergy related. Blood test showed HLAB 27 positive. Treated with 7-day prednisone pack and symptoms gone. At 22, one knee (right side) filled up with fluid. Again, no trauma / injury related. Knee drained and shot with cortisone. The synovial fluid showed no bacteria or infection, mild inflammation.At 23, both knees (left and right side) filled up with fluid. Again, no trauma / injury related. Knees drained and shot with cortisone. The synovial fluid showed no bacteria or infection, mild inflammation.At 25, both knees (left and right side) filled up with fluid. Again, no trauma / injury related. Knees drained and shot with cortisone. The synovial fluid showed no bacteria or infection, mild inflammation. However, this time...the knee draining only lasted about 2.5 weeks before returning. At 25, knees drained 4 weeks after last draining and it returned the next day. No injections given. Muscles around the knee are sore and stiff. Started sulfazine at 500 mg three times a day and prednisone at 5mg one time a day.At 25, a month after last draining, knees still full of fluid and I feel like I'm suffering from atrophy from not being able to exercise the knee.Which brings me to today, I'm going in for an MRI on both of my knees next week. I have been told I have reactive arthritis...but doesn't that go away after sometime? I am not sure why my knees are in such bad shape and why they keep filling up with fluid. Does anyone have a similar problem? Suggestions?
    chumsicle 1 Replies
    • August 30, 2010
    • 08:19 PM
    • 0
    Flag this Response
  • Well im a age 14 athlete . I have had the EXACT same problem . Ive been going to the prthopiedic ive visited the rheumatoligist and am just starting psyichal therapy . I have major discomfort . It started on the left knee and is totally problem free on the left while very painfull and discomfort on the left . Im only 14 and pretty good at sports good enough for college . I have them drained mostly everytime i go . This is horrible and the doctors are stooped .
    Anonymous 42789 Replies Flag this Response
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