Caffeine induced myoglobine syndrome, a rhabdomyolysis based form of
Caffeine is known to potentiate adrenaline secretion and adrenaline is
known to affect calcium and sodium balance of resting skeletal muscle
cells. When extra- and intracellular sodium levels alter, water is moved
in and out of cells in order to maintain intra-extra-cellurar water
sodium balance. While doing this, water may enter the cell in such
measures, that the cell layer breaks down.
Adrenaline levels are affected by various other reasons as well, but
the chronic effect emerging from caffeine dependence, may be the most
important factor in persons with a caffeine sensitive HPA-axis and/or
poor caffeine biotransformation, due to genetic or other factor related
to the function of cytochrome P450 in liver.
I put for you, that this mechanism causes stress to cells in such
measure, that they break down and part of myoglobine is leaked out to
bloodstream, while most remain in muscle tissue for an unknown reason,
causing neuropathy in areas, where accumulation is heavy, usually in
Free myoglobine in blood causes slowly growing toxic stress to brain
cells, which is amplified by the effects of caffeine to HPA-axis. Levels
ov various neurotransmitters and their receptor densities are altered
slowly in different parts of brains, causing symptoms, that may stay
hidden for years under the stimulating effects of caffeine, before they
can be diagnosed.
This kind of poisoning (caffeinism) manifests itself in various symptoms
ranging from depression to schizophrenia, they may include peripheral
neuropathy from muscle stiffness all the way up to multiple sclerosis,
according to genetic variations.
Myoglobine syndrome kan be tested very easy with myoglobinuria test,
myoglobine excretion accumulates as the water capacity of the body is
cleaned from methylxanthines. This takes usually about a week. Excretion
of myoglobin may be accumulated with a suitable chelator like DMSA os
garlic, or any other sulphur based treatment, but care should be taken,
that too much myoglobin is not released, as it may cause various serious
acute symptoms, kidney damages, psychosis and even a sudden death.
Chelation and blood filtration may be necessary in worst cases.
The mechanism in short.
The mechanism of rhabdomyelosis is not understood, neither is caffeines way to induce very slowly advancing muscle cell destruction in skeletal muscles.
The mechanism is simple, caffeine raises adrenaline level, adrenaline accelerates the sodium pumps of resting skeletal muscle cells pushing sodium in the cells. Sodium binds water to itself, the cell swells, until it breaks and releases myoglobine, which contains heme, which is made of iron heart and porphyrines, the colour agent of heme, which is very powerful neurotoxin.
This is the mechanism of chronic caffeine poisoning, caffeinism.
Now you know the mechanism, and can prove caffeinism with lab tests.
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