Thank-you everyone for descriptions of transient swollen lips and itchy erythrothema to other areas of the body. I would like to add my own experience. I am 50 years old and these symptoms began approximately 5 years ago.
Relevant history. Early childhood excema, not severe. Late teens to early 20s, hayfever which discontinued. 30's, short bout of asthma, possibly due to stress.
I experience swollen lips, in various combinations of upper left/right quadrant, lower left/right quadrant, less frequent nose swelling, possibly associated with wearing glasses and pressure on the nose, and less frequently puffiness around the eyes. This is usually associated with red welts to other parts of the body, arms, legs, soles of feet, practically anywhere.
I have noticed it usually happens when I have been under stress, working hard, long hours, or something emotional has happened. So I try to avoid these situations, but I do get caught out.
I have not had much success with pharmacological treatment. I have tried the antihistamine promethazine at the onset of symptoms and later. It might help a little, but not very much. I suspect that histamine is not the only mediator of these events, but it might contribute together with other inflammatory mediators. I have also tried corticosteriods, but again without a lot of success.
I have been to an immunologist who scoffed at the idea that stress was the cause. The immunologist also said the symptoms were mediated by histamine and indicated more antihistamines. I am most certain the immunologist has not given the full explanation. It probably means the immunologist did not understand cause and effect in this case.
Thanks for help and for this forum