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Nubain - a near fatal experience

Posted In: Medical Stories 21 Replies
  • Posted By: keishainu
  • June 25, 2009
  • 06:39 AM

On Friday, June 19, 2009, I visited the local Urgent Care Center for treatment of a migraine headache. I was given an injection of Nubain. Within 5 minutes I began reacting. By 20 minutes, 911 had been called and 4 EMT's arrived at my home to find me in the bedroom screaming and convulsing. It took 2 EMT's holding me down as a 3rd. placed an IV line. I was taken to the ER here in Sedona, AZ where for the next 7 hours I screamed and convulsed. The meds given were "enough to drop an elephant" yet nothing could antidote that injection. The ER Doc had never seen this radical of a reaction. It is now Wednesday and I am still reacting to that injection. Tomorrow I go to an NMD who is going to try and counter the reaction. Has anyone out there experienced "going crazy" when given that drug, or know what to do to antidote it. All possible information sites were checked by the ER and nowhere did the Company, Endo Pharm, have instructions to antidote this severe of a reaction. All suggestions will be appreciated and does the company Endo Pharm have any responsibility for not having a posted antidote. Thanks Much

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  • I have been taking methadone for pain for around 8 years. My doctor was aware I was taking this medicine since he prescribed it for me every month. He gave me a shot a Nubain. These two medications are not good together and the reaction was very severe.The Nubain cause me to go into a rapid withdrawal from the methadone. I had severe withdrawal symptoms. (more severe than I have heard some heroin addicts have described). The reason I take methadone is for pain. I broke my back as a child and it took 20 years for a doctor to find out that I really had a back problem. This caused major damage in my nerves and muscles. The cramps from the withdrawal were so severe they would bend me in half sideways. I can not bend sideways. I also emptied everything in my body so many times I just wanted to die. The doctor would not even call 911. I was in his office for hours in terrible pain and was in such bad shape I honestly thought I was dying. This is no where near everything that happened to me that day but hopefully it is enough that the information will help you.I know this is not the same reaction or same reason for your reaction to the medicine but I felt I should mention it in case you are on a medicine for pain that could have caused a reaction similar to this.
    TriciaS 3 Replies Flag this Response
  • BINGO....I, too have been on methadone for pain a little over ten years for chronic pain...it is the only pain med that allows me to function without feeling like my head is up my *** and in a fog. I can think, respond and move without the haze of other drugs. I sure hope you took that nut case Doc for a ride in the woods for refusing to call 911.....did you wonder whose's behind he was covering? How long ago did this happen. I found out this same info by going to ...allnurses.com website..very good info there. By the way this info is nowhere to be found in any of the ENDO Pharm materials. Keep in touch...GinnyB
    keishainu 25 Replies Flag this Response
  • Please consider acupuncture to help with your detox as well as with your pain. NADA auricular acupuncture detox may really help...acupuncture is very effective for chronic pain conditions. Methadone is a very strong med. Best wishesDOM
    acuann 3080 Replies Flag this Response
  • BINGO....I, too have been on methadone for pain a little over ten years for chronic pain...it is the only pain med that allows me to function without feeling like my head is up my *** and in a fog. I can think, respond and move without the haze of other drugs. I sure hope you took that nut case Doc for a ride in the woods for refusing to call 911.....did you wonder whose's behind he was covering? How long ago did this happen. I found out this same info by going to ...allnurses.com website..very good info there. By the way this info is nowhere to be found in any of the ENDO Pharm materials. Keep in touch...GinnyB It has been a while since this happened to me. I think it was around 1-1/2 years ago. I have never seen the doctor again that did this to me and it was very hard not to talk to a lawyer about it. I have been thankful for the relief methadone has given me from my pain. I have taken methadone for about 8 years now. I was actually able to work for several extra years because the methadone helped me that much. I have tried several of the other pain narcotics but I feel most comfortable with the methadone. It does not give me any of the "high" feeling some of the others did. The only one that helped me more was the fentanyl patches (I was allergic to the adhesive). From what I understand about methadone it coats all the pain receptors in the brain. When certain other pain meds are given it knocks the methadone off those receptors and causes a several rapid detox reaction until the methadone is replaced on those receptors. I am not positive this is accurate but it was the only thing I was able to find that made any sense out of what happened to me. This had to be one of the most horrible experiences of my life. I was in pain for over a week due to the muscle cramps and evacuation of all my body fluids for so many hours.The doctor kept me in his office for over 6 hours until I was able to walk out on my own and drive myself home. If I had gone to the ER they could have given me IV methadone and it would have only been an hour or maybe two of the severe withdrawal.I have been so afraid of any injections since this happened to me. When taking methadone it is important to find out anything you are being injected with and for the medical professionals to know you are on methadone. I have safely been given morphine and a medication that begins with a D after several surgeries this last year where I had to have injectable pain medication.I know who he was covering when he did not get me to the hospital!!! He has been in trouble for different things for years. I was so hurt that he would let me suffer like that and just send nurses to check on me every hour or so. I thought doctors were suppose to try to stop suffering and pain not just watch it after they have caused it. It seems like he would have called the ambulance and insisted I go to the ER. I found out I could have died from this because of all my medical problems.I recomend you get a medical alert bracelet that lists methadone on it and was tole by one doctor that I should list nubain and stadol as allergies while on methadone.Best wishes!Tricia
    TriciaS 3 Replies Flag this Response
  • Have tried accupuncture - it helped with adrenal issues but did nothing for the chronic pain. I have the best results with chelation IV therapy, Myers regular and anti-viral cocktails and vit B & C IV drips - I do the Vit B & C drips weekly and an anti-viral once a month. I also do Fredd's B12 program. Have been on it one month with very positive results...am down to 1 methadone a day and then only when I can no longer stand it. This last thing was a severe chemical reaction to a drug never used before...or again.....what really angered me is...nowhere in any Endo Pharm information does it address the methadone issue....Oh, well, if the drug companies don't get you.....O"Bam Bam's new "Health Care"... will....as one of the Senators said.....Sr.'s are going to have to accept the pain of aging...just suck it up! Sure wish those idiots would be stuck with the same Health Care Plan that we are....but the Golden Girls and Boys are exempt......only exemption should be our Veterans...they should get the BEST....and they don't.....go figure!!!!.....We, the Employers get the bologna while our Employees (the Government) dine on Filet......AAARGH. Reveloution anyone?
    keishainu 25 Replies Flag this Response
  • Have tried accupuncture - it helped with adrenal issues but did nothing for the chronic pain. I have the best results with chelation IV therapy, Myers regular and anti-viral cocktails and vit B & C IV drips - I do the Vit B & C drips weekly and an anti-viral once a month. I also do Fredd's B12 program. Have been on it one month with very positive results...am down to 1 methadone a day and then only when I can no longer stand it. This last thing was a severe chemical reaction to a drug never used before...or again.....what really angered me is...nowhere in any Endo Pharm information does it address the methadone issue....Oh, well, if the drug companies don't get you.....O"Bam Bam's new "Health Care"... will....as one of the Senators said.....Sr.'s are going to have to accept the pain of aging...just suck it up! Sure wish those idiots would be stuck with the same Health Care Plan that we are....but the Golden Girls and Boys are exempt......only exemption should be our Veterans...they should get the BEST....and they don't.....go figure!!!!.....We, the Employers get the bologna while our Employees (the Government) dine on Filet......AAARGH. Reveloution anyone? Hi GinnyB, Nubain is a opioid agonist/antagonist like Talwin, Stadol and Buprenorphine. That means that it will put somebody accomodated to opioids into instant withdrawal. Also, these agonist/antagonist drugs tend to have a more peculiar set of side effects including a greater propensity to produce pshyuchological and hallucinatory side effects. This drug should not be used by those accomodated to opioids. You may have a case against the urgent care for using a drug cautioned against use in such an instance. http://www.deadiversion.usdoj.gov/drugs_concern/nalbuphine.htm Nalbuphine is ten times more potent than pentazocine as an antagonist and will precipitate withdrawal in an opiate-tolerant individual. My own experience at mixing Stadol and morphine is that it gets rid of incredibly terrible headaches very effectively and quickly. The trick is to take the morphine 20 minutes before the Stadol. However Stadol does carry the same warning as Nubain. In the Phase III study of Stadol I was in the protocol allowed mixed use of Stadol and codeine, quite sucessfully I might add. http://www.rxlist.com/nubain-drug.htmPatients Dependent on OpioidsPatients who have been taking opioids chronically may experience withdrawal symptoms upon the administration of NUBAIN. If unduly troublesome, opioid withdrawal symptoms can be controlled by the slow intravenous administration of small increments of morphine, until relief occurs. If the previous analgesic was morphine, meperidine, codeine, or other opioid with similar duration of activity, one-fourth of the anticipated dose of NUBAIN can be administered initially and the patient observed for signs of withdrawal, i.e., abdominal cramps, nausea and vomiting, lacrimation, rhinorrhea, anxiety, restlessness, elevation of temperature or piloerection. If untoward symptoms do not occur, progressively larger doses may be tried at appropriate intervals until the desired level of analgesia is obtained with NUBAIN.
    Freddd 3576 Replies Flag this Response
  • Have tried accupuncture - it helped with adrenal issues but did nothing for the chronic pain. I have the best results with chelation IV therapy, Myers regular and anti-viral cocktails and vit B & C IV drips - I do the Vit B & C drips weekly and an anti-viral once a month. I also do Fredd's B12 program. Have been on it one month with very positive results...am down to 1 methadone a day and then only when I can no longer stand it. This last thing was a severe chemical reaction to a drug never used before...or again.....what really angered me is...nowhere in any Endo Pharm information does it address the methadone issue....Oh, well, if the drug companies don't get you.....O"Bam Bam's new "Health Care"... will....as one of the Senators said.....Sr.'s are going to have to accept the pain of aging...just suck it up! Sure wish those idiots would be stuck with the same Health Care Plan that we are....but the Golden Girls and Boys are exempt......only exemption should be our Veterans...they should get the BEST....and they don't.....go figure!!!!.....We, the Employers get the bologna while our Employees (the Government) dine on Filet......AAARGH. Reveloution anyone? Hi Ginny, So you are doing well on the b12 protocol? That's good to hear.
    Freddd 3576 Replies Flag this Response
  • am down to 1 methadone a day and then only when I can no longer stand it. I was not sure if you were told by your medical people just how methadone works in the body. It is important that methadone be taken every day and the amount should not be varied unless changed by the doctor. Methadone has a long half life so it stays in your body longer than most medicines that are not considered long acting. If you will take the methadone daily at bedtime or split your pill and take half in AM and half in PM you may be pleasantly surprised at the difference in how much better you are doing. By taking the meds more reguarly, this keeps the level of methadone consistent in the blood. Most medicine that is taken at home is better at keeping you out of pain than stopping your pain once it has gotten going. This was one of my hardest lessons. I hated taking ANY meds and I would wait and wait. By the time I took the meds I was in terrible shape and sometimes would end up in the hospital. I have not had to go to the ER for pain control in many years. The only change is learning how to take my meds correctly and getting the dosage correct for me.The most important thing is to never take extra medicine unless prescribed. I have seen so many overdoses with methadone because the patient takes it like they would hydrocodone and they overdose. It can take up to 3 days for the medicine to start leaving the system so when you take a pill you are taking it on top of the last 2 days pills.I really hope I am making sense. It is a little hard to describe half life of medicine with out getting deep into chemistry. If someone knows how to describe it better please add your input. Good LuckTriciaS
    TriciaS 3 Replies Flag this Response
  • Thanks, Tricia..didn't realize it had that long of a half life. will try the half in am and pm. I, too, hate taking meds of any kind...seems all Docs want to do is give you a pill. Went to a more natural leaning Doc and ended up with a sackfull of "vitamins and other supplements"..to the tune of $175.00 per month....never went back....will keep you posted...GinnyB
    keishainu 25 Replies Flag this Response
  • On Friday, June 19, 2009, I visited the local Urgent Care Center for treatment of a migraine headache. I was given an injection of Nubain. Within 5 minutes I began reacting. By 20 minutes, 911 had been called and 4 EMT's arrived at my home to find me in the bedroom screaming and convulsing. It took 2 EMT's holding me down as a 3rd. placed an IV line. I was taken to the ER here in Sedona, AZ where for the next 7 hours I screamed and convulsed. The meds given were "enough to drop an elephant" yet nothing could antidote that injection. The ER Doc had never seen this radical of a reaction. It is now Wednesday and I am still reacting to that injection. Tomorrow I go to an NMD who is going to try and counter the reaction. Has anyone out there experienced "going crazy" when given that drug, or know what to do to antidote it. All possible information sites were checked by the ER and nowhere did the Company, Endo Pharm, have instructions to antidote this severe of a reaction. All suggestions will be appreciated and does the company Endo Pharm have any responsibility for not having a posted antidote. Thanks MuchHi friend, How are you doing with migraine headaches now? If you come to Phoenix area get in touch with me PArjuna85210@yahoo.com. I can relieve your migraine in ten minutes by manipulating your neck muscles. I took my time to answer you. You take a few minutes of your time to reply.(FREE Service)Knowledge is power and ignorance is expensive.Good luck my friend...
    PArjuna 43 Replies Flag this Response
  • Hi Keishainu, I would like to clarify a few things about methadone. It is very long serum halflife, or at least it's metabolites are, about 25-50 hours. It takes 1-2 days to reduce by 50%. It takes about 10 halflifes to be mostly gone, that's 10-20 days. When people are titrating they tend to get in trouble on the 3rd to 5th day becauye of that. However, your reaction described doesn't sound like an abrupt withdrawal per se. I would like to know what other meds you may be accomodated to or what other items you may have been taking. Sometimes combinations can have weird effects. You can write me to keep it more private if you like. Include any sleep aids, antihistamines, stimulants etc. I'm a collector of unusual reactions, making connections sometimes 20-30 years apart. I heard of things like this but I need more details. Can you describe the subjective experience in a lot more detail? What where you thinking? Did you have thoughts of dying? Were the yells caused by forceful contraction of the lungs? Were the muscle contrations whole body things? Do you meditate or do tantric practice or kundalini? Was there a "sound" like a high voltage hum or anything? What medications were given in the ER? Good luck.
    Freddd 3576 Replies Flag this Response
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  • Dear Parjuina, Thank you for your offer. I do not travel too far from home especially down to the black cloud we highlanders call Phoenix. I do practice meditation, Quiong and Tia Chi and have had physical therapy called Zero Balancing. Thanks again for your offer.
    keishainu 25 Replies Flag this Response
  • Hey Fredd, Have been under the weather since the trip to the ER..plus the weather fronts have been coming and going like crazy. Will e-mail you in detail at a later date. The IV's are helping ...still keeping up with the B-12 program, which is very beneficial...next week will visit a holistic dentist to discuss the mercury tattoo I have above my front tooth. Will bring you up to date then. Take Care, my Friend....GinnyB
    keishainu 25 Replies Flag this Response
  • I am on methadone because of a drug addiction and i take 120mg per day. Last dec I went to the er due to extreme pain in the abdomin that was the worst pain I ever felt and I really couldn't talk,just cry so when they were going to give me an iv for the pain,I didn't ask what it was and it happened to be nubain,10mgs at that (after a few unseccessful shots of morphine) and I went into straight withdrawl,like you've never felt b4. It was the worst detox i've ever felt in my life and I wouldn't wish it on anyone,not even my worst enemy. It took 3 nurses/drs to hold me down to put the IV back in my arm since I ripped it out when I was in the withdrawl.I literally almost died because when I was in the withdrawl,my friend told them I was taking methadone and so they decided to start giving me all kinds of opiates in the iv to calm me down. They ended up giving me 4shots duladid,4more of morphine and I eventually passed out. I was high for 3 days! It was horrible. I'm so lucky i'm alive forreal and i'm only 27 so that would have sucked. Anyway, you have to be 100% aware of what meds they are trying to give you when on methadone,just for that reason alone. If anyone wants to know more about methadone please get intouch. I've learned alot but also if you have good knowledge of methadone,please get intouch with me aswell because I love to learn all I can about the med i'm on.Thanks and god bless.Debbabidolli22@aol.com
    Anonymous 42789 Replies
    • October 10, 2009
    • 02:24 AM
    • 0
    Flag this Response
  • I had been going to a dr. that was prescribing methadone. I started on 160 mg per day and dropped 10 mg per month until I was taking 110 mg per day. The dr.'s plan was to drop me like this until I was at 30 mg and then I would go to saboxone or detox completely. I went to my last visit with him and he cut me off completely, cold turkey from 110 mg to nothing. He wrote me 120-50mg ultram and 21- 1mg xanax. That was it. He did this because the DEA visited him and he had gotten in trouble. He cut all of his methadone patients off cold turkey like this. (Would like to know if there is anything illegal about this). Yesterday, I went to a new doctor in hopes of getting back on track. Of course I was sick and I NEEDED some relief. The doctor gave me a shot. I had only taken 40 mg of methadone in 5 days. The shot, I later found out, was nubain. Even with my methadone level lower than usual, I was in withdrawals within 15-20 minutes. It was horrible. I was already on my 1 hour drive home. I made it home and applied phenergan gel to my wrists and took advil pm for the pain and sleeplessness. I woke this morning feeling a little but still with slight withdrawl symptoms.
    Anonymous 42789 Replies Flag this Response
  • Hi, Sorry to hear of your experience....why are you taking such high dosages of methadone? I have CFS/FMS and use only 10mg's am and pm...however, I also use Oriental Medicine to compliment the western use of drugs. If you are trying to detox, I strongly suggest getting in touch with a good Oriental Practitioner...they use accupuncture, healing massage and herbs to correct the body system...I send you Blessings for courage and strength if you are battling addiction....stay strong..let me know how you are doing...GinnyB
    keishainu 25 Replies Flag this Response
  • It has been a while since this happened to me. I think it was around 1-1/2 years ago. I have never seen the doctor again that did this to me and it was very hard not to talk to a lawyer about it. I have been thankful for the relief methadone has given me from my pain. I have taken methadone for about 8 years now. I was actually able to work for several extra years because the methadone helped me that much. I have tried several of the other pain narcotics but I feel most comfortable with the methadone. It does not give me any of the "high" feeling some of the others did. The only one that helped me more was the fentanyl patches (I was allergic to the adhesive). From what I understand about methadone it coats all the pain receptors in the brain. When certain other pain meds are given it knocks the methadone off those receptors and causes a several rapid detox reaction until the methadone is replaced on those receptors. I am not positive this is accurate but it was the only thing I was able to find that made any sense out of what happened to me. This had to be one of the most horrible experiences of my life. I was in pain for over a week due to the muscle cramps and evacuation of all my body fluids for so many hours.The doctor kept me in his office for over 6 hours until I was able to walk out on my own and drive myself home. If I had gone to the ER they could have given me IV methadone and it would have only been an hour or maybe two of the severe withdrawal.I have been so afraid of any injections since this happened to me. When taking methadone it is important to find out anything you are being injected with and for the medical professionals to know you are on methadone. I have safely been given morphine and a medication that begins with a D after several surgeries this last year where I had to have injectable pain medication.I know who he was covering when he did not get me to the hospital!!! He has been in trouble for different things for years. I was so hurt that he would let me suffer like that and just send nurses to check on me every hour or so. I thought doctors were suppose to try to stop suffering and pain not just watch it after they have caused it. It seems like he would have called the ambulance and insisted I go to the ER. I found out I could have died from this because of all my medical problems.I recomend you get a medical alert bracelet that lists methadone on it and was tole by one doctor that I should list nubain and stadol as allergies while on methadone.Best wishes!Tricia hi, i just happend to come across this while i was searching stadol interactions and wanted to post my story somewhere even though this post is old.... i take mathadone for opiod dependance. I was pregnant with my second child and went to hospital to deliver. My dr. was not there of course, and i got some stupid ******e...I was suppose to get an epidural. I knew i could not have Stadol, i had a medical card that stated that and i showed him and he said' well i refuse to give you an epidural, and our pharmacist says you can have stadol so take it or leave it, thats all you get'. He discriminated against me because i was on methadone. I was desperate, had a very hard delivery and labor, thought i would die, and i almost did.....the nurse unwillingly gave me the injection(she knew i couldnt have it) and sure enough i went into immediate withdrawal, severe burning skin, loss of consciousness even, respiratory distress . I went from 5 cm dialated to 10 in 1 1/2 minutes and started pushing and then i couldnt breathe. my boyfriend was slapping me to keep me conscious.....it was so bad, the pain all over my body, i wanted to die. And it was all due to that ignorant doctor who thought he knew everything and would play God....should have sued him, but i knew he would win. They always do.
    Anonymous 42789 Replies Flag this Response
  • On 9/7/14 my husband was given nubain for a migraine. The doctor knew that he is on 100mg of methadone but still gave the shot and said it would be fine. Within 15 minutes he was convulsing, thrashing, seizing, violently vomiting, and saying he was dying. I rushes him back to the ER the same doc told us he was reacting to the combination of the two meds. They had to give my husband Valium and morphine for over 5 hours to get it to a manageable level of discomfort. After 8 hrs we got to go home.
    Anonymous 1 Replies
    • October 10, 2014
    • 07:35 PM
    • 0
    Flag this Response
  • I had one of the most HORRIBLE days in my life. I already have severe spinal pain and I was placed on Methadone.
    Occasionally when my pain reaches a high level the muscles in my neck tighten up.
    This led to a horrible kink in my neck in which I couldn't move right arm and the pain in my thumb and fingers was bad. I am on Methadone 80 mgs per day. My doctor KNEW this Very WELL. I couldn't even straighten my neck it was so dang bad or raise my arm.
    Well this doctor (Dr. Patrick Wetovick) prescribed a shot of Nubain. SURELY he would know that Nubain acted similar to Naltrexone --- a drug that basically SHUTS off all Opiod Receptors and makes the Methadone completely Quit working and puts a person in instant withdrawal. Why would he do this? Am I just a Guinea Pig to "Practice Medicine" on?
    So: I was sent home and went to lie on the couch, and all of a sudden I begin smelling sounds --- I know this doesn't make a bit of sense. I started tasting Metallic like substance. Then
    Anonymous 1 Replies Flag this Response
  • Nebain saved my life I had been on 90mg of methadone for 10 years one day I decided to inject an extra 120mg on top of that I overdosed my friend gave me CPR till the Paramedics got there my friend had told them that it was a methadone overdose but they thought it was heroin so they gave me Adrenaline When that didn't work Nubain brought me out of it t needless to say I don't do that no more I have detox down to 17mg of methadone and still going down
    Anonymous 1 Replies Flag this Response
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