I have had major depressive episodes as far back as the age of 15 (I'm 39 now). When I was in my 20's I was actually diagnosed with clinical depression and I've been taking anti-depressants (of all kinds) ever since.
The thing with me is that sometimes I have a weak feeling in my body but I don't think of it as normal fatigue. It isn't always consistant with my depressive episodes. I can be depressed and not have the weak feeling or I can have the weak feeling and not be depressed. I remember as far back as the age of 18 having this feeling. The docs would tell me it was stress and I just needed to exercise. I excercised and felt the same or worse.
To me it feels likes it's in my blood.. like everywhere my blood goes I feel weak. There is nothing that takes the feeling away even laying down doesn't make it go away. At times when it gets bad and my doc switches my anti-depressants it will improve but it always comes back.. and it's unpredictable, I never know when it's coming. Except the one consistency is that I usually have that feeling one day before my period.
I have had my thyroid tested a billion times and all the other "normal" blood tests. I had high levels of ANA's but went to a rhuematolgist for a year. He ruled out Lupus, chronic fatigue, fibromyalgia.. and everything closely related. In fact I would sit in his office feeling like I was going to die and he told me everything looked fine.
I think that this isn't just depression. I think I have something else going on but I have no idea what it could be. Any thoughts?