Does anyone know the effects of taking antibiotics when an undiagnosed Aspergillus infection is present in an already immunosuppressed person would do?
My step father, who had AML presented at hospital with back and abdo pain along with constipation. Xray images should lesions on the spleen and liver. Later a further review of the xray located what was described as a small incidental aneurysm on the celiac artery. It was also found that the aneurysm was mycotic. Without further investigation of the infection within the aneurysm or the origin of the lesions on other organs, the medical team commenced antibiotic therapy.
Later on in hospital he experiences chest pains. The hospital carried out an ECG and found that there was no myocardiac infaction so they put in down to angina.......... Some weeks later they found he had pneumonia but stated that the antibiotic therapy would have covered this.
No long after, a cyst on one of the splenic lesions was drained and found to contain the Aspergillus fungi. We were advised that the nature of the Aspergillus was to basically try to eat its way through the artery wall. By the time antifungals were prescribed he never responded and the medication with drawn.
What I really want to know is, would the antibiotics have made the infection worse and would have earlier antifungal intervention have made much of a difference?