Discussions By Condition: Medical Stories

Effexor xr + Marijuana Usage = Delirium

Posted In: Medical Stories 33 Replies
  • Posted By: Anonymous
  • July 25, 2007
  • 06:42 AM

I have a very long story. Currently i am taking effexor xr anti depressant. I am a 21-year-old male who was a typical smoker. I have recently stopped while taking effexor due to some bad experiences i had while combining the two.

It started out one night over my friend’s house where we usually hang out and smoke and have a good time. This night i had increased my dosage of Effexor as prescribed from 75mg to 150mg. I smoked marijuana that night just like many other nights prior to this one. After smoking more and more i began to feel very different. My mind eventually started to scramble and nothing would make sense to me. I was unable to interpret anything people were saying around me and it made me very confused and scared like i was trapped in a dream. First thing i remember is having an out of body experience. I felt like my mind had left my body and i was sitting on the couch trying to fight myself to come back into my body. My friends say i was spinning in circles at this stage. I was head-butting my friends cousin who was sitting on the couch next to me. My friend yells, " quit head butting my cousin before i punch you!" I was not aware of this as i was out of consciousness. I head butted her yet again and she got up off of the couch very scared. My friend decided thought i was just being a dickhead to his cousin so he slammed me into the couch. He told me i had no resistance to him shoving me into the couch and knew something was not right. At this point i was coming in and out of consciousness not knowing exactly what was going on around me.

I then thought I was dying. I felt my heart pounding through my chest and I was very hot. After fighting hard to try and get back into my body by spinning my body the opposite direction I then was back in reality for a brief moment. Id say what just happened? As soon as my friend would start telling me about it, id suddenly go back into relapse and go back out of consciousness once again. This time my back started to arch very hard and I could feel my back muscles tense up and become really tight. Shortly after that I then felt as if it was hard to breathe. I came back into consciousness and told my friend I needed water and ice. Lots of ice I told him. Then he tells me we don’t have any ice, so he gets me an ice pack from the freezer. I take the icepack and start to bite it. I bit the icepack so hard that my friend told me he heard the ice inside the icepack break. This whole time I was very unaware of what I was doing, but only snapping into reality every few minutes. After drinking the water he gave me, I then felt like I was drowning in a pool of water. My mind thought that maybe I was dying and drowning at this very moment. So I felt as if I was drowning. I had just gargled the whole bottle of water down the front of me and I was soaked. I didn’t know at the time because I was not all there. I then felt as if I had to use the restroom. As I got in there I tried to urinate but I couldn’t get my mind focused enough to do so. It was so hard to fight against my mind to try and concentrate on one particular thing. As my friends are helping me walk back into the room to sit on the couch I pass out of consciousness again. I fell to the floor. I began to have a seizure. My friend grabbed my tongue, and tries to wake me up. I woke up and did not know where I was. My two friends helped me stand up and asked what I took that day. I said nothing. They said you had to take something are you on triple c’s (choricedine cold and cough medicine) I said yes, that. They didn’t take me to the hospital because they thought id be fine when they wore off. But I have never taken those before. I fell out of consciousness once again and I remember visualizing events that happened weeks ago start to flash very fast in my mind. I remember clenching up very tight and my heart pounding even harder now…harder…. harder with every beat. I thought to myself this is it im dying. My friend said I struggled to get it out and said “im dying dude”…”im dying”. He said your not dying just relax… I felt extreme pressure on my chest like my heart was about to explode. I had my eyes closed and say a bright light and remember thinking to myself I don’t want to die if this is it im not ready. The light became brighter and brighter. So bright it hurt my eyes to keep them shut. As I opened my eyes everything was fine and calm. I woke up and was conscious again. My heart was beating normally and there was no bright light in the room. I sighed in relief. I asked my friends in the room what happened? They said I wigged out and started doing crazy ****. I asked what did I do? And they started telling me everything. Two hours had gone by, and it felt to me like 10 minutes, if that. I was very confused, and still feeling a little high from smoking. It hadn’t wore off completely yet. As the night went on I did feel as what I know as delirious episodes from time to time… but when the high wore off, they stopped occurring.

The next morning I felt relieved and very happy. I was happy the whole day knowing I was alive and it was all just a bad experience. I didn’t know what happened to me that night.

I thought that just maybe it was just because I had upped my dosage so much.

A few nights later I was smoking again. But not as much as normal. Nothing like that had happened.

A few nights more I smoked again, and another similar episode occurred. I find out that if I get high while on effexor xr (any amount dosage) I have these episodes and my brain pretty much scrambles. I experience extreme confusion and delirious states of mind. I told my doctor about it and he advised me to stop smoking. I am clean now and haven’t touched it in 2 weeks to this day and feeling better.

I am not very religious but I think now that someone is looking over me and giving me another chance.

Anyone else experienced these symptoms or interactions with combining the two drugs? Please let me know if you have because I’d love to hear about your experiences.

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33 Replies:

  • I think you Od'D and had a near death experience. Given a second chance, why not give up on drugs altogether, or is that life style worth sacrificing your life for?
    Monsterlove 2921 Replies Flag this Response
  • i did stop using drugs all together...effexor xr is an anti-depressant. this just recently happened and ive been clean for about 2-3 weeks now. You cannot OD on marijuana anyways.
    Anonymous 42789 Replies Flag this Response
  • That's what you think...you don't know what pesticide they've sprayed on it...when you are young, too, "friends" have been known to put LSD in the joint for another high...glad you quit...keep up the good work. Meditate now..do yoga..
    Monsterlove 2921 Replies Flag this Response
  • I am a PTSD patient with acute axiety disorder and severe depression, and I have a doctor's prescription to smoke pot legally. I was prescribed effexor xr by another doctor, tried it, and hated it. It made me feel as if my brain was being "blocked off" so to speak. I felt disconnected. violent and borderline pschopathic. I never took it again, and I am now very wary of man-made pschotropic medications. I legally grow my own high-potency marijuana and I've found it is by far the best medication available for my conditions. IN POT + MUSIC I TRUST
    Anonymous 42789 Replies
    • November 23, 2007
    • 03:49 AM
    • 0
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  • I had similar experiences with effexor XR and weed when I was younger. I just came across a lot of these posts about the combo of the two recently, but at the time I had no idea that there was a possibility of interaction.I used to lose my F-ing mind to the great amusement of my buddies. I would have psychedelic experiences like comprehending what it was like to be other people, animals, then inanimate objects like rocks and plants. It's weird and hard to explain. Eventually I would "forget what it was like to human." Which made everybody really crack up. It started happening frequently. I would begin to imagine being all those other things and eventually forget how to be myself (behavior, feeling, ect). Simply speaking I experienced a lot of really intense highs that lasted a really long time. I'm talking like sharing a bowl in a car around 5ish and being high until I fell asleep at my house in a crazy state at god knows what time in the morning. Some highs were fun in spite of all that, I'm the type of person who can maintain under the influence (and that was definitely good training). Sometimes the highs were very bad. I occasionally had panic attacks, I vomited twice, mixing alcohol was a disaster, and I could NEVER sleep. I don't sleep often anyway, but with weed its impossible. And like I said, it never occured to me that I was experiencing an interaction effect. I was a new smoker. Effexor effects people very differently and so does weed. Kids need to know that there is a good possibility of them getting really ****ed up if they try this. It's sad that a lot of them will probably end up like me. Good Luck, your in for some super mind-**** experiences.
    Anonymous 42789 Replies
    • October 6, 2008
    • 06:00 PM
    • 0
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  • Monsterlove, LSD would be completely destroyed if you smoked it on bud.
    Anonymous 42789 Replies
    • January 24, 2009
    • 06:50 AM
    • 0
    Flag this Response
  • I just had to reply and say I had an experience just like this, although at the time I wasn't even taking effexor. I had been smoking pot generally every day for a long time when suddenly one night I was smoking with my friends, a regular amount, and I had an episode just like that. It was probably the scariest experience of my life. I kept telling my friends "I didn't know who I was" and life seemed so strange, just the concept of being alive, and it ****ing scared me. I couldn't picture myself as a person and kept feeling as if I was going to die (I thought I was having heart attacks and strokes). This went on for maybe an hour and a half before I could feel somewhat normal again. I also kept feeling like I was going to go crazy and I would have this EXTREMELY intense pressure in my head that kept feeling like my brain was going to explode (I actually kept telling my friends "okay .. this is it .. im gonna die in about 5 seconds"). I’m not religious either but I felt like there was this other ‘power’ talking to me and I kept saying I swear I swear I swear I’ll never smoke weed again. Even though I’m not against it and it’s not like my life has changed because of smoking it. But I felt like I had to keep promising the ‘power’ that in order to get through the episode. So yeah after this I realized I'd been having mini episodes like this all the time and they were really starting to bother me. I started getting them more and more (when completely sober) and my doctor told me i have panic disorder and put me on effexor. and now apparently when you smoke weed ON effexor the panic attacks are even worse :( which sucks :( Although the other day I took just two small hits and I felt fine, although I really don't want to test my limits.
    frecklednose 1 Replies
    • January 29, 2009
    • 09:46 PM
    • 0
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  • I had the same kind of experience. It was the most terrifying experience of my life. I'm on the 75mg 2 a day dose of effexor. I typically have a hard time remembering to take my pills, so I sometimes take them really late or not at all. My wife and I smoke up every now and then, maybe twice a month at most, and thinking back, I recall missing doses every time I did, because I realized I missed it after the fact and didn't want to have a bad combo reaction. But the last two times I smoked, I had taken my second dose late and lost my f***ing mind.I felt disconnected from myself, and every sound and thought was intense, persistent and yet fleeting. Then I realized I was 'unstuck in time' and had to get myself back somehow. It hurt within my soul, being disconnected from reality like that. My wife tried to get ahold of me to calm me down, and due to PTSD from a horrible childhood, holding me down is the last thing that should have been done. This sent my panic to new highths and I was having screaming seasures on the floor, swimming away from her.I couldn't get a fix on anything, or what she was saying to me, all I knew was I had to get out and scream and tell everyone, because someone had to help me get back into time or I was going to die and be unstuck forever.Time had no meaning for me, what was two hours seemed like ten minutes, and there were two brief spots of simi-awareness. Then I finnally got enough self awareness to get up and have her help me to bed. the twitches and spasms started and I couldn't stop them. she kept telling me to stop moving. This reverberated and repeated itself in my mind over and over, becoming the negitive, oposing force to my positive force. i began to spin, twist, merge, and become the universe, I was the positron and electron of the begining of the universe, trying to bring the universe out of pure chaos. Thoughts were so incoherent I'm not sure where I went from there.The strange thing is that exactly five hours and fifteen minutes after i took my dose, I just popped out of it. It was terrifying.I had no idea what had happened, until the exact same experience happened to me the next smoke. then it all came to gether and I knew exactly that this was the problem. after looking into it online, effexor is a seritonin inhibitor and cannabis stimulates it, this causes such a mixed signal in the brain that you really are having a mini stroke or seasure. NOT A GOOD COMBONATION!
    Anonymous 42789 Replies
    • January 31, 2009
    • 05:16 AM
    • 0
    Flag this Response
  • Yea i had a horrible experience the other night similar to what you described. Been a pot smoker for a long time and was prescribed a very low dose of effexor for my anxiety. Took a huge rip of super high grade kush and boom. My heart started to pound, sweating and then my body went totally cold. I though to myself, wow i really screwed up now. Ran straight to the cabinet and sucked on a couple of sugar cubes and then a few mins later i was fine. These two drugs DO NOT MIX!!! CHOOSE ONE
    Anonymous 42789 Replies
    • February 3, 2009
    • 04:48 AM
    • 0
    Flag this Response
  • jack you say you feel like someone gave you a second chance.i am going through a similar thing right now and i wanted to tell you for me and youthat you gave YOURSElf a second chance
    Anonymous 42789 Replies
    • February 14, 2009
    • 02:08 AM
    • 0
    Flag this Response
  • dudes, i'm 19 and i've been taking effexor xr 75mg a day, this is my 3rd week and all last week seeing as I got 2 weeks off by the doctor to "adapt" to the anti depressant, i smoked weed for about 5 days straight. i haven't had any problems, i was fine. i'm not a heavy weed smoker at all. i do it occasionally with friends and sometimes that isn't even every week. but those 4-5 days that I did smoke i was completely fine.i researched the effects it can have mixing the two drugs before I mixed them, and I read all about things like this yet nothing occurred. I guess i was lucky or just know how to pace myself? anyway, everybody reacts differently. I take my medication at about 4pm everyday and don't smoke for an hour after it because that's when it is kicking in (in that hour??) so if you're going to do it, my advice is to pace yourself and don't rush anything. everybody reacts differently. i certainly did and i'm sure there's more people who did aswell.and kudos to that dude who mentioned weed and music! weed helps me write amazing lyrics. ahhhhhhh!!! it's an amazing drug if you don't depend on it/excessively use it!
    Anonymous 42789 Replies
    • February 23, 2009
    • 06:53 PM
    • 0
    Flag this Response
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  • I have just recently started taking Effexor XR 110mg a day. This is now my eighth day on the drug and everyday I have smoked pot. I smoke on average 6 bowls so almost 3 blunts a day and have had none of those effects. Right after I smoke, things slow down, music sounds better, I take better notes in class, and am extremely calm. My heartbeat doesn't do anything out of the ordinary and I think those effects other people got were strictly their own. There are a lot of people on this stuff and it seems like only a handful post anything, the only ones that do are the minority that had bad side effects. I enjoy it's effects, it's made me a better person, and I plan on keeping my lifestyle the exact same forever.
    Anonymous 42789 Replies
    • February 26, 2009
    • 02:09 PM
    • 0
    Flag this Response
  • I've been taking Effexor and heavily smoking marijuana for years. I'm on 150mgs of Effexor and have never had a reaction like that, except when I had my first panic attack. I had smoked a bowl of White Widow (a strain known for it's possibility to cause anxiety in some) after a fun night out with the girls, and after that I had to be taken to the hospital. To me it sounds as if the Effexor is causing the awful reaction, not the weed. Especially if you had never had an episode of such magnitude when not taking Effexor. I'm terrified to get off of this "medicine" since I hear it causes worse side effects than heroin withdrawl. The only thing that may help, is the natural beautiful weed that grew wild until the government wanted to get rid of all the Mexican immigrants "stealing" american jobs during the great depression, and proceeded to make marijuana illegal since it was the Mexican's bringing it into the US...even though people smoked it before that...If nature helps more than the crazy pharmaceuticals that barely educated, money hungry drug companies prescribe..stick with it. Don't start Effexor unless you're going to die without it...you'll never be able to stop taking it without major withdrawls that last for months...Sorry to those of us trapped in the Effexor cycle...
    Anonymous 42789 Replies Flag this Response
  • I have a very long story. Currently i am taking effexor xr anti depressant. I am a 21-year-old male who was a typical smoker. I have recently stopped while taking effexor due to some bad experiences i had while combining the two. It started out one night over my friend’s house where we usually hang out and smoke and have a good time. This night i had increased my dosage of Effexor as prescribed from 75mg to 150mg. I smoked marijuana that night just like many other nights prior to this one. After smoking more and more i began to feel very different. My mind eventually started to scramble and nothing would make sense to me. I was unable to interpret anything people were saying around me and it made me very confused and scared like i was trapped in a dream. First thing i remember is having an out of body experience. I felt like my mind had left my body and i was sitting on the couch trying to fight myself to come back into my body. My friends say i was spinning in circles at this stage. I was head-butting my friends cousin who was sitting on the couch next to me. My friend yells, " quit head butting my cousin before i punch you!" I was not aware of this as i was out of consciousness. I head butted her yet again and she got up off of the couch very scared. My friend decided thought i was just being a dickhead to his cousin so he slammed me into the couch. He told me i had no resistance to him shoving me into the couch and knew something was not right. At this point i was coming in and out of consciousness not knowing exactly what was going on around me. I then thought I was dying. I felt my heart pounding through my chest and I was very hot. After fighting hard to try and get back into my body by spinning my body the opposite direction I then was back in reality for a brief moment. Id say what just happened? As soon as my friend would start telling me about it, id suddenly go back into relapse and go back out of consciousness once again. This time my back started to arch very hard and I could feel my back muscles tense up and become really tight. Shortly after that I then felt as if it was hard to breathe. I came back into consciousness and told my friend I needed water and ice. Lots of ice I told him. Then he tells me we don’t have any ice, so he gets me an ice pack from the freezer. I take the icepack and start to bite it. I bit the icepack so hard that my friend told me he heard the ice inside the icepack break. This whole time I was very unaware of what I was doing, but only snapping into reality every few minutes. After drinking the water he gave me, I then felt like I was drowning in a pool of water. My mind thought that maybe I was dying and drowning at this very moment. So I felt as if I was drowning. I had just gargled the whole bottle of water down the front of me and I was soaked. I didn’t know at the time because I was not all there. I then felt as if I had to use the restroom. As I got in there I tried to urinate but I couldn’t get my mind focused enough to do so. It was so hard to fight against my mind to try and concentrate on one particular thing. As my friends are helping me walk back into the room to sit on the couch I pass out of consciousness again. I fell to the floor. I began to have a seizure. My friend grabbed my tongue, and tries to wake me up. I woke up and did not know where I was. My two friends helped me stand up and asked what I took that day. I said nothing. They said you had to take something are you on triple c’s (choricedine cold and cough medicine) I said yes, that. They didn’t take me to the hospital because they thought id be fine when they wore off. But I have never taken those before. I fell out of consciousness once again and I remember visualizing events that happened weeks ago start to flash very fast in my mind. I remember clenching up very tight and my heart pounding even harder now…harder…. harder with every beat. I thought to myself this is it im dying. My friend said I struggled to get it out and said “im dying dude”…”im dying”. He said your not dying just relax… I felt extreme pressure on my chest like my heart was about to explode. I had my eyes closed and say a bright light and remember thinking to myself I don’t want to die if this is it im not ready. The light became brighter and brighter. So bright it hurt my eyes to keep them shut. As I opened my eyes everything was fine and calm. I woke up and was conscious again. My heart was beating normally and there was no bright light in the room. I sighed in relief. I asked my friends in the room what happened? They said I wigged out and started doing crazy ****. I asked what did I do? And they started telling me everything. Two hours had gone by, and it felt to me like 10 minutes, if that. I was very confused, and still feeling a little high from smoking. It hadn’t wore off completely yet. As the night went on I did feel as what I know as delirious episodes from time to time… but when the high wore off, they stopped occurring. The next morning I felt relieved and very happy. I was happy the whole day knowing I was alive and it was all just a bad experience. I didn’t know what happened to me that night.I thought that just maybe it was just because I had upped my dosage so much.A few nights later I was smoking again. But not as much as normal. Nothing like that had happened.A few nights more I smoked again, and another similar episode occurred. I find out that if I get high while on effexor xr (any amount dosage) I have these episodes and my brain pretty much scrambles. I experience extreme confusion and delirious states of mind. I told my doctor about it and he advised me to stop smoking. I am clean now and haven’t touched it in 2 weeks to this day and feeling better.I am not very religious but I think now that someone is looking over me and giving me another chance. Anyone else experienced these symptoms or interactions with combining the two drugs? Please let me know if you have because I’d love to hear about your experiences.i smoke marijuana everyday of my life, and have been taking 150 mgs of effexor xr for three years.i am only sixteen years of age.before i started smoking, i would take the effexor regularly, and all it did was make my body feel honestly numb, i was unable to feel any kind of emotion, and i hated it.i got sick several times a week because of trying to ween myself off of them, obviously not such a good idea.so i realized that the effexor xr was lowering my "high" from marijuana and realized i was wasting my money. you describe in the above paragraph that your mind scrambled and i find you pathetically desperate for attention by saying that.effexor xr minuses the effect of the marijuanaand the marijuana minuses the effect of the effexor xr.it took me years to realize that its a lose, lose situation.
    Anonymous 42789 Replies
    • August 24, 2009
    • 05:23 AM
    • 0
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  • That's what you think...you don't know what pesticide they've sprayed on it...when you are young, too, "friends" have been known to put LSD in the joint for another high...glad you quit...keep up the good work. Meditate now..do yoga..your just stupid, even if there was lsd in the cannabis the combustion in itself would destroy the lysergic acid not allowing for a psychedelic effect, also despite weed being an underground commodity 99.99999% of it is safe and your point only adds more to the argument that it should be regulated and taxed similar to alcohol and tobacco then there would be no doubt that the said cannabis is pure
    Anonymous 42789 Replies
    • October 6, 2009
    • 06:26 PM
    • 0
    Flag this Response
  • I have been on Effexor for awhile and am on 150 mg right now as well. I am a somewhat alcoholic and drinking really messes with me, and I'm sure you know. My doctor told me to stop, so I've been trying to quit. I recently started smoking weed though, thinking it wouldn't be as bad. I still don't know, because I've never smoked weed off my pills. But I had a similar out of body experience. My mind also feels scrambled, going in circles and circles and over analytical. At the same time I feel so relaxed, and everything makes more sense. But my high lasted a good 10 hours, I don't know if that's normal. I came across your story when looking up side effects of smoking on effexor.
    Anonymous 42789 Replies
    • November 1, 2009
    • 09:02 PM
    • 0
    Flag this Response
  • So Im takin 150 right now and I actaully just smoked a bowl then took it. Well thinkin about it I decided to gogle and wond up here. lool. Anywho I havent noticed and effects like delerium so far but I have felt pretty messed up. Its kinda puts evverything up a stage and make you feel a whole hella of a lot higher. Im not sure what else I would need to experiment more but nothing significant. Anyway yeah cool **** have a good one.
    Anonymous 42789 Replies
    • November 21, 2009
    • 07:50 AM
    • 0
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  • i've def had some of the same symptoms from smoking while being on effexor xr; i'm taking 250 mg, and have been for the past 2 years for severe depression, and anxiety. Before being on it i smoked once a week maybe sometimes less. i had gone threw a really bad low before taking it so wasn't really smoking or being social to get any for the first few months or didn't smoke 'enough' to get any really twisted effects. but there was this one night i went out with a guy friend of mine i was talking to and known for some time and completely lost my mind. i had also taken a vicodine which didn't help my deliria what so ever. we had a water bong (which i've had no problems with before), it was me and one of his buddies.... everything was cool at first then my mind just tripped downwards.. it was like someone hit repeat and i keep hearing and seeing the same thing over and over again and suddenly i fell back they told me later i looked like i was having a seizor.... while i was in that state i was having the wildest hallucinations, i felt like i was in a movie. laying there i couldn't come back in to reality; my mind was running a million thoughts a second and my body felt limp.. i thought i was a victim of some type of organ harboring & they we're getting ready to cut me open.. all of a sudden my hallucinations would turn and i'd see my self out of body- i felt like and saw myself as a fish with no air flopping on the deck(bed in this case i was on a bed) as i saw myself flopping i thought i was being raped,(a large part of my depression comes from sexual abuse) my mind was playing back how i could have got in this situation like a movie it was so unreal. as i would go back in to time reviewing what i thought was happening i can hear them in the back round as if i was the *********e of there one night stand that had gone wrong, contemplating weather or not they should call a ambulance for my aid. i can't think of what had triggered me to left up or what was going threw my head but i came back into my body and consciousness sitting up then a rage came across me i looked and my guy friend like i was ready to kill.. (now i can understand the feeling that comes across those who are abused and really do) i snapped out of it, still thinking my hallucinations were real i play along with them like nothing happend.. i'm still under the impression that they are trying to kill me... my mind is hearing them in slow motion them telling me why i feel the way i do but it still doesnt seem real.. as they are telling me it's repeated and i translate it into paranoia for my life. i feel one of them behind me or about to touch me and think they have a knife and are ready to cut each of my limbs off... my body still numb from the vicodine, i'm afraid when i get up my body will just fall apart... scared for my life i bolt up running out of the apartment with nothing but the clothes on my back and bare feet in the winter screaming for the heavens or movie set to open up. to wake up. anything. as i'm running they try to find me so they can bring me to the e.r. which wasn't to far and i agree.. still not knowing weather or not to trust them. once i get to the e.r. i jump out of the car run to the hospital and almost jump behind the counter to get away.. as they admit me i continued to have panic attacks and dilutions thinking i'm dying; going insane. by the time i finally chilled out my eyes almost closed from swelling of my sobs, and given handfulls of pills to knock me out sleeping the rest of the day away. i never knew what happened that day until a similar but MUCH less accurance without hallucinations of this happened almost 6 months later with a few close friends. i've smoked and used other drugs plenty of times but NEVER was the result as insane as the times i've smoked while being on effexor. SCARIEST day of my life.
    Anonymous 42789 Replies
    • November 23, 2009
    • 05:58 PM
    • 0
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  • The 5 best treatments in this world are spiritual cure, herbal therapy, natural health therapy, acupuncture and thermogenesis. They are safe, effective, leisureable and pleasurable. I have a very long story. Currently i am taking effexor xr anti depressant. I am a 21-year-old male who was a typical smoker. I have recently stopped while taking effexor due to some bad experiences i had while combining the two. It started out one night over my friend’s house where we usually hang out and smoke and have a good time. This night i had increased my dosage of Effexor as prescribed from 75mg to 150mg. I smoked marijuana that night just like many other nights prior to this one. After smoking more and more i began to feel very different. My mind eventually started to scramble and nothing would make sense to me. I was unable to interpret anything people were saying around me and it made me very confused and scared like i was trapped in a dream. First thing i remember is having an out of body experience. I felt like my mind had left my body and i was sitting on the couch trying to fight myself to come back into my body. My friends say i was spinning in circles at this stage. I was head-butting my friends cousin who was sitting on the couch next to me. My friend yells, " quit head butting my cousin before i punch you!" I was not aware of this as i was out of consciousness. I head butted her yet again and she got up off of the couch very scared. My friend decided thought i was just being a dickhead to his cousin so he slammed me into the couch. He told me i had no resistance to him shoving me into the couch and knew something was not right. At this point i was coming in and out of consciousness not knowing exactly what was going on around me. I then thought I was dying. I felt my heart pounding through my chest and I was very hot. After fighting hard to try and get back into my body by spinning my body the opposite direction I then was back in reality for a brief moment. Id say what just happened? As soon as my friend would start telling me about it, id suddenly go back into relapse and go back out of consciousness once again. This time my back started to arch very hard and I could feel my back muscles tense up and become really tight. Shortly after that I then felt as if it was hard to breathe. I came back into consciousness and told my friend I needed water and ice. Lots of ice I told him. Then he tells me we don’t have any ice, so he gets me an ice pack from the freezer. I take the icepack and start to bite it. I bit the icepack so hard that my friend told me he heard the ice inside the icepack break. This whole time I was very unaware of what I was doing, but only snapping into reality every few minutes. After drinking the water he gave me, I then felt like I was drowning in a pool of water. My mind thought that maybe I was dying and drowning at this very moment. So I felt as if I was drowning. I had just gargled the whole bottle of water down the front of me and I was soaked. I didn’t know at the time because I was not all there. I then felt as if I had to use the restroom. As I got in there I tried to urinate but I couldn’t get my mind focused enough to do so. It was so hard to fight against my mind to try and concentrate on one particular thing. As my friends are helping me walk back into the room to sit on the couch I pass out of consciousness again. I fell to the floor. I began to have a seizure. My friend grabbed my tongue, and tries to wake me up. I woke up and did not know where I was. My two friends helped me stand up and asked what I took that day. I said nothing. They said you had to take something are you on triple c’s (choricedine cold and cough medicine) I said yes, that. They didn’t take me to the hospital because they thought id be fine when they wore off. But I have never taken those before. I fell out of consciousness once again and I remember visualizing events that happened weeks ago start to flash very fast in my mind. I remember clenching up very tight and my heart pounding even harder now…harder…. harder with every beat. I thought to myself this is it im dying. My friend said I struggled to get it out and said “im dying dude”…”im dying”. He said your not dying just relax… I felt extreme pressure on my chest like my heart was about to explode. I had my eyes closed and say a bright light and remember thinking to myself I don’t want to die if this is it im not ready. The light became brighter and brighter. So bright it hurt my eyes to keep them shut. As I opened my eyes everything was fine and calm. I woke up and was conscious again. My heart was beating normally and there was no bright light in the room. I sighed in relief. I asked my friends in the room what happened? They said I wigged out and started doing crazy ****. I asked what did I do? And they started telling me everything. Two hours had gone by, and it felt to me like 10 minutes, if that. I was very confused, and still feeling a little high from smoking. It hadn’t wore off completely yet. As the night went on I did feel as what I know as delirious episodes from time to time… but when the high wore off, they stopped occurring. The next morning I felt relieved and very happy. I was happy the whole day knowing I was alive and it was all just a bad experience. I didn’t know what happened to me that night. I thought that just maybe it was just because I had upped my dosage so much. A few nights later I was smoking again. But not as much as normal. Nothing like that had happened. A few nights more I smoked again, and another similar episode occurred. I find out that if I get high while on effexor xr (any amount dosage) I have these episodes and my brain pretty much scrambles. I experience extreme confusion and delirious states of mind. I told my doctor about it and he advised me to stop smoking. I am clean now and haven’t touched it in 2 weeks to this day and feeling better. I am not very religious but I think now that someone is looking over me and giving me another chance. Anyone else experienced these symptoms or interactions with combining the two drugs? Please let me know if you have because I’d love to hear about your experiences.
    Heal Chronic Illness 18 Replies
    • November 26, 2009
    • 06:35 PM
    • 0
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  • The 5 best treatments in this world are spiritual cure, herbal therapy, natural health therapy, acupuncture and thermogenesis. They are safe, effective, leisureable and pleasurable.To-petesanippleYou are absolutely off base with your comment. There is now way you can down play someones experience as it was not one of your own.I had the EXACT same reaction, but it started before I began the medicine. It was actually the cause of my having to begin meds for anxiety. I toked it up everyday 3 times a day since i was 14, stopped at 18 for a job. I hated parting ways with weed because it was what i used to relax. I started up again 5 months ago ( now almost 21 ) and i had increasingly anxious highs every time. i brushed it off and kept smoking thinking it would taper away. guess what, did the opposite. smoked some REALLY good bud and went into the most terrifying panic of my life and thought i was going to die. next day felt no anxiety but was in this fog and felt disconnected from reality. like an idiot i continued smoking the rest of that week and by the end of it i might as well of got on a space ship and left the planet cause god knows i wasn't here.I had constant social anxiety, confusion, depersonalization, derealization, and panic set in easily for no reason. mind you, this is after i quit smoking, and these feeling continued at varying strengths day to day. I started venlafaxine (effexor) at 175 mg once a day, and it did exacerbated the effects the first couple weeks, which was TERRIBLE. was on the 175mg for 2 1/2 months before telling my doc i had to come off it. went to 75mg, had some withdrawal not completely crippling but defiantly had the zaps.i decided to smoke again to experiment and see if anything had changed (remember i really loved my bud, and wanted my old high back) and that put me into the same trip Jack L. was talking about. completely out of control, struggling with every ounce of will to regain some kind of foot hold on whats going on... and failing. It was now the new worst experience of my life. as of 5 days ago, i am off the venlafaxine and am being to feel much better. some anxiety still but getting better every day since i stopped taking it. i think it may have helped in some small way but i can't be sure. overall i think it was a terrible drug for me. btw withdrawal is ***l.And to those who will inevitably question it, i can completely vouch for the purity of the weed, and it was not laced. I would love to be able to hit a pipe again, but it would prob put me in the loony bin. everyone's brain chem. is different, and it does change as you get older. so don't discredit someones traumatic experience just because you haven't gone though it. i couldn't wish this one on anyone, as death almost sounded sweeter than feeling like that.dont go around being some cynical cannabis martyr, your putting others down to re-enforce your beliefs, wrong or not, and you sound like a Jehovah's witness.
    Anonymous 42789 Replies
    • January 7, 2010
    • 09:39 AM
    • 0
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