I am totally bewildered at this point, and any input would be greatly appreciated. I am a 58 year-old female. At 21 I was tall, athletic, slim, big-busted and attractive. I was 5'8 and weighed 132 lbs. Than things went haywire. I began experiencing dizziness, had fainting spells, and stopped having periods. I developed a lot of body hair, and ended up with a beard that had to be shaved twice a day. I have very fair skin, and this was coarse, black hair. By Christmas I weighed 200 lbs. I went from doctor to doctor, and Cushings was suggested. I was tested, results were negative. I was diagnosed with PCOS (cystic ovaries), high blood pressure, and insulin-resistance (not diabetes), and the only treatment offered was birth control pills for the hormones in them, along with the attendant dangers of possible stroke and heart attack. I decided against them. I continued to gain weight rapidly and topped out at 266 lbs. I have the typical moon face, buffalo hump, huge belly, cartoon breasts and very skinny legs and rear. I was always hungy and thirsty. I was so ashamed at being so fat I went on a crash diet of meat, cottage cheese and water, and managed to lose 66 lbs in about 8 months. My periods started again. About a year ago I began to get really sick. I felt terrible and exhausted and weak. My periods stopped in May, I began a terrible menopause, and 3 months later I had a stroke. I was diagnosed as a diabetic, put on insulin, and had an A1C of 12.5. My doctor put me on the South Beach diet, and I now weigh 176 lbs. My last A1C was 5.6. I am having sweats, can't sleep, adrenalin attacks, etc. I can't rise from a chair without help or climb stairs due to weakness. Exercise is torture. I spend 20 hours a day in bed or on the couch. I am eating very little, just a piece of meat, a small green salad and 2-3 prunes a day. I'm not losing any more weight, and the tiniest bit of carbs makes my weight shoot up. Recently my doctor brought up Cushings again. I was given a 24 hour urine test for cortisol (Cushings) and the Cushings Foundation said a reading of 100 or more was a positive, my doctor said my cortisol was only slightly elevated. When I asked for the actual number, she said it was 246!! Can that possibly be right?? The symptoms other than the weakness have been the same for 38 years, Cushings tests were negative, how can it be Cushings now?? I don't understand. Help, please!