Discussions By Condition: Liver conditions

Oral treatment for chronic Hepatitis B

Posted In: Liver conditions 0 Replies
  • Posted By: satimis
  • July 27, 2009
  • 10:26 AM

Hi folks,


My sister, age 33, discovered lately herself sufferring chronic Hepatitis B. The discovery started from blood test, on early April, 2009, as a condition imposed by an Insurance company on purchasing a plan for medical insurance.


Afterwards she attended Government hospital for another medical examination:

Result of blood test;
Patent Information Sheet for HBV-DNA Assay

Indications for HBV-DNA Assay in CHB patient
Pre-treatment baseline DNA level in CHB patient

Latest Laboratory Results:
HBsAg pos Date: 22/05/2009
HBeAg pos Date: 22/05/2009
HBeAb N/A

ALT level: 239 (ULN=36in/L)

Hospital / Clinic: Medical
Date of Report: 12/06/2009 Then she made another thorough blood test in a private clinic with following result;

Date Molecular Test genetic test Conventional S.I.Unit
Unit Result Result
---------------------------------------------------------------------------------
15/07/2007 HBV DNA Hepatitis B virus quantity 2.1 x 108 copies/mL 4.2 x 107 IU/mL

Ref value Conventional Unit S.I. Unit
-------------------------------------------------------------------------------
Negative: <50 copies/ml <10 IU/ml
Weak positive: 50 – 1.0 x 104 copies/ml 10 - 20 x 103 IU/ml
Positive: >1.0 x 104 copies/ml >2.0 x 103 IU/ml
Remarks:
- Cumulative results will be shown when ID number is provided
- The HBV DNA Quantitation was performed by Real-time PCR. The sensitivity was 50 copies/ml, or 10 IU/ml (i.e. 1 UI/ml – 5 copies/ml). The specificity was greater than 99%
- Reference of this test : Ho SKN et al. Rapid quantitation of hepatitis B virus DNA by real-time PCR using fluorescent hybridization probes J Med microbiol 2003 May:52(Pt 5):397-402
- This report is intended for doctor's reference only


Comment RANDOM
S.I. Unit Conventional Unit
Biochemistry Result Ref.value Result Ref value
Total Protein 71 g/L 63 - 82 7.1 g/dl 6.3 - 8.2
Albumin 41 g/L 35 - 50 4.1 g/dl 3.5 - 5.0
Globulin 30 g/L 22 - 36 3.0 g/dl 2.2 – 3.6
Bilirubin, Total 6 umol/L Up to 22 0.4 mg/dl Up to 1.3
Bilirubin Direct 1 umo/L Up to 7.0 0.1 mg/dl Up to 0.4
Alkaline phosphatase 69 U/L 38 - 126 69 U/L 38 - 126
GGT 55 U/L 8 - 78 55 U/L 8 - 78
SGPT/ALT 449 U/L ** 5 - 52 ↑ 449 U/L 5 - 52
SGOT/AST 231 U/L ** 8 - 39 ↑ 231 U/L 8 - 39
She is now under the care of Government hospital. The doctor, in-charge her case, proposes following treatment;

One year injection (4 bottles/mth x 12 months) = 48 bottles

peginterferon alfa-2a, lamivudine combination for HBeAg - Positive Chronic Hepatitis B

Comment by Doctor:-
Chance of recovery = 2~3%


Further opinion sought:
----------------------
- Whether oral medical treatment possible, instead of injection ? Because the later is quite expensive
- Chance of recovery justified on reports of blood test ?


Thanks in advance.


B.R.
satimis

Remark:
Because the data on this posting has been shifted unable to read it clearly. Please refer to the attach .pdf file for detail. TIA

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