Discussions By Condition: Liver conditions

Liver and Hepatitis B second opinion

Posted In: Liver conditions 3 Replies
  • Posted By: jkempf1
  • May 20, 2010
  • 03:59 AM

Is it a good idea to get a second opinion for my wife's Hepatitis B. She's suffering right now from jaundice; nausea, vomiting, lack of appetite, and is very weak for a few weeks now. Today we were told that the biopsy showed some collapsing of the liver. We were told that if the Hepatitis B medicine doesn't work or the liver can not rejuvinate itself we will be getting a transplant. Another problem is that she had a bile duct injury years ago that was repaired but I wonder if that could be causing problems as well as the Hep B?:mad:

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  • Ask her doc if it would be OK for her to try PPC (polyenylphosphatidylcholine) brand names "PhosChol" and HepatoPro; and perhaps some SAM-e.Research shows patients on PPC while on their IFN treatment did much better than those without it. ---------------------------------PPC in hepatitisPPC has been found to decrease serum aminotransferases in experimental hepatitis. In 1998, Niederau et al. conducted a multi-center randomized, placebo-controlled clinical study evaluating the effects of PPC in combination with interferon alpha (IFN) in patients suffering from Hepatitis B and C. IFN is the standard treatment for these diseases, however only 50% of patients with Hepatitis B and 20-30% of patients with Hepatitis C respond to this antiviral drug with long-term normalization of serum aminotransferases. Among patients with hepatitis C that do respond to IFN while under treatment, there is at least a 50% relapse rate. Evidently there is a need for more effective treatment.In this study 176 patients completed the protocol. All patients were given the same amount of interferon during the 24-week test period. In addition patients were randomly assigned to receive either 1.8 grams per day of PPC or placebo for the same 24 weeks. A biochemical response to therapy was defined as minimum 50% reduction of ALT compared to pre-treatment values.The results show that PPC increased the response rate to IFN in chronic viral hepatitis C (71% versus 51 % in the placebo group). Prolonged PPC therapy given to responders 24 weeks beyond the cessation of interferon therapy tended to increase the rate of sustained responses in patients with hepatitis C (41% versus 15%). Hepatitis B patients, however, did not have an improved biochemical response to interferon from PPC. The reason why PPC showed beneficial effect in hepatitis C and not in hepatitis B is not clear and will be further investigated.This study suggests that PPC can be a valuable adjunct to IFN treatment of Hepatitis C as well as be of beneficial use after cessation of IFN therapy in order to increase the chance of sustained response to therapy.-----------------------------------Good Luck and GodSpeed to you both
    synesthesia 87 Replies Flag this Response
  • Thank you and I will relay to the doctor.:oAsk her doc if it would be OK for her to try PPC (polyenylphosphatidylcholine) brand names "PhosChol" and HepatoPro; and perhaps some SAM-e.Research shows patients on PPC while on their IFN treatment did much better than those without it. ---------------------------------PPC in hepatitisPPC has been found to decrease serum aminotransferases in experimental hepatitis. In 1998, Niederau et al. conducted a multi-center randomized, placebo-controlled clinical study evaluating the effects of PPC in combination with interferon alpha (IFN) in patients suffering from Hepatitis B and C. IFN is the standard treatment for these diseases, however only 50% of patients with Hepatitis B and 20-30% of patients with Hepatitis C respond to this antiviral drug with long-term normalization of serum aminotransferases. Among patients with hepatitis C that do respond to IFN while under treatment, there is at least a 50% relapse rate. Evidently there is a need for more effective treatment.In this study 176 patients completed the protocol. All patients were given the same amount of interferon during the 24-week test period. In addition patients were randomly assigned to receive either 1.8 grams per day of PPC or placebo for the same 24 weeks. A biochemical response to therapy was defined as minimum 50% reduction of ALT compared to pre-treatment values.The results show that PPC increased the response rate to IFN in chronic viral hepatitis C (71% versus 51 % in the placebo group). Prolonged PPC therapy given to responders 24 weeks beyond the cessation of interferon therapy tended to increase the rate of sustained responses in patients with hepatitis C (41% versus 15%). Hepatitis B patients, however, did not have an improved biochemical response to interferon from PPC. The reason why PPC showed beneficial effect in hepatitis C and not in hepatitis B is not clear and will be further investigated.This study suggests that PPC can be a valuable adjunct to IFN treatment of Hepatitis C as well as be of beneficial use after cessation of IFN therapy in order to increase the chance of sustained response to therapy.-----------------------------------Good Luck and GodSpeed to you both
    jkempf1 1 Replies Flag this Response
  • When it comes to Hepatitis B, it can be much more easily transmitted than HIV. Hep B can be transmitted sexually or by coming in contact with someone's blood. You can become infected by sharing needles, razors, or toothbrushes. If you work in an occupation where you are at risk for Hep B, you should get a vaccine to prevent infection or use some kind of protection. For example, prison guards should take vaccines to prevent infections. Dentists and dental assistants should always wear gloves and goggles when dealing with patients.
    Anonymous 42789 Replies Flag this Response
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