Nephrotic Syndrome refers to a group of symptoms which is associated with increased permeability of filtration membrane and decreased glomerular filtration rate. These symptoms include large amount of proteinuria, serious welling, hypoproteinemia and hyperlipidaemia. Among these symptoms, only swelling is visible. Therefore, after people receive Stem Cell Transplant, by observing the severity of swelling, people with Nephrotic Syndrome can judge whether the treatment is effective.
Swelling appearing among people with Nephrotic Syndrome has a direct relationship with the severity of hypoproteinemia and that is to say the more severe the hypoproteinemia is the severity the swelling is. According to this theory, if we want to relieve swelling effectively, then we must repair the damaged glomerular filtration membrane so as to stop protein from being leaked out. Glomerulus is composed of different functional cells and that is to say repairing glomerular filtration membrane means treating damaged renal intrinsic cells. Stem cells have strong differentiation ability, so with the specific nutrient solution, we can help these cells differentiated into functional cells needed by us to replace necrotic renal cells. As to the damaged renal intrinsic cells, be aimed at activating them, stem cells can excrete trophic factors to stimulate them so as to they can play their function again. As filtration membrane is repaired, protein stops being leaked from our kidneys and leading to the remission of hypoproteinemia. Since hypoproteinemia is relieved, then swelling is relieved as well.