Discussions By Condition: Immune conditions

Son not showing immunity to shots

Posted In: Immune conditions 2 Replies
  • Posted By: laynak
  • February 1, 2007
  • 03:48 PM

My son had some blood work done because he keeps a snotty nose and sinus infection. His blood work came back that he doesn't show any immunity to having the DTAP shot, he is 3 and has 4 doses of this shot. On the Prevnar he shows immunity to 3 out of the 7 sub categories- Any ideas as to what causes this? His red, white and all of other blood work was good. HELP, I am scared to death.

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  • this sounds very familar. i'm 32 and recently found to have a condition called common variable immunodeficiency. when i was younger, and even today, i constanty had sinus infections, bronchitis, etc. i recently had bloodwork done and the doctors found my IGa levels to be virtually nonexistant. i too, have no immunity for measles, mumps, tetanus, etc even though i was immunized for them. PLEASE have a doctor test your son for COMMON VARIABLE IMMUNODEFICIENCY. i had to go to a large university hospital to get a diagnosis. the doctor treating it is a immunologist. good luck! if you'd like to e-mail me feel free. sunflower21@netzero.netkaren
    karen2 7 Replies
    • February 1, 2007
    • 07:49 PM
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  • Hello! I know how you feel. My son is 4 now and he was has Slective antibody Deficiency. My little one fought for 2 years of his life with chronic infection, pneumonia and ear infections. Please don’t let this go… It only gets worse. I demanded for my Peds. To refer me to a immunologist at Rainbows and Babies in Cleveland. He is currently being treated with Bactrium as a preventive, but it doesn't protect them from Strep. We are in the early stages, meaning seeing them every 3 months and conducting extensive blood work. I have suggested to his doctor that I would like to be tested also for genetic testing. The road is hard and all you can do is research this as much as possible. Don’t give up but talk to your doctor and keep a log of when your child gets sick and obtain copies of his or hers medical records and take them in with you when you go for a consultation. This way it gives them a better guide help your child and yourself. Attached below is a artical I stumbled apon. I will keep you and your child in my thoughts.....Good Luck...By: Selective Antibody Deficiency: Over the last few years we have observed many patients with severe recurrent infections including ear infections, sinusitis, bronchitis, meningitis and pneumonias. These patients also need multiple antibiotic treatments, surgical interventions such as sinus surgeries and suffer from asthma and decreased pulmonary functions.When Immunoglobulins levels were measured, these patients were noted to have a normal IgG, IgM and IgA. But when we measure certain specific antibodies to different organisms such Streptococcus pneumonia, Haemophilus influenza or others they may be abnormally low (unprotective). Since we are able to measure some of those specific antibody tilers, we are now able to understand these deficiencies more, and can identify some of those patients who have a normal total IgG level but are missing some specific antibodies.Because some of those antibodies are very important to fight some specific infections, such as Streptococcus pneumonia or Haemophilus influenza, patients who lack them may suffer from recurrent infections with those organisms. In this deficiency, compared to the first two, we are not missing millions of antibodies, just may be few thousands or so of the important ones.Unfortunately, because of the wide variety of antibodies our immune system makes, and our still limited testing abilities, we are not yet able to identify every selective antibody deficiency that exists, so we may still see patients with recurrent infections who are not able to make certain antibodies that are beyond our testing abilities. I believe that some patients start with Selective Antibody Deficiency after losing few specific antibodies then over time lose more and more antibodies and eventually progress to a full blown Common Variable Immune Deficiency (CVID). I have described two cases that were presented at 18th Annual meeting of the National Arab American Medical Association in June 2001, and another abstract was presented at the American Academy of Allergy, Asthma and Immunology last year. Again, when these patients continue to suffer from severe recurrent infections, complications, and poor quality of life, IVIG replacement therapy is definitely indicated to help them replace those antibodies.Enclosed also is another abstract that I presented last June about the efficacy of treatment with IVIG for those patients.Ten years ago we used to concentrate and pay more attention to the most severe immune deficiency diseases and ignore or not understand the mild forms of immune deficiency such as SAD. But now we have enough data and experience to help us diagnose those disorders early and treat them early to help reduce complications such as lung damage, pulmonary failure, meningitis, encephalitis and even death.
    Anonymous 42789 Replies
    • December 10, 2007
    • 02:17 AM
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