Discussions By Condition: Immune conditions

IGA Deficiency

Posted In: Immune conditions 31 Replies
  • Posted By: rdhosm
  • October 4, 2006
  • 00:37 PM

I was diagnosed several years ago with an IGA deficiency. As a result, I have reoccuring sinus infections on a monthly basis. I am never off some form of medication longer than two weeks. Currently, I have had ear pain for two weeks and it has gotten to the point that my doctor will ask me what I want him to prescribe. I have taken every medication available and my body has now built up a tolerance so nothing works anymore.
If any of you have experienced this problem, please let me know what you have done that works. I am not opposed to natural, organic or herbal meds if they will bring me some relief.
My primary care physician, ENT and allergist have all made the same conclusion. IGA defiency. Had the surgery, didn't work.

Thanks,

RDHOSM

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31 Replies:

  • hi i'm italian and i'm 20.i dicovered i had this deficiency after years of diseases and no diagnosis. my infectionts were primarly located in sinus and abdomen. also it is not clear whether i'm celiac or not (did u ever heard about the probability that the deficiency brings to celiac disease and at the same time makes the tests false-negative ?). Lately i got in a "tunnel" and too many symptoms (such as kidney pain, headache, nausea, anorexia, ) which suggest maybe an autoimmune disease. did you hear about the relation between these things?
    enricorialti 1 Replies
    • November 3, 2006
    • 02:52 PM
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  • Hi, yes I have also been told I have a low IgA recently. I have apparently HAD mononeucleosis (glandular fever we call it over here in Australia!) but not sure when, as I was sick so many times at the beginning of 2006 and throughout the year - mainly with throat things, and sinus infections (never actually went to the dr until late last 2006!). I have been really tired, etc. and no energy, and also just had another sinus infection and possibly tonsilitis (and today my throat is getting sore so I may be getting sick again). I am a very busy person so that probably just makes it more likely for me to get sick, but I never used to and I don't like it!What exactly does a low IgA mean??? Is it true that the tests can give a false negative if you have a low IgA? I am going to see a "General medicine" specialist about that and other problems at the end of this month but dont understand it. I have also been tested (endoscopies, blood tests, etc.) for celiac disease and crohn's disease (as this is in my family) and they were negative - but I feel there is still something going on in my body. I cant seem to get a straight answer to anything - I am also experiencing vertigo frequently and may have to have a head CT scan.Any information would be great and experiences from other people with similar problems. I have had just about every test under the sun. I have symptoms ranging from abdominal pain to nausea, lack of energy, feeling sick in the morning, recurrent infections, slow healing sores, mouth ulcers, etc.!!! I have also recently had something called "duodenitis" (which I think is like small ulcers in the first part of your small intestine) - discovered in the endoscopy.
    Anonymous 42789 Replies
    • January 8, 2007
    • 04:36 PM
    • 0
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  • hi.iga deficiency is pretty common, but in some cases (meybe yours) it can bring to recurrent infections of both upper ways ( lungs and so on ...) and intestines ( this could maybe explain some of your sintoms). There is no cure, actually, but it is not a real illness and you can manage it pretty well if you consult a doctor ( may a specialist of immunology). At the same time i would advice you to consider some other diseases that are common in people like us with no igA. Many of them can develop autoimmune diseases: it is my case. Unfortunately I have eventually found out the reason of my problems. i have sle (lupus), which is a pretty hard illness to deal with. But also the celiac morb is frequent. So take this into consideration, and then if all these tests are negative, focus on your iga deficiency, which u will probably easily manage with antibioticsgood luck
    Anonymous 42789 Replies
    • January 8, 2007
    • 06:30 PM
    • 0
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  • Hi again,Thanks for posting a reply! I didn't actually think this thing would work. Sorry to hear about your diagnosis. I have been tested for Celiac disease and it came up negative and the doctor also had a look at my intestines to see if he could see any evidence of it but could not. Is it still possible that I have it or could be developing it do you think? I know you're not a doctor!!! But may know more than me about it! I just keep looking at other disorders, and it seems to be a close match - I have most of the symptoms. Maybe I could just try a wheat-free diet and see how it works!Good luck with your treatment, etc.
    Anonymous 42789 Replies
    • January 9, 2007
    • 04:34 PM
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  • Hi I am a 29 year old female with iga ef. Let me tell y ait is a long road and you need to get to a allergist 4-real. I was diagnosed yesterday with fibormalgia. If you have any question I ahve been dealing with this for some time
    Anonymous 42789 Replies
    • January 11, 2007
    • 01:03 PM
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  • I have been tested for Celiac disease and it came up negative and the doctor also had a look at my intestines to see if he could see any evidence of it but could not. Is it still possible that I have it or could be developing it do you think? Its definately possible. It is a progressive condition and everyone has different symptoms, so you may not even have evidence of it in your intestines. Of course in that situation it can't be called Celiac disease, even if it is gluten triggered.They also don't have much research or testing methods on non-gluten food intolerences like corn, soy, milk protein (not the common lactose milk sugar intolerence), but there are people who got labeled or suspect Celiac because of symptoms and only found improvement by removing a different food from their diet.
    Azaral 152 Replies
    • January 11, 2007
    • 01:30 PM
    • 0
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  • Hello- I don't know if anyone has ever told you about C.F.I.D.S. or Chronic Immune Dysfunction Syndrome -?? I have been ill for years- Many auto-immune diseases seem to start one way- and seem to keep changing. So many mirror each other- it gets VERY frustrating. I used to be sick with sinus infections, resp. infections. on and on.... I still get infections actually they say that alot of them collonize- that you really can't totally kill them. Another thing is allergic reactions to meds. Fibromyalga is also sometimes confused with or it is given as a diagnosis when the Dr. doesn't have an answer. CFS or Chronic Fatigue Syndrome-and C.F.I.D.S. are one in the same it is called by another name in Canada- can't think of it now- has to do with the brain...anyway The name Chronic Fatigue- is true people who have it are tired- but is a different type of tired- I get so "Tired" of friends or others saying "Oh I have that. I get tired ,too!" It is like a brain fog- and the tired is all incompasing- not thr same tired that you'd get after working all day- it's so different. We are all hoping for a name change to CFIDS- since it is an immune system disorder. If I were you- I'd do a search-or google CFIDS as well as the other things I gave you. I have been on I.V. Gammaglobulin weekly for years- Drs.- & insurance co. don't like it because it is so expensive. I know mine is 5000.00 a week including the infusion center charges sometimes more. It boost my immune system- or should I say gives me one! I used to be sick ALL the time - I've been in the hospital more times than I could count-I still get sick- really sick---but the gamma really helps big time!- It is used for alot of other illnesses- they use it for the troops- but if your level is LOW I would definatly ask about it. It is usually given monthly -but I now that my Dr. felt- and I agree totally that it needs to be weekly- I have found that there s NO way that I can take it as fast as what the pharmacy labels it to be given- the others that get it have the same problem- I only get 10 grams I beleive- I also get premedicated with I.V benedryl to help me not have a reaction to the Gamma since I have problems with reactions- I spend about 5 hours a week at the infusion/oncology Dept. I have at different times when we take the kids on vacation gone 2 weeks and gotten it when I got home...and I always get sick... so there is no way I would be talked into trying 1 time a month! I started years ago on shots- but soon my Dr. changed it to weekly I.V. One of my Drs. ... my main one- is wonderful- alot of research is done in his office. Alot of Drs. don't understand or really know much about CFIDS/CFS I hope I have helped in some way. Keep the FAITH !!!
    givelifeadance 2 Replies
    • January 13, 2007
    • 00:52 AM
    • 0
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  • ...I forgot- I"ve been diagnosed with Celiac, Lupus, Mono-(it can re-activate), I can't even remember how many things I really believe that the Drs. get frustrated and try to come up with something...but, the problem is that the symptoms keep changing...it's all part of it-Oh, if you haven't been you should also be checked for Lyme Disease- often I have heard hard to diagnose- caused by ticks, mimics alot of the same symptoms... I think your help is going to be in I.V. Gamma. May want to Look up -Dr. Daniel Peterson Incline Village Nevada- Look up the whole name and town/state. He is my Doc. He's been on many 20/20's and 60 Minutes type shows. You might find out about a drug trial - as well as a Dr. where you live. Blessings-
    givelifeadance 2 Replies
    • January 13, 2007
    • 01:13 AM
    • 0
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  • If you have Celiac's, it can cause every other thing you listed, ESPECIALLY the fatique and brain fog and devastated immune system. Was that just a doctor's idea 'cuz your symptoms sounded that way, or was it backed by a blood test and/or colonoscopy? If its a lab result, you'd probably be better off just treating the food intolerence.I went from CFS, Mono, whole-body rash, 14 hours of sleep a day, constant brain fog, painful joints, every single infection knocking me down for 3 days, to being almost completely normally healthy. The problem is finding the sources of 'hidden' gluten. Citric acid, monosodium glutamate, broth, binder, 'natural flavors,' unspecified and food starch, etc. These are all 'maybes' depending on how they are prepared. A tiny bit and I'll be on my bed (and running back & forth from the bathroom) for 3 days. It takes literally months or years of 100% dietary compliance for your body to completely recover. The immune system booster probably isn't hurting you, but it sounds rather expensive and it won't treat the underlying cause :)Eating out is a nightmare, but being healthy is a dream come true. People don't seem to think a food intolerence can really cause so much trouble, but Celiac's is truly a killer. It doubles the mortality rate of untreated patients by causing cancer at an alarming rate and obliterating the immune system. And there is no drug to cure the cause, you really just have to watch every single ingredient you eat and ensure the utensils you use to cook with are completely clean (wooden spoons might never be clean again, protein can hide in the texture). And actually, a whole lot of pills and vitamins are made with gluten additives. That which is intended to cure, could be the root of the problem.
    Azaral 152 Replies
    • January 13, 2007
    • 04:45 PM
    • 0
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  • Hi,Thanks for the info. I know they say not to commence a "gluten-free" diet until a diagnosis has been made, but do you think, if I have been tested, and the dr doesnt seem to listen to what i say about celiac disease, there would be any harm?? If I feel better afterwards, I'll stay on the diet, if not, then there's no problem there!Also, do you know of anyone who has done the questionnaire at http://www.diagnose-me.com ??? I did it and it was OVER 1000 questions! The only reason I completed it was because they asked everything under the sun and it was very relevant. I thought it was free (or so they said) until the end of the questionnaire when it asked how I'd like to pay for the report...! I am thinking of getting it just because I spent so long on it and they were great questions, but does anyone know if it is good or not? (It will cost US$47).ThanksChelsea
    Anonymous 42789 Replies
    • January 14, 2007
    • 06:41 AM
    • 0
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  • Chelsea,It is posible to be gluten sensitive and not necessarily allergic to gluten. People with Celiac disease are actually allergic to gluten and it ellicits an auto-immune response when it is eaten, causing intestinal damage. On the other hand, you can be sensitive to gluten, and have adverse reactions when you eat it, but not cause damage to your intestines. I have been going to a dietitian and a gastroenterologist and had all sorts of tests run from blood work to scans, to endoscopies... the final conclusion I was given was that I am gluten and lactose intollerant/sensitive, but not allergic to them. I would say pick a diet that makes you feel better. Going gluten-free is difficult and frustrating, but after all is said and done, I no longer have abdominal pain, bloating, and all the other negative reactions. Good luck!
    Anonymous 42789 Replies
    • February 21, 2007
    • 02:31 PM
    • 0
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  • Hi all i have cvid (common variable immunodeficiency) it means i dont make white blood cells that fight infection my first symptoms 20 years ago were mouth ulcers, a bout of shingles, ulcerated bowel (how painful is that) then bruising diagnosed with thrombocytopenia (low platelet count) then numerous infections of chest throat sinuses ears to name but a few, then they diagnosed cvid so i now have weekly infusions into my stomach for about two hours, this replaces intra veinous 3 weekly infusions, so for the lady of the original post your symptoms sound very like mine you may need to see an immunologist and you could look at the PIA website (primary immunodeficiency assosiation) they have a list of signs and symptoms and a discussion forum hope this is of some help to you good luck:) Diane
    Diane Sistern 29 Replies
    • February 21, 2007
    • 04:43 PM
    • 0
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  • Chelsea,It is posible to be gluten sensitive and not necessarily allergic to gluten. People with Celiac disease are actually allergic to gluten and it ellicits an auto-immune response when it is eaten, causing intestinal damage. On the other hand, you can be sensitive to gluten, and have adverse reactions when you eat it, but not cause damage to your intestines. I have been going to a dietitian and a gastroenterologist and had all sorts of tests run from blood work to scans, to endoscopies... the final conclusion I was given was that I am gluten and lactose intollerant/sensitive, but not allergic to them. Iwould say pick a diet that makes you feel better. Going gluten-free is difficult and frustrating, but after all is said and done, I no longer have abdominal pain, bloating, and all the other negative reactions. Good luck! I'm not happy with the current definitions of allergy and sensitivity used in medical science today. A "normal" allergy is catalyzed by Immunoglobulin E (IgE) and all the various scratch tests they do are looking for this IgE specific immune reaction. Celiac patients usually are "not allergic" to gluten because they will usually be negative on the IgE tests (occasionally though it is possible to be a Celiac with a traditional wheat allergy as well -but its a very rare cross-over rate because "truly" allergic people are likely to realize this early on and limit wheat consumption). The Celiac-specific tests look for an immunological response triggered by Immunoglobulin G (IgG) and A (IgA) . Basically, since it isn't IgE they don't want to call it an allergy because it breaks the mold of traditional allergies. IgG reactions begin much later after consumption and last much longer than IgE reactions. But sensitive/intolerent patients and Celiac patients all have the same type of IgG immune response (what varies is the severity of the reaction). What actually differentiates Celiac from a gluten sensitivity is simply the amount of intestinal damage done at the time tests are conducted. Many patients have IgG and IgA levels in the extremes of the "normal" range or even outside the normal range but with a normal biopsy; a smart doctor will realize the issue before it progresses into total villous atrophy even though with a negative biopsy it is technically impossible to give a "gold-standard" Celiac diagnosis. It seems like if you abandoned your diet for many years, you will be at high risk of developing the complications of gluten sensitivity that leads to the intestinal symptoms that define Celiac. Ideally, no one would ever become Celiac because the blood test that defines IgG immune response to gluten can be positive many years before the intestines are damaged enough to show a positive Celiac' diagnosis. Also, be aware that in cases of gluten intolerance, more than half of patients are able to tolerate milk one year after a gluten-free diet (the healed intestines process difficult food more effectively.)
    Azaral 152 Replies
    • February 21, 2007
    • 07:19 PM
    • 0
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  • Sinus and ear infections bascially describe my childhood. I know when I was younger I was on anti-biotics all the time and I eventually grew out of having infections so often. Now when I get a cold, I use a Netti pot. I think it's about $15 for a cheap plastic pot that you put a little bit of saline (salt powder that comes with it but don't put much in) and warm water. Next make sure you're standing upright but maybe leaning forward a bit over a sink. Then start breathing out your mough and put the spout to one nostril and tip it so that the water goes in. The warm water/saline will travel up your nostril, through your sinus, and our the other nostril. During this keep breathing through your mouth. If you try to breathe through your nose you'll inhale the warm water. If you use the Netti pot too often you can make your nose bleed a little bit. Sometimes there is a very long delay for the water from the time it starts travelling up your nostril to the time it comes out the other side. Make sure to have a lot of tissues around after since you'll need to blow your nose, but don't blow your nose too hard because doing that will irritate the lining of the nose. This works great for me and I strongly reccommend it.
    xyz2814 4 Replies
    • October 30, 2007
    • 09:07 AM
    • 0
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  • I too am suffering fromGi infections which is very frequents and forces me to take anti biotic. In last 6 months I had had 2 infections of pnumonia and my doctors are also worried that it could be fatal.Can any body suggest me a way out. its an SOS!!
    Anonymous 42789 Replies Flag this Response
  • Check out sinusinfectiondiscovery.com. I have not tried it but it is a natural plant extract and sounds hopeful. BuddyGinger
    Anonymous 42789 Replies
    • November 19, 2008
    • 00:11 AM
    • 0
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  • Hi All,I too had a miserable childhood, full of allergies, sinus and ear infections. My over-all gammaglobulin tested low, so once a month I got a 50 cc syringe full of clear thick gammaglobulin fluid delivered over a few minutes with a large guage needle. That lasted for 4 years until I reached puberty. It actually helped, but I had to have my tonsils removed twice because of chronic tonsilitis - yes, tonsil tags do grow back! The shots actually helped me, but that was a long time ago, and Dr's don't do that anymore.In 1992 and 1993 I had three major sinus surgeries to remove and rebuild everything, and also got J tubes in my ears for the scarring from numerous infections. Afterwards, I had a chronic major sinus infection that would not clear up with numerous antibiotics, and my Doctor was actually considering hooking me up to a portable venous pump to deliver antibiotics, that I would wear 24/7. I didn't feel that would work, and asked him if there was any blood tests that might shed some light on the situation. He thought about it for a while, and said that there was a new test out for four gammaglobulin subsets, but the test was awfully expensive and had to be sent out of state, and usually came back negative for any problems. At that point I didn't care, and requested the test. Sure enough, the two subsets directly related to the sinuses came back as mostly non-existent (IgA & IgB?-can't remember). My Doctor was flabbergasted, and had to refer me to an immunologist in another state. I received a very thorough exam to rule out any other problems, and the immunologist gave me two choices:1. Get an expensive gammaglobulin IV once a month; a 240 mile round trip for me. It was a bargain at only $4,000 at the time, but the drawback is that the transfusion contains live blood products, and you can pick up some other disease. Even now, I don't think blood can be completely screened for everything, so there is always a health risk in receiving blood, especially on a regular basis.2. Go to my local Health Department, and get ALL of the childhood shots again, plus pneumonia shot, and be vigilant about getting a yearly flu shot. This stimulates the immune system and causes the T cells to top out. The high T cells counters the low subsets, and immunity returns.Well, this one was a no-brainer! I went to the health department, and they were happy to help. I had discontinued the antibiotics before I had the blood tests, and my problems cleared within a week. Later that year I also had all of the silver amalgam fillings removed from my mouth, and replaced with white fillings that were non-reactive with my blood. Did you know that dentists are required to treat old and new silver fillings as hazardous waste by the EPA??Anyway, I've been healthy ever since, except for osteoarthritis caused by excessive backpacking. And I'd do the backpacking all over again too, if I could!
    Anonymous 42789 Replies
    • January 3, 2009
    • 10:20 PM
    • 0
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  • If you have Celiac's, it can cause every other thing you listed, ESPECIALLY the fatique and brain fog and devastated immune system. Was that just a doctor's idea 'cuz your symptoms sounded that way, or was it backed by a blood test and/or colonoscopy? If its a lab result, you'd probably be better off just treating the food intolerence.I went from CFS, Mono, whole-body rash, 14 hours of sleep a day, constant brain fog, painful joints, every single infection knocking me down for 3 days, to being almost completely normally healthy. The problem is finding the sources of 'hidden' gluten. Citric acid, monosodium glutamate, broth, binder, 'natural flavors,' unspecified and food starch, etc. These are all 'maybes' depending on how they are prepared. A tiny bit and I'll be on my bed (and running back & forth from the bathroom) for 3 days. It takes literally months or years of 100% dietary compliance for your body to completely recover. The immune system booster probably isn't hurting you, but it sounds rather expensive and it won't treat the underlying cause :)Eating out is a nightmare, but being healthy is a dream come true. People don't seem to think a food intolerence can really cause so much trouble, but Celiac's is truly a killer. It doubles the mortality rate of untreated patients by causing cancer at an alarming rate and obliterating the immune system. And there is no drug to cure the cause, you really just have to watch every single ingredient you eat and ensure the utensils you use to cook with are completely clean (wooden spoons might never be clean again, protein can hide in the texture). And actually, a whole lot of pills and vitamins are made with gluten additives. That which is intended to cure, could be the root of the problem.Marshallprotocol.com is mainstream medicine non-profit site with FDA approved combo, low pulsed drugs used to weaken L-form bacteria so your immune system can rebuild in 2-4 yrs. Human Health Services supports the MP consisting of 25 chronic diseases. It consisted of 500 people (250 doctors, RN's, biologist, retired FDA,) in 2002. People who are desperatly ill join; because it is a cure, not just a pill or proceedure at the expense of your life. If your chronically ill, the next step is death! All the sensitivities will go away and you will feel 20 years younger. Bacterial Biofilms cause Obesity, malnurishment, and neurodemilation. Psyco drug damage brain, anti viral/fungal mess up metabolism, prednisone/cortisol, antibiotic chemotherapy lowers immune system. Take care of the 90% out of sync bacteria good and bad, and the immune system will take care of viral, fungal, bacteria in about a year when the body can rebuild enzymes(proteins) that are suppose to fight bacteria.
    Anonymous 42789 Replies Flag this Response
  • Marshallprotocol.com is a mainstream medicine non-profit site with FDA approved combo, low pulsed antibiotics used to weaken L-form bacteria so your immune system can rebuild in 2-4 yrs. Human Health Services supports the MP site consisting of 25 chronic diseases. It started with 500 people (250 doctors, RN's, biologists, retired FDA) in 2002. People who are despirately ill join; because it is a cure, not just a pill or procedure at the expense of your life. If you're chronically ill, the next step is death! All the sensitivities will go away and you will feel 20 years younger. Bacterial biofilms cause obesity, malnutrition, and neurodemialonation. Phsycotic drugs damage brain, anti viral/fungals mess up metabolism. Prednisone/cortisol, antibiotic chemotherapy lowers the immune system. Ninety % of our body is made up of good and bad bacteria if they are weakened the immune system will rebuild itself in a year with enzymes (protiens) which will once again fight the viral, fungal, bacteria; which will prevent inflammation that leads to cancer.Debz
    Anonymous 42789 Replies Flag this Response
  • I have a low level of IgAs and SIgAs although not low enough to be classed as a deficiency. I was also recently diagnosed with the autoimmune disease Sjogren's Syndrome. I haven't read all of the posts here, but didn't see at a quick glance that Sjogren's was mentioned. Sjogren's attacks the secretory glands of the eyes, nose and mouth as well as other secretions and can have systemic complications. I have bad sinuses due to the dryness and inflammation and sometimes find relief with a humidifier and herbal remedies. Sjogren's can be a difficult disease to diagnose and many ME sufferers may actually have undiagnosed Sjogren's. Sjogren's syndrome hasn't received a lot of attention medically because it is such a difficult disease to diagnose but that is now changing. I just thought it might be worthwhile mentioning Sjogren's in case this may be a contributing factor.
    Anonymous 42789 Replies Flag this Response
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