Discussions By Condition: I cannot get a diagnosis.

Too many presriptions or wrong prescriptions?

Posted In: I cannot get a diagnosis. 3 Replies
  • Posted By: truckee
  • February 19, 2008
  • 07:19 PM

Hi - I'm looking for some objective opinions. I'll try and keep it short. Battling depression for about 10 years. Tried a variety of anti-depressant. Then diagnosed soft bi-polar. Use a variety of meds. Two different therapist strongly disagreed with Psychiatrist on that. Then diagnosed as ADD (no hyperactivity).

I am on Cymbalta (60mg), Lamictal (200mg), Concerta(72mg) and Provigil(400mg). It's been about a year for the first three, with doses going up over time. Provigil was added this past October due to excruciating fatigue. But not much effect.

I can barely wake up to two audible alarms & two lights on timers. One is a powerful light box. I can sleep 12 hours if unabated. Don't drink anymore, smoke anymore, not overweight, history of heavy endurance sports. Fatigue, extreme sleepiness, aches getting worse. I gave up on active social life because its too tiring and sick of canceling due to severe need to go home and put my feet up. Thankfully I can take the money from entertainment, travel & sports to get talk therapy, cleaning, garden, organizing, bill pay & laundry services. Can't fend for myself seems like. Such craziness. I laugh at least.

Also, I just got a battery of allergy tests. Waiting for results. Liver asgot (?) just tested high. BP & cholesterol is up again. Had sleep apnea surgery 18 months ago and going back this week for another overnight sleep study. Also, got fitted for hearing aids due to a lifetime of water sports (thus ear infections) catching up with me at age 40.

Nice job, nice home, money is fine, have pets. But, brother with MS, sister with severe depression/alcohol issues and her son, my nephew died 4 months ago of Leukemia at 22 y.o., Mom passed with cancer 14 years ago. Dad had, but conquered, prostate cancer about 8 years ago.

OK, not too short here! But trying to think of all the details that may paint a picture other than the diagnosis of Major Chronic Depression & ADD. Meds, caffeine and tons of sleep just aren't doing it still!

Ideas?

What gives?

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3 Replies:

  • You may want to consider getting your thyroid antibodies checked. I was diagnosed with depression for years, but it never lifted on meds. As it turns out, I have a rare complication of autoimmune thyroiditis called Hashimoto's Encephalopathy. My thyroid hormones have always been okay. It was diagnosed only by checking thyroid antibodies...There have been some studies showing that people with "depression" unresponsive to meds may actually have elevated thyroid antibodies. Your sleep apnea, intense fatigue, elevated cholesterol, ADD symptoms, etc may also be consistent.Of course, these symptoms can be vague and from a lot of different things, so this may not apply. I just thought I'd throw it out there since it took me 8 years to get diagnosed and the whole time I was reassured that my thyroid gland was okay.Best Wishes.
    Anonymous 42789 Replies
    • February 20, 2008
    • 02:24 AM
    • 0
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  • If your doses keep increasing and you keep getting worse... sometimes that can be a red flag for something going on that the meds only mask for a little while. I think you could be on too many meds or may need to look for new ones; or a drug vacation may be due. But it is very possible you have another illness going on the meds can only mask for awhile.... (I think this is the most probable explanation myself). That your liver enzymes; BP and cholesterol have went up indicate a possible liver problem or an illness such as acute intermittent porphyria that affects the liver... could be acquired or genetic form of porphyria (porphyria and MS are similar diseases, many porphyria patients also have been diagnosed with MS ) triggered by one or more of your drugs. Perhaps your brothers MS is tied into a porphyria disease (a metabolic disease of the liver and blood marrow also). Even the child leukemia could be related to porphyria. Other problems that could have caused the changes include infections, diabetes and other metabolic/hormonal disorders. I would look for a liver specialist to check the liver out; and look into a drug vacation to see if stopping the meds brings the enzyme level back down (the elevated enzyme level indicates liver inflammation). Do you have any digestive complaints?What were the allergy tests for? Many psych patients have porphyria and porphyria causes many psych complaints, sadly... many porphyria patients commit suicide because of the pain and years without adequate medical attention due to difficulty in finding the diagnosis and finding a dr who knows how to treat porphyria. I think it is worth checking out porphyria.... as one of many possible causes... get the liver checked out by a dr who knows metabolic diseases and liver problems. ASAP, as your meds are possible triggers for porphryia. You need to avoid alcohol and find porphyria safe meds (would not hurt to do this if done carefully working with a dr who understands porphyria and other liver problems). I will dig you up some links. Hi - I'm looking for some objective opinions. I'll try and keep it short. Battling depression for about 10 years. Tried a variety of anti-depressant. Then diagnosed soft bi-polar. Use a variety of meds. Two different therapist strongly disagreed with Psychiatrist on that. Then diagnosed as ADD (no hyperactivity). I am on Cymbalta (60mg), Lamictal (200mg), Concerta(72mg) and Provigil(400mg). It's been about a year for the first three, with doses going up over time. Provigil was added this past October due to excruciating fatigue. But not much effect. I can barely wake up to two audible alarms & two lights on timers. One is a powerful light box. I can sleep 12 hours if unabated. Don't drink anymore, smoke anymore, not overweight, history of heavy endurance sports. Fatigue, extreme sleepiness, aches getting worse. I gave up on active social life because its too tiring and sick of canceling due to severe need to go home and put my feet up. Thankfully I can take the money from entertainment, travel & sports to get talk therapy, cleaning, garden, organizing, bill pay & laundry services. Can't fend for myself seems like. Such craziness. I laugh at least. Also, I just got a battery of allergy tests. Waiting for Had sleep apnea surgery 18 months ago and going back this week for another overnight sleep study. Also, got fitted for hearing aids due to a lifetime of water sports (thus ear infections) catching up with me at age 40. Nice job, nice home, money is fine, have pets. But, brother with MS, sister with severe depression/alcohol issues and her son, my nephew died 4 months ago of Leukemia at 22 y.o., Mom passed with cancer 14 years ago. Dad had, but conquered, prostate cancer about 8 years ago. OK, not too short here! But trying to think of all the details that may paint a picture other than the diagnosis of Major Chronic Depression & ADD. Meds, caffeine and tons of sleep just aren't doing it still! Ideas? What gives?
    TaylorDeelwithit 382 Replies
    • February 20, 2008
    • 06:59 PM
    • 0
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  • Check out this post I sent to another member about porphyria... http://forums.wrongdiagnosis.com/showpost.php?p=79061&postcount=5Some helpful links to get you started.... to looking into this. With the amount of meds you are on and the time you have been taking them.... the meds have to be ruled out as causes of the liver inflamation and other symptoms... Perhaps you should look into NASH also... others mention it on the same thread. Hi - I'm looking for some objective opinions. I'll try and keep it short. Battling depression for about 10 years. Tried a variety of anti-depressant. Then diagnosed soft bi-polar. Use a variety of meds. Two different therapist strongly disagreed with Psychiatrist on that. Then diagnosed as ADD (no hyperactivity). I am on Cymbalta (60mg), Lamictal (200mg), Concerta(72mg) and Provigil(400mg). It's been about a year for the first three, with doses going up over time. Provigil was added this past October due to excruciating fatigue. But not much effect. I can barely wake up to two audible alarms & two lights on timers. One is a powerful light box. I can sleep 12 hours if unabated. Don't drink anymore, smoke anymore, not overweight, history of heavy endurance sports. Fatigue, extreme sleepiness, aches getting worse. I gave up on active social life because its too tiring and sick of canceling due to severe need to go home and put my feet up.
    TaylorDeelwithit 382 Replies
    • February 20, 2008
    • 07:08 PM
    • 0
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