Discussions By Condition: I cannot get a diagnosis.

Secondary Hypertension?

Posted In: I cannot get a diagnosis. 3 Replies
  • Posted By: Anonymous
  • February 15, 2007
  • 11:51 AM

I was recently (middle last year) diagnosed with hypertension (140~160/90~110). Was a regular blood donor for 3 years, so BP was a sudden one. It is pretty stubborn. Am currently on Norvasc (Amlodipine) 10mg, and Diovan (Valsartan) 160 mg.

Doctors are sure it isnt essential hypertension because I dont have family history, my BMI is 21.0 and I was 20 when diagnosed (last year). But nobody knows what is wrong.

I tested negative for Pheochromocytoma, Conn's, Cushings, Heart Problems, Renal Artery Stenosis, Kidney problems and Thyroid function is normal.
My aldosterone reading is normal although my Renin levels are high, at 17.0 (Range is 0.2-2.8).

Now I have pretty bad Tremors, mostly concentrated on my left side. Was recently started on Inderal (Propranolol) 40mg, which is also a Beta-Blocker. So technically, am on 3 BP medications, but my BP can still go shooting.

I also seem to be tired all the time. And my left leg keeps getting pins-and-needles, for no apparent reason.

One doctor wants me tested for Porphyria. But I have no severe abdominal pain.

Does anyone have any advice? Can it be secondary hypertension? Any similar experience? I'm tired of seeing doctors and them sending me for horrible tests.

Thanks a million!

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3 Replies:

  • I had Conn's disease, treated with surgery and now normotensiveMy potassium levels were low for over two years, that caused the "pins and needles" you are describing in my forearms and my legs. I also had severe cramping of my hands and feet with any activity and incredible fatigue How were you evaluated for stenosis? Have you been seen by someone who specializes in hypertension, either a nephrologist or an endocrinologist. I was misdiagnosed as essential hypertension for years because my father was hypertensive. No testing was done for 13 years, every med was tried and diet and exercise didn't lower my BP. It kept climbing to dangerous levels despite treatment. That forced testing and the adrenal adenoma producing excess aldosterone was found The aldosterone/renin ration is what is necessary to determine hyperaldosteronism. Ideally you shouldn't be on meds when this is done. Blood pressure medications can alter results of this testing
    rck213 3 Replies
    • February 15, 2007
    • 06:50 PM
    • 0
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  • Dear rck213, I am under a professor in Endocrinology. She along, with about 6 others, are sure I don't have essential hypertension. They also seem to agree that it is possible my hypertension was caught so early on that diagnostic tests are not showing anything. MRI is all clear, although the Prof thinks my adrenal gland looks a little bulky. I was tested for Conn's. My aldosterone/renin ratio was about 19.8! So it's definitley not Conn's. Plus, my potassium and sodium levels have been normal despite repeated testing. Was tested for renal artery stenosis when my renin levels came back so high, wiht a Doppler Ultrasound (Duplex)...Negative! I'm just so sick of having to go to the hospital and be subjected to all kinds of tests. I feel like some hypocondriac:(. I just wonder if I should continue testing. Thanks for being so prompt with your reply. I sure appreciate it:)!
    Anonymous 42789 Replies
    • February 16, 2007
    • 02:36 AM
    • 0
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  • Again, if you were tested while on medication for hypertension the results may be scewed. Also an ultrasound isn't the best way to confirm renal stenosis.I so happened to also have a renal stenosis caused by Fibromuscular Dysplasia that wasn't seen with the ultrasound but a Renal MRA then a Renal CT angiogram showed it clearly. Research all you can online. The Mayo Clinic site has info on secondary hypertension. Primary Aldosteronism develops over time, it can be from either a single tumor or multinodular adrenals. Have you been put on Sprironolactone or Inspra? You'll understand why I ask after you do some research.
    rck213 3 Replies
    • February 17, 2007
    • 08:09 PM
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