Discussions By Condition: I cannot get a diagnosis.

Possibly MS?

Posted In: I cannot get a diagnosis. 4 Replies
  • Posted By: Ovationlady
  • February 26, 2009
  • 04:56 PM

My MRI showed many spots in the white matter and signs of demyelination. I have many symptoms of MS, but my spinal tap results did not show any of the "bands" associated with MS. Is it possible to still MS without a positive spinal tap? Thanks.

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  • Okay, I've read your inquiry. Lumbar puncture findings in MS include a normal opening cerebrospinal fluid (CSF) pressure, fewer than 20 mononuclear cells, a normal or slightly elevated protein level, a negative CSF VDRL test, and negative tests for bacteria and fungi. These findings rule out many infections that can mimic acute MS. The myelin basic protein level is typically elevated during acute exacerbations of MS. The Oligoclonal bands (OCBs) are found in a high ratio of patients in whom definite MS is eventually diagnosed. OCBs are also seen in patients with other inflammatory diseases of the nervous system, including viral, bacterial, and fungal infections and CNS vasculitis. In addition, they can be found in patients with cancers of the nervous system, CNS syphilis, other demyelinating diseases, and some parasitic diseases. The unique pattern seen in MS patients does not change over time. It is important to perform simultaneous measurement of OCBs in the blood. The CSF IgG index gives invaluable information about abnormal immunoglobulin synthesis in the brain. An abnormal index can be found in about 90% of patients with MS, but it is not disease specific and may also occur in more than 50% of patients with inflammatory and infectious disease of the CSF. In sum, you can definitely have MS with a negative lumbar puncture for OCBs. It is the characteristics of the patterns observed in the LP that, together with other diagnostic criteria, support a diagnosis of MS. Best regards, J Cottle, MD
    JCottleMD 580 Replies
    • February 27, 2009
    • 00:54 AM
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  • Yes it is possible to have MS. Try to get on a regimen to alleviate or reduce symptoms.
    Carrlexzi 36 Replies
    • February 27, 2009
    • 02:27 AM
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  • Thank you for responding. As a matter of fact, my protein level was elevated to 8.4 and my Vitamin D level is 14.2. This was noted on my chart. Should I be concerned? Does this have to do with MS? Thank you.
    Ovationlady 9 Replies
    • February 27, 2009
    • 02:16 PM
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  • Hi I think before accepting a MS diagnosis for the rest of your life, you should really investigate lyme disease. Chronic lyme disease. I was diagnosed with ms, as other diseases, and I finally have lyme, chronic lyme. I am going better and I'll get rid of that. Maby you are not aware of lyme disease except that you might have a bulls eye, please note that 50% do not remember it as it does not appear automatically. If you were tested for lyme, note that the standard test are being contested even by politicians. right now because they are not accurate. As the standard treatement. Read the symptoms of chronic lyme, go on lymenet, look on youtube, make your own research but please take it in possibility. You don't want to lose your life with a wrong diagnosis. I almost did. Seek a LLMD. (lymenet)
    Fannou 111 Replies
    • February 27, 2009
    • 08:07 PM
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