Discussions By Condition: I cannot get a diagnosis.

please help severe urticaria

Posted In: I cannot get a diagnosis. 1 Replies
  • Posted By: Anonymous
  • March 14, 2008
  • 07:34 PM

4 months ago i came out in severe urticaria all over my body very very itchy and sore with face and hand swelling, I was commenced on TElfast (antihistamine) 180mg 2 x a day, this did not help, then started on citirizine which just made me even more drowsy than i already was without tablets, i then got prednisilone (steroids) 35mg 2 x a day reducing dose by 5 mg every day. this was amazing all my symptoms disappeared apart from the drowsiness.when the steroid dose became very low my urticaria returned and now the doctors refuse to give me anymore saying it is not a long term option. my face continues to swell i feel like i have been punched in the face repeatedly, when my hands swell they go burning hot and i lose the use of them untill the sewlling goes down, ive been seen by two dermatologists one took blood samples all came back negative no aneamia or thyroid problems or allergens which are all major triggers of urticaria, my condition is now classed as chronic ruling out all allergens however my ana blood test came back positive 1:80 but the dermatologist and my doctor do not think this a cause for concern so until my chronic urticaria compkletely goes away which could take 5 -10 years all they will do for me is continue my anihistamines which have no effect do not stop flare ups and offer no relief.
can someone offer any advice??

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  • http://www.aaaai.org/aadmc/images/barhead.gifSELECTED ARTICLES FROM THE RECENT LITERATURE 200310/2/03Treatment of severe chronic urticaria with cyclosporineSummaryThere is a subset of patients with severe chronic idiopathic urticaria (CIU) unresponsive to antihistamine (AH) therapy. Di Gioacchino et al of the IRRCS San Gallicano in Rome, Italy carried out a double-blind comparison of cyclosporine A (CsA vs AH (cetirizine 10 mg/day for 16 weeks) in 40 adults with severe steroid-dependent CIU and positive autologous serum skin test (ASST). After 2 weeks, the study was opened because of the occurrence of severe relapses in 16 patients (40%) requiring high dose steroid treatment. All these relapses occurred in the AH treatment group. Therefore, all patients were assigned to the Cs treatment group.During the 16 week treatment period, relapses occurred in 20 patients, remitting spontaneously in 8 others. The mean clinical score for the group had decreased significantly compared to baseline levels (p=0.002) with ASST becoming negative in 13 of 16 subjects who went into clinical remission. After 9 months following discontinuation of the CsA therapy, 16 patients were still in full remission with continued reduction in symptom score.CsA was generally well tolerated with a need to reduce the CsA dose in 3 patients because of a reversible increase in the serum creatinine.ReferenceAllergy Asthma Proc 2003;24:285-90
    rad-skw 1,605 Replies Flag this Response
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