Discussions By Condition: I cannot get a diagnosis.

no underlying cause found for SIADH

Posted In: I cannot get a diagnosis. 6 Replies
  • Posted By: Anonymous
  • April 19, 2009
  • 05:05 AM

Help! My mother is a medical mystery right now. She just turned 54, and was very healthy up until this past Thanksgiving. She has a herniated disk in her neck, and it was bothering her at the time, then she ended up ill with headache, nausea, and vomiting for a few days. My dad brought her in to the clinic after several days of this, and they hydrated her then she went home. The following day she literally had to crawl out of bed, and went back to the clinic. Ended up in ICU!

Normal sodium is 135-145 and her's was 107. This was a critical level that could have caused her to have siezures, go in to a coma, or death.She just had mild confusionLab tests show that she definitely has SIADH Syndrome of innappropriatie diuretic hormone. Colonoscopy was normal, and full body scan showed nothing except a small mass on the lung and that her pituitary is flat. She was put on a fluid restriction of 1 quart of fluids a day, but sodium is checked every few weeks, and still is in the low 120's. She had a repeat scan of the chest after one month, and the mass had not changed.

She was referred to the Mayo clinic. Plan was to biopsy the mass on the lung, but was too small. She met with a thoracic surgeon, and it was decided to do surgery. She ended up having 1/4 of the left lower lobe of the lung removed, and it was mass was benign.

So, she has SIADH, and sodium remains low even with the fluid restriction, but they can's find the underlying cause. Plan is to try Demeclocycline, a medication that may help, and she will have the sodium checked every few weeks. She will also meet with endocrinology at the Mayo again in June.

Anyone ever hear of SIADH? Help! I hope to help her figure out what is wrong.

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6 Replies:

  • My Daughter has the exact same issues. We've never seen her sodium that low though.. She's been dealing with this now for 8 years. I'm hoping you are still looking at this thread at least once in awhile.. Did you make it to the Mayo clinic? And if so did they find anything??
    Anonymous 42789 Replies Flag this Response
  • Causes of SIADH:Tumors, Lesion CNS, Drugs( antidepresivum, kolchicin, karbamazepin, chlorpropamid ),pulmonary infection or some autoimmune disease...Maybe this small mass on the lung was problem.How long has she had surgery? Maybe it will soon fix it. Or problem is her pituitary... Sorry for my English
    Anonymous 42789 Replies Flag this Response
  • They've done all the test for those, twice, all negative..
    Anonymous 42789 Replies Flag this Response
  • I too was diagnosed with SIADH. I saw thirteen different doctors over several months but no underlying cause was found until a sleep test revealed that I had severe Sleep Apnea. After using a CPAP machine my sodium level began to slowly rise. After a few months my sodium levels are now back to the normal range and I feel well again. Please test for Sleep Apnea.
    Anonymous 1 Replies
    • September 22, 2014
    • 08:45 PM
    • 0
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  • Last year a blood test revealed that I had very low sodium levels. After undergoing many different tests, I was diagnosed with SIADH. No underlying cause was discovered until after seeing many different doctors one suggested that I have a test for Sleep Apnea. A sleep test revealed that I did have severe Sleep Apnea. Now my sodium levels are back to the normal range and I feel well again. The affect of the CPAP treatment was amazing. Please investigate Sleep Apnea.
    Anonymous 1 Replies
    • September 24, 2014
    • 09:22 PM
    • 0
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  • Wow! I can't believe I came across this again. My mom is now 60. Over the past few years it seemed she adjusted to the low sodium levels and had lab checked monthly. She did get bad headaches when it was too low. I found her to get irritable as well. The Mayo had her get a CT of the chest once a year. No sign of cancer. Within the last 6 months her sodium level has been at the low end of normal and no longer on fluid restriction. Somehow she is back to normal after 6 1/2 years. She does have sinus polyps and snores terribly. I am going to talk to her about the sleep apnea. Hope you are all doing well.
    Anonymous 1 Replies Flag this Response
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