Discussions By Condition: I cannot get a diagnosis.

My CFS puzzle and answer - B6

Posted In: I cannot get a diagnosis. 1 Replies
  • Posted By: marcus80
  • June 10, 2010
  • 02:08 PM

29 years old. Had cfs for 13 years. Tried everything. Recently started taking vitamin b6 and wow! i finally have started to feel better. Getting progressively better, albeit, its taken 4 months and still not better. Why would b6 make me feel so much better?

Although i feel i will recover completely if i continue this course of actioni wonder if anything else will speed it up.

What other supplements should i take to regain full health if ive had a b6 deficiency. I currently take B6, complex B, b12 injections, magnesium, Full spectrum multi vitamin/mineral. I eat impeccably well

Also, what dose of B6 should i take?

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  • Congrats on finding something which works for you with this dreadful illness. For me it was B12 injections which turned the CFS around and got me onto to recovery path again thou i still cant work. (that and finding out I also had POTS and dealing with that too). B6.. Pyridoxine.. something the contraptive pill destroys but i see by your nic you are a guy. (Also partly destroyed with cooking foods.. Sources of B6... brewers yeast, raw wheat germ, navy and soy beans, potato, fish, chicken, red meat, eggs, bananas, spinach, broccoli and raw non pasterised milk). ...... I remember being told during a nutrition lecture at collage that often if one has issues with one B vitamin (deficient) one may also have issues with the other B vitamins. Take care that you arent needing other of the B groups. For B6 my collage notes say the RDA is 2mg per day for adults but some nutritionists recommend up to 25mg per day esp in contraceptive pill users. ........ My CFS specialist has me both on B12 and also B6 (in the active form thou which is "pyridoxal 5 phospate" at the dose of 5-10mg per day, some with CFS do not convert things well so need active forms for best benefit). Why he put me on the B6 (pyridoxal 5 phosphate) is as MANY WITH CFS DO (there are some CFS experts out there who still think this is the cause of CFS), i have a methylation issue, in my case it is a MTHRF polymorphism. (Which was picked up by in the top end of the normal range of "plasma homocysteine" test and then confirmed by a "thrombophilia genotypes" test). Maybe you do have a methylation issue too.. maybe the cause of your CFS??........... i just did some searching for you as have some idea what to look for with this. When i just had a look to see if B6 relates to methylation in any way i found the following at http://en.wikipedia.org/wiki/Vitamin_B6 "Pyridoxal phosphate (PLP) is a cofactor in transaminases that can catabolize amino acids. PLP is also an essential component of two enzymes that converts methionine to cysteine via two reactions. Low vitamin B6 status will result in decreased activity of these enzymes. the above is part of the methylation cycle!!! Methionine is part of this cycle. It appears you have a "Glutathione Depletion-Methylation Cycle Block" in your body and taking the B6 is helping fix it. i suggest to do a search on "methylation cycle" and "CFS". There is CFS treatment plans about for these issues in helping the CFS by treating these blocks. Exactly what your specific one is called (to do with the B6) ive not a clue.. but some CFS experts would be able to tell you which ones are likely in this case with the B6 and exactly which methylation issue you should be tested for. (The methylation stuff is way, way complex!! to much for me to get my head around the whole thing).
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