I am a 20 year old male who has been diagnosed with a primary sleep disorder via a sleep study, extreme difficulty falling asleep mostly, but also a bit of repeated night wakenings too) and have been taking Ambien semi-regularly for over two years now, and usually noting NO tolerance (compared to many other meds including Benadryl, and various benzodizepines such as tempazepam, lorazepam, alprazolam, and clonazepam where usually I get somewhat tolerant after a while). Now my dosage for the Ambien has usually ranged from 5-20mg depending on a lot of factors (what other meds I was taking, how stressed out I was) and that usually did the trick regarding sleep, at least to some degree. Now a few months ago, my pharmacist recommended I try Omega-3 fatty acid dietary supplements. I took them faithfully for a few weeks, and was certainly getting enough active ingredient to notice a psychoactive component to the Omega-3 supplementation, a "mood-brightening" effect (I do not have clinical depression, so far as we know, or bipolar). I also noticed, however, that for some reason, my Ambien seemed to not be working anymore; taking it was like taking placebos. All the other meds I was on at the time (alprazolam and temazepam mostly), seemed unaffected by the Omega-3's. I stopped taking the Omega-3 capsules, and within a few days, the Ambien seemed to be back to working normally, at dosags that I had previously used (5-20mg). In addition all the weird effects of Ambien (sleep-walking, sleep-eating, bizarre behvavior), seemed to dissapear when I took the Omega 3's, at the cost however of the Ambien not seeming to work at all (extreme difficulty falling asleep, and a circadian rhythym disturbance to boot by which my body never wanted to fall asleep at the same time every night, like having daylight savings time go into effect every day. Anyhow, this past month I have taken to drinking Ensure on a fairly frequent basis, and noticed the labeling prominently advertises that it contains a decently large amount of Omega-3's. And once again, my Ambien seemed to have stopped working, to the point where a doctor-prescribed dose of 40mg a night is inneffective (which is a huge dose as Ambien goes). Again, bizaree behaviors have ceased altogether, but taking Ambien once again feels like aking a placebo. Has anyone else, either personally, or in clinical observation or research come across any significant interactions between increased Omega-3 fatty acid intake and a severe decrease in the potency of Ambien? This knowledge would be greatly appreciated.