I have suffered from an extremely intense leg pain since I was very young. My mother, aunt and brother also suffer from this as did my maternal grandmother. At one point my father was told I had anemia and I was put on an iron supplement. This however did nothing t help. At another point my mother was told it was Thalassemia, but there is no mention of lower leg pain in anything we could find. The pain started out every couple of months and as I grew older the pain happened at closer intervals. I have had two children and I am now in my 30's and the pain is almost a daily event. I have seen a neurologist, rheumatologist, oncologist and I am now under the care of a pain facility. I have gone thru bone scans, MRI and CT scans and numerous x-rays. With all of this said and done nothing has been found that can help. Numerous medications have been prescribed from vitamin D supplements to Soma, Ultram, Geneva and even Zoloft. Still nothing helps and the medications seem to make me only tired. The pain can be described as in my lower leg area below my knee. It feels as if my leg is being twisted in opposite directions. Another way to describe it would be someone drilling into my leg. I have often joked if I could just break my leg it would feel much better. The pain usually occurs in my left leg but does sometimes happen in the right. It can happen at any time of the day and exercise, rest, sitting, standing or laying down to not make it start or end. My family history is Anglo Saxons from Ireland, Italy, France, England and Lithuania. There seems to be no answers online for this. Any help would be appreciated.