Discussions By Condition: I cannot get a diagnosis.

Improper methylation leads to every single disease!

Posted In: I cannot get a diagnosis. 3 Replies
  • Posted By: MetalMX
  • February 6, 2009
  • 04:02 PM

I thought this might help all the people on this site with their chronic problems. I know this has certainly opened my eyes.

Improper methylation leads to diabetes, cancer, MS, autistic like features, and peripheral nerve damage and many other chronic diseases. It means the DNA information in your cells is being mis replicated.. But it can be corrected by supplying proper nutrients in the proper form over ride the conversion process. 50% of people are undermethylated and have no clue what is really happening, but it really depends on if there is a genetic mutation with in their cells if it leads to other disease such as cancer, MS, diabetes.

Proper methylation requires nutrients such as Folic Acid, B12, B6, Calcium, Magnesium, TMG (Trimethylglycine), SAMe to name a few.

Their are also about 15% of the population who are overmethylated and who these above nutrients would be disasterous for.


This talks about methylation and its relationship with histamine levels. Generally high histamine means your undermethylated whereas low histamine indicates overmethylation.

Also this link shows you a diagram of the methylation process:


Proper methylation is required for good energy, mood, healing, neurotransmitters, hormones, detoxification, skin, hair, nails, DNA and immunity to name a few.



UNDER METHYLATED = HIGH HISTAMINES, elevated basophils histamine ( > 70)

Conditions associated with undermethylation: Anorexia, Bulemia, shopping/gambling disorders, depression, schizo-affective disorder, delusions, oppositional-defiant disorder, OCD. most exhibit seasonal allergies, perfectionism, strong wills, slenderness, OCD tendencies, high libido, etc.


Overmethylated persons generally exhibit anxiety, absence of seasonal allergies, presence of food/chemical sensitivities, dry eyes, low perspiration, artistic/music interests/abilities, intolerance to Prozac and other SSRI's, etc.

Conditions associated with overmethylation: Anxiety/Panic disorders, anxious depression, hyperactivity, learning disabilities, low motivation, "space cadet" syndrome, paranoid schizophrenia, hallucinations. (Oct 3, 2003)

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3 Replies:

  • I find it extraordinarily ironic that you mention "space-cadet syndrome" as being among the symptoms of the deficiency you describe. That connetation is precisely what comes to mind when I read postings by people who try to pander all sorts of vitamins, minerals, herbs, potions, oils and other concoctions on people seeking medical assistance. There is absolutely nothing within the medical science domain to suggest that "methylation" is responsible for states of health in the human body. It is simply a variation on an age-old theme whereby unsuspecting people are led to believe that they must purchase and consume all sorts of products in order to remain healthy. I'm constrained to point out that if your claims has even a shred of validity, the medical community would waste no time whatsoever in availing itself of such products to rid the world of disease and illness. You have absolutely no idea what you're talking about and there is no medical basis whatsoever for your claims. J Cottle, MD
    JCottleMD 580 Replies
    • February 7, 2009
    • 01:54 PM
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  • Good for you,Dr.Cottle!
    richard wayne2b 1232 Replies
    • February 7, 2009
    • 02:27 PM
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  • Dr. Cottle, While I agree the poster has made completely outlandish statements without evidence, there is some validity to the idea that methylation and histone modification aberrations contribute to disease. Methylation or histone modification refers to the turning on and off of genes by changing their availability for transcription. The current theory states that methylation and modification differences of histones explain why twins with identical genotypes express different disease phenotypes, often not developing the same diseases in life. And you are absolutely right that people pander vitamins, minerals, herbs, and potions to make money off of half-truths and mirages. Furthermore, the medical community would not hesitate to use treatment options that cure patients. However, to say that there is no logical reason that methylation can contribute to disease development and progression is quite frankly false. Similarly, it is equally false to act as if we have begun to even understand the process, let alone claim it is responsible for EVERY disease. In summary, Dr. Cottle, your post is superb except for the assertion that methylation and other forms of histone modification (acetylation, etc) are scientifically unfounded. On the contrary, current research indicates that treatment induced methylation/demethylation may be a possible option for cancer treatment. However, the evidence is only suggestive at this point, not conclusive. Feel free to peruse a couple scientific articles below covering the role of the epigenome in disease.http://www.anti-cancerdrugs.com/pt/re/anticd/abstract.00001813-200201000-00001.htm;jsessionid=JbYDrVqSkmc2N8YBJFv3hWvZ35VYG0b8T3rvjZmcrVmKTJ99JqG1!-2118404334!181195629!8091!-1http://www.ebmonline.org/cgi/content/abstract/229/10/988http://www.nature.com/onc/journal/v21/n35/abs/1205651a.htmlNote: MetalMX, when learning about medicine and scientific discoveries, do not trust information just anywhere on the internet, but only that of published peer-reviewed journals. Research is the only basis for gaining medical and scientific knowledge; thus, you should look to primary literature in order to discern the truth, as the results of research are published in journal articles--not unknown websites in the far-corners of the internet. We all want hope, but place your faith in evidence supported knowledge, not hearsay.
    Anonymous 42789 Replies
    • February 18, 2009
    • 05:23 AM
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