I thought this might help all the people on this site with their chronic problems. I know this has certainly opened my eyes.
Improper methylation leads to diabetes, cancer, MS, autistic like features, and peripheral nerve damage and many other chronic diseases. It means the DNA information in your cells is being mis replicated.. But it can be corrected by supplying proper nutrients in the proper form over ride the conversion process. 50% of people are undermethylated and have no clue what is really happening, but it really depends on if there is a genetic mutation with in their cells if it leads to other disease such as cancer, MS, diabetes.
Proper methylation requires nutrients such as Folic Acid, B12, B6, Calcium, Magnesium, TMG (Trimethylglycine), SAMe to name a few.
Their are also about 15% of the population who are overmethylated and who these above nutrients would be disasterous for.
This talks about methylation and its relationship with histamine levels. Generally high histamine means your undermethylated whereas low histamine indicates overmethylation.
Also this link shows you a diagram of the methylation process:
Proper methylation is required for good energy, mood, healing, neurotransmitters, hormones, detoxification, skin, hair, nails, DNA and immunity to name a few.
UNDER METHYLATED = HIGH HISTAMINES, elevated basophils histamine ( > 70)
Conditions associated with undermethylation: Anorexia, Bulemia, shopping/gambling disorders, depression, schizo-affective disorder, delusions, oppositional-defiant disorder, OCD. most exhibit seasonal allergies, perfectionism, strong wills, slenderness, OCD tendencies, high libido, etc.
OVER METHYLATED = LOW HISTAMINES low histamine (< 40)
Overmethylated persons generally exhibit anxiety, absence of seasonal allergies, presence of food/chemical sensitivities, dry eyes, low perspiration, artistic/music interests/abilities, intolerance to Prozac and other SSRI's, etc.
Conditions associated with overmethylation: Anxiety/Panic disorders, anxious depression, hyperactivity, learning disabilities, low motivation, "space cadet" syndrome, paranoid schizophrenia, hallucinations. (Oct 3, 2003)