Discussions By Condition: I cannot get a diagnosis.

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Posted In: I cannot get a diagnosis. 10 Replies
  • Posted By: Anonymous
  • October 26, 2009
  • 09:36 PM

I am 38 have been sick a while but getting worse. It started 14 yrs ago with shingles, thyroiditis, uveitis both eyes. Now 14yrs later diabeties, mvp, high blood pressure, ostoarthritis, muscle pain, and so on.

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  • I am 38 have been sick a while but getting worse. It started 14 yrs ago with shingles, thyroiditis, uveitis both eyes. Now 14yrs later diabeties, mvp, high blood pressure, ostoarthritis, muscle pain, and so on. Have any of the doctors you have seen considered whipple's? Uveitis points toward this as a possibility but only after ruling out things like celiac, intra-abdominal lymphoma, any of several inflammatory rheumatic disorders like bichet's. I have heard of cases of symptomatic whipple's going on for over 15 before a proper diagnosis is finally given. Definitive diagnosis may require an endoscopy, biopsy with PAS staining for T-whipplei, and/or secondary confirmation with PCR.
    gregtfish 67 Replies
    • October 27, 2009
    • 02:20 AM
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  • I don't think whipples is very likely. diabetes would explain the ocular disturbances. If there is obesity present, that, the high blood pressure and diabetes would explain the osteoarthritis and muscle pain. Even "if" it was whipples, being present for many years it would have taken advantage of the MVP and caused endocarditis long ago.
    Croatiamedstudent 32 Replies
    • October 27, 2009
    • 06:29 AM
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  • 144lb at 5' 7" been tested for celiac already, ruematiod, others have thought lupus. I have alot of muscle pain and bone pain. IBS is running its corse over all these years been scoped nothing realy showed up. Had bone scan just uptake in my knees and hands. Ct shows a fatty liver. I have had gallbladder removed , hystorectomy, both knees scoped. I have a hard time sleeping. I always have a high white count. Cholesterol is out the roof for my age. C-reative protine always high. But all other blood work is fine. I noticed my flare ups more when I have been sick with a cold or virus. Its like my body is attacking itself I have researched to no end. I am a Registard X-ray tech. I am still working but its getting harder and harder to do. I need help no one can put all the puzzle together.I don't think whipples is very likely. diabetes would explain the ocular disturbances. If there is obesity present, that, the high blood pressure and diabetes would explain the osteoarthritis and muscle pain. Even "if" it was whipples, being present for many years it would have taken advantage of the MVP and caused endocarditis long ago.
    Anonymous 42789 Replies
    • October 27, 2009
    • 04:05 PM
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  • 144 5' 7" not over weight... Had colonoscopy no findings... tested for celiac neg. always have high c-reactive protien. High white count. but everything else is normal. My bones look like a 60 year old persons. My body reacts when i am sick. Its like its attacking itself.I have been to rhumatologist, gastorolgist "IBS", no one can tell me anything I don't think whipples is very likely. diabetes would explain the ocular disturbances. If there is obesity present, that, the high blood pressure and diabetes would explain the osteoarthritis and muscle pain. Even "if" it was whipples, being present for many years it would have taken advantage of the MVP and caused endocarditis long ago.
    Anonymous 42789 Replies
    • October 27, 2009
    • 04:23 PM
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  • I assume your alcohol consumption is not of excess, excluding such a reason for the fatty liver. This is interesting......If you have no real apparent reason for the development of all your metabolic syndrome related issues (fatty liver, diabetes, high blood pressure, elevated cholesterol and CRP) which would normally be causes by poor diet lack of exercise etc, then I would look to pancreas. An issue with your pancreas would explain your intestinal disturbances and possibly the development of your metabolic syndrome (which is causing your other widespread issues). Has anyone looked at your pancreas? It's still a theory at this point, I'll post again once I look into this.
    Croatiamedstudent 32 Replies
    • October 28, 2009
    • 04:46 AM
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  • Have not had a drop to drink in 2 years. I had a CT scan yesterday and they found nothing.. I work in a clinic all my blood work looks ok. I do have a lot of pain under my rt side at the ribs. I was thinking what your thinking to. So how do I find out if ct is good any other blood work for this? Thanks so much for your help. I am the only one working my husband 34 was diagnosted with colon cancer a year ago went through surgery and chemo. a year out and is doing well. I assume your alcohol consumption is not of excess, excluding such a reason for the fatty liver. This is interesting......If you have no real apparent reason for the development of all your metabolic syndrome related issues (fatty liver, diabetes, high blood pressure, elevated cholesterol and CRP) which would normally be causes by poor diet lack of exercise etc, then I would look to pancreas. An issue with your pancreas would explain your intestinal disturbances and possibly the development of your metabolic syndrome (which is causing your other widespread issues). Has anyone looked at your pancreas? It's still a theory at this point, I'll post again once I look into this.
    Anonymous 42789 Replies
    • October 30, 2009
    • 03:01 PM
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  • Ok. Lets get a little summary here. First, your bone issue is from hormonal disregulation. the parathyroid releases parathyroid hormone (PTH) in response to low blood calcium, which acts to remove calcium from the bones and add it into the blood (maintain proper blood calcium). In your case, there is likely chronic high levels of PTH causing your bone degredation. You have a fatty liver, high CRP and diabetes. Now, these are under the scope of metabolic disorder (basically everything to do with diabetes, uvetitis, global inflammation, insulin resistance etc.). All your scans, we can assume rule out cyts, tumours (malignant or carcinogen), or intestinal issues. We are left with:-likely parathyroid overactivity,-fatty liver and high CRP, which is both a cause and effect of metabolic syndrom,-Digestive issues, which are increased by overproduction of inflammatory cytokines in the body which are increased in metabolic syndrome (CRP, IL-6 TNF-a all promote inflammation)-Possible effect on the pancrease, likely due to inflammatory cytokines (possibly contributing to your intestinal issues)-A tendency for things to get worse when you are sick (when you are sick, the immune response is also an inflammatory response, IL-6, TNF-a and other pro inflammatory cytokines are released for the purpose of combating the infection)Now, if this chronic low grade inflammatory issue has been present for such a long time, it would explain all of you symptoms. The important assumption is that the imflammatory state, was a cause of the metabolic syndrom and not a result of (in diabetes from obesity, inflammatory state is the result) it.That leaves us with some disorder that causes chronic inflammation and effects multiple systems. This next part is important. Now that I have summarised this nicely people will take it and run with it, you'll get posts on "its sarcoidosis" "its lupus" "its hyperadrenalopathy" "its lyme". At this point don't get caught up in getting a diagnosis, because your symptoms will fit for all of those and many more, but there will be no definite way to choose only one.Treatment, the treatment for inflammatory disorders is steroids (glucocorticosteroids like prednisone). At this point, see if your doc can get you on steroids regardless of what diagnosis is (many of the above are treated with steroids). If you get better then, we know its an inflammation issue. If you don't get better, or have already been on steroids and they haven't worked, well I'm sorry i'm tapped out I don't have a realistic plausible explanation other than this one. I hope this helps out.
    Croatiamedstudent 32 Replies
    • October 31, 2009
    • 07:13 AM
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  • HI,an infectious microbe, such as a virus, triggers the illness.Fibromyalgia -- Fibromyalgia is a common condition characterized by long-term, body-wide pain and tender points in joints, muscles, tendons, and other soft tissues. Fibromyalgia has also been linked to fatigue, morning stiffness, sleep problems, headaches, numbness in hands and feet, depression, and anxiety.Fibromyalgia can develop on its own or along with other musculoskeletal conditions such as rheumatoid arthritis or lupus. Specific symptoms:Body achesChronic facial muscle pain or achingFatigueIrritable bowel syndromeMemory difficulties and cognitive difficultiesMultiple tender areas (muscle and joint pain) on the back of the neck, shoulders, sternum, lower back, hips, shins, elbows, kneesNumbness and tinglingPalpitationsReduced exercise toleranceSleep disturbancesTension or migraine headaches DO ASK YOU R DOCTOR TACK CARE
    charmaine petzer 176 Replies
    • October 31, 2009
    • 01:44 PM
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  • Ct came back normal with onlt a note of edema in the lower lung fields. Thanks for all your help this is somthing i now is inflamitory, but what is triggering it who knows... I am about to give up on it......hi,an infectious microbe, such as a virus, triggers the illness.fibromyalgia -- fibromyalgia is a common condition characterized by long-term, body-wide pain and tender points in joints, muscles, tendons, and other soft tissues. Fibromyalgia has also been linked to fatigue, morning stiffness, sleep problems, headaches, numbness in hands and feet, depression, and anxiety.Fibromyalgia can develop on its own or along with other musculoskeletal conditions such as rheumatoid arthritis or lupus. Specific symptoms:Body acheschronic facial muscle pain or achingfatigueirritable bowel syndromememory difficulties and cognitive difficultiesmultiple tender areas (muscle and joint pain) on the back of the neck, shoulders, sternum, lower back, hips, shins, elbows, kneesnumbness and tinglingpalpitationsreduced exercise tolerancesleep disturbancestension or migraine headaches do ask you r doctor tack care
    Anonymous 42789 Replies
    • November 2, 2009
    • 05:39 PM
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  • HI DONT JUST GIVE UP .LETS TRY AND HELP YOU SOME MORE>IF YOU HAVE NOT BEEN FOR THIS TEST I DO THINK YOU MUST HAVE ITThere is an ANA (antinuclear antibody) test which can be performed on a patient's blood sample as part of the diagnostic process to detect certain autoimmune diseases.Antinuclear antibodies are a unique group of autoantibodies that have the ability to attack structures in the nucleus of cells. The nucleus of a cell contains genetic material referred to as DNA (deoxyribonucleic acid).this test will show any vitus - it is a blood test your doctor can do.tack care
    charmaine petzer 176 Replies
    • November 3, 2009
    • 08:05 AM
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