Discussions By Condition: I cannot get a diagnosis.

Esophageal candida,weight loss; HIV negative

Posted In: I cannot get a diagnosis. 22 Replies
  • Posted By: RachelBullets
  • October 29, 2009
  • 11:08 PM

I have struggling for over two years without being diagnosed with various symptoms, and I'm at my wits end.

I was recently diagnosed with esophageal candidiasis and oral thrush that I had for a month, maybe more. I'm 21 and HIV negative . I've experienced unintentional weight loss, especially recently due to longstanding malabsorption . From what I've been told, oral thrush alone is rare in healthy people my age, let alone esophageal candida. I was anemic for eight years which spontaneously resolved last month, besides that, all CBCs, liver function and pancreatic function panels have been fine, despite my bruising even more than I did when I was anemic.

Any thoughts? I feel like I reached a dead end.

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22 Replies:

  • Do you by any chance have a recent blood test result to post ? The symptoms you are describing are associated with immunosuppression which is probably why you have had so many HIV tests. But there are a number of other rarer conditions which can cause immune suppression. Can only help further if you get a blood test with white cell differential though.
    gungwane 62 Replies
    • October 30, 2009
    • 01:36 PM
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  • Do you have any of the following symptoms?alopecia, vitiligo (blotchy loss of skin pigment), ovarian failure, testicular atrophy, hypothyroidism, gastric parietal cell atrophy, hepatitis, intestinal malabsorption, insulin-dependent diabetes mellitus, sore light-sensitive eyes. Do you have hypogammaglobulinemia?Did you have an ANA tests?What were the results?Have you been check for adrenal and thyroid antibodies?
    Anonymous 42789 Replies
    • October 30, 2009
    • 05:25 PM
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  • Do you have any of the following symptoms?alopecia, vitiligo (blotchy loss of skin pigment), ovarian failure, testicular atrophy, hypothyroidism, gastric parietal cell atrophy, hepatitis, intestinal malabsorption, insulin-dependent diabetes mellitus, sore light-sensitive eyes. Do you have hypogammaglobulinemia?Did you have an ANA tests?What were the results?Have you been check for adrenal and thyroid antibodies?I'm still looking for my last CBC...I've had an ANA and rheumatoid factor, both negative.I have had signs of hepatitis but negative Hep A,B,C screens.I've had intestinal malabsorption of unknown origin...I had 2 upper endoscopies and one colonoscopy all with biopsies, all negative for inflammation.
    RachelBullets 120 Replies
    • October 30, 2009
    • 07:37 PM
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  • Have you looked into the possibility of autoimmune polyendocrinopathy candidiasis ectodermal dystrophy?The symptoms seem to be quite similar to what your experiencinghttp://www.empower.org.nz/http://children.webmd.com/apeced-syndrome
    Anonymous 42789 Replies
    • October 30, 2009
    • 08:32 PM
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  • Have you looked into the possibility of autoimmune polyendocrinopathy candidiasis ectodermal dystrophy?The symptoms seem to be quite similar to what your experiencinghttp://www.empower.org.nz/http://children.webmd.com/apeced-syndromeI have honestly never even heard of it. I have other symptoms, I don't know if that would make that more or less suspicious a culprit.The symptoms are:-Dx of cluster headaches-intermittent severe nausea/vomiting-intermittent night sweats-severe malabsorption diarrhea-arthritis for over 6 years-bone pain for several years -appetite loss-intermittent low grade fevers-long standing coughs after lower respiratory infections-intermittent abdominal pain -intermittent jaundice in my eyes-dark urine, 4 times total-heavy menstrual bleeding for 2 years despite hormonal treatment-now thrush/candida esophagitis
    RachelBullets 120 Replies
    • October 31, 2009
    • 03:57 AM
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  • I have honestly never even heard of it. I have other symptoms, I don't know if that would make that more or less suspicious a culprit.The symptoms are:-Dx of cluster headaches-intermittent severe nausea/vomiting-intermittent night sweats-severe malabsorption diarrhea-arthritis for over 6 years-bone pain for several years -appetite loss-intermittent low grade fevers-long standing coughs after lower respiratory infections-intermittent abdominal pain -intermittent jaundice in my eyes-dark urine, 4 times total-heavy menstrual bleeding for 2 years despite hormonal treatment-now thrush/candida esophagitisWith these symptoms in may be viral hepatitis. Also possible pancreatitis- no enzymes to digest food = no absorption = no nutrients and a whole lot of problems.
    Anonymous 42789 Replies
    • October 31, 2009
    • 02:04 PM
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  • I haven't even finished the Nystatin and the trush looks like its coming back already
    RachelBullets 120 Replies
    • November 1, 2009
    • 00:02 AM
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  • My hep screens were nagative for all viruses, and I was negative for pancreatitis, which was one of the first things they thought it was.
    RachelBullets 120 Replies
    • November 1, 2009
    • 04:21 AM
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  • Have you ever had a bone marrow biopsy ?
    gungwane 62 Replies
    • November 1, 2009
    • 07:57 AM
    • 0
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  • Have you ever had a bone marrow biopsy ?No. I honestly think no one would consider giving me one. I've been seeing a hematologist/oncologist, he recently tested me for porphyria, but he said if its negative I'll have to go to a research hospital, Shands. I see him on the 6th of November, I called his office to let him know about the thrush issue, maybeit'll make him more concerned? It seems more logical to me that I could have a leukemia or lymphoma than porphyria, just statistically. You can't say that, though.
    RachelBullets 120 Replies
    • November 1, 2009
    • 05:31 PM
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  • hey there. I dont know if this is the same thing, but i experienced something similar, i had fungul growing in the back of my throat, right behind my tonsils, the back wall of my throat and going down. It was very hard for the doctors to see it. I had went to the doctors on 2-3 different occasions because they kept missing at looking at what i was talking about and relating my problem to gerd. Finally i brought my own mirror and bright flashlight for the doctors to finally see, which they did finally and took some 3 different swabs and it came back positive for fungus. I know its very rare for my age to get this at 28yrs. I was told to take a hiv test because the doctors say its commomn in hiv patients to get this. I knew i was negative for that too, which it came back negative as well. Im still baffled how this fungus problem came about for myself. The symptoms where one of the worst things i have ever encountered in my throat. So different from a sore throat. The worst ever. It was very hard to swallow, especially food was very difficult to eat, the back of my throat felt really raw and i always had a blood taste in my mouth, i did spit up a little blood,too. My throat felt so misrable with other symptoms, too. I was give some antifungal pills at first which didnt clear it up, then i was given some antifungal syrup which i believe cleared this frustrating problem away. I feel much better now, i realized i had this problem in feb, 2009 and clearded away by mid april of 2009. I hope u get better n find out why u are feeling how u r feeling.
    GEMINI 21 Replies
    • November 1, 2009
    • 09:45 PM
    • 0
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  • It seems more logical to me that I could have a leukemia or lymphoma.I'm only a 3rd year medical student in South Africa, so I'm not claiming to know all that much, but I have seen a LOT of patients with HIV all of whom present with symptoms exactly like yours. If you are HIV negative then there is something else attacking or destroying your immune system. Whatever it is you need to find it. A porphyria is extremely rare for starters and wouldn't compromise your immune system in the way you have described. You are right a leukaemia fits much better. Thats why it is crucial that you get a blood test with white cell differential to rule it out. If that shows abnormalities then bone marrow biopsy should be next. I may be thinking along lines that other doctors far more experienced than I have already gone down, but unfortunately seeing as I don't have access to your medical history, or even the chance to meet you talk to you and take a history it is all I can do.
    gungwane 62 Replies
    • November 2, 2009
    • 06:23 AM
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  • I've never had a white cell differential be abnormal besides when I had a long standing kidney infection.But after my anemia resolved, well, actually before, when my MCH and MCV were still low and my RDW still high, my RBC count has been a little high but that's about it, and only with certain lab ranges. Last it was 5.7Also, last night, not the first time this has happened, I got severe epigastric pain. Sometimes it feels like tearing. I have to stick my fist underneath my ribs to get the pain to subside. I was tempted to go to the ER, but they would just do the same thing they always do. "You're okay, here's some painkillers," and send me home.
    RachelBullets 120 Replies
    • November 2, 2009
    • 04:40 PM
    • 0
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  • I have struggling for over two years without being diagnosed with various symptoms, and I'm at my wits end.I was recently diagnosed with esophageal candidiasis and oral thrush that I had for a month, maybe more. I'm 21 and HIV negative . I've experienced unintentional weight loss, especially recently due to longstanding malabsorption . From what I've been told, oral thrush alone is rare in healthy people my age, let alone esophageal candida. I was anemic for eight years which spontaneously resolved last month, besides that, all CBCs, liver function and pancreatic function panels have been fine, despite my bruising even more than I did when I was anemic.Any thoughts? I feel like I reached a dead end.May be cancer of the digestive track?
    Anonymous 42789 Replies
    • November 3, 2009
    • 05:17 AM
    • 0
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  • Epigastric pain is a classic symptom of porphyria. Does exposure to sunlight seem to worsten your symptoms ? If your WBC differential is normal than I have no more ideas, I'm sorry. Just to reassure you that I do think something is wrong, and you should keep searching until eventually you do find out what it is. If not prophyria then maybe one of the other rarer WBC abnormalities. Let me know what your porphyria test results are.
    gungwane 62 Replies
    • November 3, 2009
    • 05:36 AM
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  • Sunlight doesn't necessarily make them worse. It just gives me a burning feeling on my skin, even through windows after just a minute ot two.
    RachelBullets 120 Replies
    • November 3, 2009
    • 05:44 PM
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  • May be cancer of the digestive track?I would think I was too young for that, even with my family history of cancer, particularly colon, breast, and ovarian. I haven't had an upper GI series of x-rays in about 2 years, maybe that's a good idea. I'm not exactly sure how much of your small intestine they can see with a combo of upper and lower endoscopies. I know that I have no ulceration and no signs of inflammation on biopsy, which surprised me because of the blood, sometimes oil and mucus in my stool.
    RachelBullets 120 Replies
    • November 4, 2009
    • 03:06 AM
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  • The porphyria tests were negative.Most recent CBC as follows:WBC 6.0LYM% 34.3LYM# 2.0MON% 4.1MON# 0.2GRA% 61.6GRA# 3.8RBC 4.86HGB 13.8HCT 40.8MCV 84MCH 28.4MCHC 33.9RDW 16.7PLT 230MPV 7.6
    RachelBullets 120 Replies
    • November 6, 2009
    • 07:27 PM
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  • My neck on the right side has been swollen since about 2 this morning. The ER did nothing, they said it wasn't even swollen, even though it is. Behind my ear, to about an inch back, then about 2 inches up is all swollen, and the thrush has come back and taken over my entire mouth. I have no fever, but the tendon in my neck in the front right side is hard, and gets hard and painful because those glands swell a lot. I'm so confused.....can anyone help? I'm overwhelmed :(
    RachelBullets 120 Replies
    • November 8, 2009
    • 09:31 PM
    • 0
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  • Was set up with a GI at the research hospital, but was diagnosed with PID yesterday, and was put on 3 antibiotics, even though I have thrush and just was tested for STDs and was negative.
    RachelBullets 120 Replies
    • November 15, 2009
    • 00:28 AM
    • 0
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