Discussions By Condition: I cannot get a diagnosis.

Daughter has been sick for 1 year with headaches/stomaches/rash/high ASO Titer

Posted In: I cannot get a diagnosis. 6 Replies
  • Posted By: MomofOne
  • October 16, 2007
  • 05:33 AM

Hi,
If anyone has any ideas, I would love to hear them.
My daughter has been sick for almost a year. It started with two concurrent strep infections. After the second one, she had a constant headache and stomach ache that never goes away. She was on numerous antibiotics and sulfa drugs but nothing has worked. Her ASO Titer has gone up and down and is most recently at 440 even though it has been 1 year since she tested positive for strep. She has frequent joint pain but her main complaints are the stomach and head aches.
Recently, shy broke out in a rash on her face that resembled the butterfly rash that many lupus patients get but all her blood work has come back negative for lupus. Although, her symptoms are pretty similar. She is frequently warm to the touch and her lymph nodes and glands are often swollen.
She had a biopsy months ago of her lymph nodes and the revealed a staph infection and enterbacter that was treated with sulfa drugs.
We recently put her on a short term dose of prednisone but it hasn't seemed to help.
Any ideas, help, would be appreciated. She has missed a year of her life and is very young so this is incredibly painful to watch.


Thanks!

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6 Replies:

  • Signs and symptomshttp://upload.wikimedia.org/wikipedia/en/thumb/a/a0/Scarlet_fever_1.jpg/140px-Scarlet_fever_1.jpg The "slapped cheeks" and "white mustache" of scarlet fever.http://upload.wikimedia.org/wikipedia/en/thumb/f/fa/Scarlet_fever_2.jpg/140px-Scarlet_fever_2.jpg The scarlet fever rash.http://upload.wikimedia.org/wikipedia/commons/thumb/0/02/Scharlach.JPG/180px-Scharlach.JPG Tongue with a strawberry appearance.Early symptoms indicating the onset of scarlet fever can include: Fever of 38 to 40 degrees C.(101-104 degrees F.)FatigueSore throatHeadacheNausea or VomitingAbdominal painFlushed face with perioral pallor (circumoral pallor)Tachycardia (rapid pulse)Lymphadenopathy (enlarged lymph nodes)Punctate red macules on the hard and soft palate and uvula (ie, Forchheimer spots).Bright red tongue with a "strawberry" appearanceCharacteristic rash, which:is fine, red, and rough-textured; it blanches upon pressureappears 12–48 hours after the fevergenerally starts on the chest, axilla (armpits), and behind the earsis worse in the skin foldsPastia lines (where the rash becomes confluent in the arm pits and groins) appear and persist after the rash is goneThe rash begins to fade three to four days after onset and desquamation (peeling) begins. "This phase begins with flakes peeling from the face. Peeling from the palms and around the fingers occurs about a week later and can last up to a month." Peeling also occurs in axilla, groin, and tips of the fingers and toes.Diagnosis of scarlet fever is clinical. The blood tests shows marked leukocytosis with neutrophilia and conservated or increased eosinophils, high ESR and CRP , and elevation of antistreptolysin O titer. Blood culture is rarely positive, but the streptococci can usually be demonstrated in throat culture. The complications of scarlet fever include septic complications due to spread of streptococcus in blood and immune-mediated complications due to an aberrant immune response. Septic complications, today rare, include otitis, sinusitis, streptococcal pneumonia, empyema thoracis, meningitis and full-blown septicaemia ( malignant scarlet fever). Immune complications include acute glomerulonephritis, rheumatic fever and erythema nodosum. The secondary scarlatinous disease (or secondary malignant syndrome of scarlet fever) included renewed fever, renewed angina, septic ORL complications and nephritis or rheumatic fever and is seen around the 18th day of untreated scarlet fever. Has she had any of the rashed associated with scarlet fever?
    rad-skw 1605 Replies
    • October 16, 2007
    • 08:36 AM
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  • Her rash was more typical of the butterfly rash that lupus patients have. And she has been sick for 1 year. I would think that Scarlet Fever would had been diagnosed by now...but who knows! I do believe whatever she has is the result of the strep infection but it seems like most of those complications have been ruled out. Although, I am investigating Scarlet Fever a bit more.
    MomofOne 5 Replies
    • October 17, 2007
    • 03:10 AM
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  • Wow, sounds similar to our situation. My daughter is 10, and her ordeal also started with 2 back to back strep infections. Then she developed mono-like symptoms which turned out to be human parvovirus B19 (commonly known as fifth's disease). Her symptoms were low grade fever, rash, minor joint pain,headache, sore glands, and fatigue. She was on home instruction from school from February 2006 until end of year. She never returned to school. She slowly improved, but was never what I would consider 100%. She still gets fatigued, and has attended school about half the time this fall. Now we are off to a rheumatologist because her ANA titer is 1:320. Her pediatrician is hopeful it is not Lupus, because her other symptoms are better. She still gets fatigued easily, and only has headaches occasionally. However, now she is having stomach pain that she didn't have before.
    Anonymous 42789 Replies
    • October 17, 2007
    • 03:32 PM
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  • I am having some similiar problems. My problems started about 3 years ago with pain in my thighs right above my knees on both legs. I described it as bone pain, like growing pains. I started having a low grade fever a year ago. I went to the doctor a year ago with the fever and leg pain. I recently went to a physical therapist and she seemed to think it is muscle weakness. But, that does not explain the fever. I also have bad migraines. I have been to an infectiouse disease specialist and a pain specialist. I am going to see a Rhuematologist in two weeks. I was put on Verapamil for the headaches and elevated blood pressure. The headaches have gotten better. I still hurt all day and have fever everyday all day. I do have a high ASO titer. The first test was 394. The second was 334. The infectious disease specialist said that I don't have an infection because the antibiotics would have treated that. So, she said it was not strep infection. My fever is between 99 and 99.6. They don't consider that a fever. But, I don't feel good and and I know when my temp is up. I am hot and feel warm to the touch.
    Anonymous 42789 Replies
    • October 17, 2007
    • 08:27 PM
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  • Hi, To the unregistered user of the 10 year old with similar symptoms. I would love to talk more with you. It does sound very very similar and would love to email you with anything you find out. Respond to this and maybe we can figure out a way to stay in touch. We have seen Infectious Disease, Rhuematology, Hematology, Oncology, GI.....!No once can figure out what is wrong. Only her Family Doctor believes she is sick. Please reply again if you are interest in emailing! I would love to have someone to swap ideas with. I have been homeschooling my daughter for a year.
    MomofOne 5 Replies
    • October 18, 2007
    • 01:50 AM
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  • I have been sick for 3 years with the exact same sympthms..My dr has been treating me for suspected Rhumatic fever. After a year I felt much better, then she took me off and I got sick again. She started me back on the injections and about a year later I was getting better. She took me off again 3 months ago.... am not getting sick again.... She has only treated one other case so she really didnt know if that was what I had. I also had spotted rocky mountain fever... I have a rash, fatigue, low grade fever off and on, mild to severe body aches, headches, blurred vision, etc... the list goes on and on.... I recently was told about BRAGGS ORGANIC APPLE CIDER WITH THE MOTHER. You can get it at health food stores. My friend has severe arthritis. He takes 1 TSP in the morning and 1 at night. He said that with in 7 days his pain was gone...ASO titer is strep in your body.... It is in the arthritis catagory.... I just tarted it today. It is totally nasty but I am willing to try anything. it has many other health bennifits.....
    Anonymous 42789 Replies Flag this Response
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