Since 2001-2002, I have experienced extreme pain in both of my shins. The pain is only in the interior of the shin area and stretches for about 5 inches up the shin. It started when I was playing competitive volleyball, so initially we thought it was shin splints. The pain eventually lead me to quit, and 7 years later the pain has stayed the same. I have tried: total rest, years of physical therapy, arch supports, and surgery for compartment syndrome.
I also went to Mayo Clinic where they told me it wasn't fractures or cancer, but they couldn't tell me what it was.
I've been on lots of medication and only 2 helped, so I think that might be a clue as to what it is. Vioxx totally took the pain away, which is an anti-inflammatory. The only other med to help was percocet, but it made me drowsy and fatigued so I quit taking it. The following includes a list of meds I have tried that were totally ineffective (I list this b/c it might help in a diagnosis): gabapentin (neurontin), lyrica, cymbalta, nortriptyline, hydrocodone, advil, ib-profin.
At the time I did complain of fatigue, which seemed to start around the time or soon after I started having the shin pain. I had no psychological problems at that time, no stress/anxiety, no sleep problems, no depression, I was a happy high school student. I also had bad overactive bladder.
The pain get worse with activity.