Discussions By Condition: I cannot get a diagnosis.

Chronic Fatigue, Immune Dysfunction & M.E.

Posted In: I cannot get a diagnosis. 14 Replies
  • Posted By: Eatafruit78
  • June 8, 2007
  • 03:24 PM

Is CFS Linked to Vaccinations?
By Charles Shepherd, MD,
ME Association, United Kingdom

There is widespread agreement that a variety of infections are capable of precipitating chronic fatigue syndrome (CFS) in susceptible individuals. In l988, Lloyd et al reported that several of their patients had linked the onset of CFS to receiving a vaccination in the absence of any coincidental infection.l Since then, other anecdotal reports have also linked vaccinations to the onset of CFS.2,3

The explanation for vaccine-induced CFS may be because the primary purpose of any vaccine is to mimic the effects of infection on the immune system. If an antigenic challenge by infection can precipitate CFS, then it is conceivable that vaccines could act in a very similar manner.

This reasoning is further strengthened by the fact that immunologically based illnesses, such as arthritis, can occur when a susceptible host and an environmental trigger, such as an infection or vaccination, interact.4 It is also interesting to note that vaccinations have been suggested as a possible precipitating factor in the development of Gulf War illness.
Causal vaccines
My research interest in this aspect of developing CFS is largely based on clinical evidence from patients seen in my practice over the past 10 years. As a result, I have gathered details on more than 200 patients with a history of either developing CFS or experiencing a significant relapse/exacerbation of CFS symptoms following a vaccination.

In addition, I have more than 150 reports referring to such a link from members of myalgic enceph-alomyelitis (ME) or CFS self-help support groups and/or their physicians throughout the world.

This data (although unpublished) suggests that tetanus, typhoid, influenza, and hepatitis B are the most commonly implicated vaccines in cases of CFS. I have reports of very few cases involving hepatitis A (using immunoglobulin), polio, or rubella vaccine, or those predominantly given during childhood—-with the possible exception of Bacillus Calmette--Guerin vaccine (three cases).

Almost all of my cases involve adults, and in a significant minority the vaccine was administered when the person had not yet fully recovered from an infective illness such as infectious mononucleosis (known as glandular fever in the U.K.) or had already experienced an adverse reaction to a previous dose of the same vaccine (as is sometimes the case with hepatitis B accine).

About one third of my cases involve vaccine-induced/exacerbated CFS following receiving the hepatitis B vaccine (HBV). Most of these patients are health care workers, particularly nurses. Most of the other patients received HBV for occupational health purposes, often as a condition of employment and without any information on side effects, such as severe neurological reactions.

The prognosis in this group has been poor, with less than 10% of the patients I have personally followed reporting any significant relief of CFS symptoms.

Although chronic debilitating fatigue is the most frequently reported symp-tom of CFS after vaccine administration in this group, around 20% also complained of significant joint pain/arthralgia, a finding consistent with several reports linking HBV to arthritis and other autoimmune disorders.5

Less than 5% of the patients also reported neurological complications/side effects such as tremors or one-sided weakness, which appear to be separate from their CFS symptoms.



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14 Replies:

  • For instance, one female patient developed an acute disseminated inflammation of the brain and spinal cord (encephalo-myelitis) shortly after the second dose of vaccine. This was followed by the gradual onset of CFS.Hepatitis vaccines are highly immunogenic compounds, and a number of possible explanations exist as to why they may be more likely to trigger CFS.One explanation involves a preexisting genetic susceptibility, which after antigenic stimulation with HBV, results in a pathological process (possibly involving immune complex formation) leading to a clinical disease. Another explanation is that a hypersensitivity reaction occurs to a component of HBV, such as the preservative thimerosal.6Researchers in Canada, who made similar observations of a link between HBV and CFS, hypothesized that this may involve an autoimmune reaction with a microscopic form of demyelination not visible on magnetic resonance imaging.7Despite growing anecdotal evidence from other experienced physicians who also believe that HBV can precipitate CFS,2 vaccine manufacturers do not acknowledge any causal link. In fact, a report by an independent working group in Canada that dismissed any such causal link is frequently quoted as a reason for dismissing these claims, even though it contained some very questionable assumptions to support the conclusions.8For example, the report inaccurately states that chronic carriers of hepatitis B infection without signs of ongoing liver damage do not complain of tiredness. The report also uses results from a one-week follow-up study of 700 health care students, which found excessive short-term tiredness in about 14% after vaccination with HBV to refute any link with chronic fatigue. Practical adviceHealth care providers caring for CFS patients who require vaccinations clearly must weigh the pros (i.e., how effective? how necessary?) and cons (i.e., risks of adverse effects and exacerbation of CFS symptoms) for each individual vaccine. I would advise against having routine nonessential vaccinations if a patient is: In the very early stages of CFS, particularly when it obviously follows an infective episode; Continuing to experience flulike symptoms, including sore throat, enlarged glands, fevers, and joint pains; or Has previously experienced an adverse reaction to that particular vaccine.If the vaccination is potentially lifesaving, then considerations relating to CFS must take a lower priority. As for some of the more commonly required vaccines, my advice on their use is as follows:Hepatitis A. Short-lived protection using immuno-globulin does not seem to cause any problems in CFS patients. I have not received any adverse feedback from CFS patients who have used hepatitis A vaccine.Hepatitis B. If a patient requires HBV for occupational health purposes, clinicians should weigh the pros and cons as previously discussed and then discuss with the patient.Influenza. If a patient has any medical condition that could be severely affected by an attack of the flu, such as heart disease, asthma, or bronchitis, influenza vaccine should certainly be considered.My own data indicates approximately 60% of CFS patients experience some form of exacerbation in their fatigue and flulike symptoms (sometimes quite marked) following an influenza vaccine. Meningitis C. My feedback from approximately 30 children and adolescents with CFS who have been given the meningitis C vaccine in the U.K. is that there were no serious side effects or exacerbations of CFS symptoms. The only adverse effects reported have been minor exacerbations of fatigue and headache.Polio and diphtheria. One research study showed evidence that people with CFS do not experience adverse reactions to polio vaccination.9 This is also my own impression from feedback received from patients I have advised receive polio boosters in relation to foreign travel. Polio vaccinations or boosters should clearly be given to patients traveling to countries where polio still occurs. The same advice applies to diphtheria, which is becoming increasingly common in parts of Eastern Europe. Tetanus. Maintaining up-to-date protection is vital for individuals whose employment (e.g., working on a farm) or leisure activity (e.g., gardening) places them at risk of contracting tetanus.However, tetanus vaccine can produce side effects in healthy people and may well cause CFS patients to relapse. The pros and cons need to be carefully considered as tetanus vaccine has been reported to precipitate CFS.1,2Typhoid. The typhoid vaccine can cause side effects in healthy people. The feedback I received from my CFS patients, however, indicates that the oral form of typhoid vaccine was generally well tolerated.Whenever vaccinations are considered necessary, they should be given when CFS patients are feeling reasonably well and not under any undue stress. It is also wise to make sure that all travel vaccinations are completed at least two weeks before departure in the event a patient experiences exacerbated symptoms or a relapse.Not surprisingly, patients with possible vaccine-induced CFS often face considerable difficulty in obtaining disability benefits on the grounds of permanent ill health. However, some of my patients in the U.K. have successfully argued their cases and been awarded injury payments on the grounds that HBV given for occupational health reasons caused their CFS. I am also involved in a number of cases where the debate is likely to be settled in court.References Lloyd A et al. What is myalgic encephalomyelitis? Lancet. l988; l: 1286-7. Weir W. The post-viral fatigue syndrome. Current Medical Literature: Infect Dis. l992; 6: 3-8. CIBA Foundation. Chronic Fatigue Syndrome. Eds. Bock GR et al. J Wiley; l993; symposium 173. Symmons DPM et al. Can immunisation trigger rheumatoid arthritis? Ann Rheum Dis. l993; 52: 843-844. Gross K et al. Arthritis after hepatitis B vaccination. Scand J Rheum. l995; 24: 50-2. Grotto I et al. Major adverse reactions to yeast-derived hepatitis B vaccines—a review. Vaccine. l998; 16: 329-34. Hyde B. The clinical investigation of acute onset ME/CFS and MS following recombinant hepatitis B immunisation. Second World Congress on CFS and Related Disorders, Brussels. 1999; September 9-12. Report of the working group on the possible relationship between hepatitis B vaccination and the chronic fatigue syndrome. Canad Med Assoc J. l993; 149: 314-9. Vedhara K et al. Consequences of live poliovirus vaccine administration in chronic fatigue syndrome. J Neuroimmun. l997; 75: 183-95.Dr. Charles Shepherd is in private practice in the United Kingdom (U.K.) and is a member of the Chief Medical Officer’s Working Group on CFS/ME at the U.K. Department of Health. http://www.cfids.org/images/footer.gif
    Eatafruit78 960 Replies Flag this Response
  • For instance, one female patient developed an acute disseminated inflammation of the brain and spinal cord (encephalo-myelitis) shortly after the second dose of vaccine. This was followed by the gradual onset of CFS. Another explanation is that a hypersensitivity reaction occurs to a component of HBV, such as the preservative thimerosal.6 Despite growing anecdotal evidence from other experienced physicians who also believe that HBV can precipitate CFS,2 vaccine manufacturers do not acknowledge any causal link. _____________________________________________________________________Hi Fruity, Thank you for this very valuable information. Funny, I used to use a soft contact lens solution called HYDROCARE, I think, in 1987 that contained the preservative THIMERESOL. Yes, that is over 20 years ago, but I remember because I had an allergic reaction to the Thimeresol. I used the solution for about a week before my eyes turned so red and burned so bad I couldn't open them!!!!! My Dr./optometrist said I should only use contact lens solutions that had no preservatives in them from then on. So, my eyes are very close to my brain...and I was putting MERCURY in them! I wonder if the Dr. reported my allergic reaction to the eye solution manufacturer. How many others had this reaction to this very common contact lens disinfectant? If they had, wouldn't it have made sense NOT to put it in the vaccines...something injected directly into your body? Here's another funny: Several years later, I got the Hep B vaccine! I had an allergic reaction also. My dr. wasn't sure why I had the reaction, but said she would not continue the series for me and that I should list Hep B vaccine when anyone asked me if I had an allergy. Good thing I've refused to get any vaccines since, because I very likely have CFS/ME! I can not help but have a bitter tone to this message. I am in pain, young, and have debilitating symptoms....and the likely cause is caused by the healers themselves! I would bet a hundred million dollars that when a drug to treat CFS/ME hits the market, just about everyone will be diagnosed with the disease no one believes in. For those of you that have any of the symptoms of CFS/ME...think twice and let it sink in. It is not the answer I wanted to hear, but it is my answer. It is ME.
    Anonymous 42789 Replies Flag this Response
  • I know the feeling. I have beein immunized with many vaccines as a child and more as a healthcare professional. I've had the influenza vaccine for many years running, the Hep B series and a tetanus recently because mine had expired. I was diagnosed by a neurologist last week with CFS. There is a real connection to all of this and CFS is not just the lazy person's choice for an excuse to live an easy life. It's real, affecting many of us and ruining lives, families and society everyday. The amount of people on this site with similar symptoms is astounding.
    Anonymous 42789 Replies Flag this Response
  • Oh no!Both things happened to me!I had an allergic reaction to my contanct lenses solution - back in 1997, and I had been given Hepatitis B vaccine prior to that but I did not complete the series because of how sick I felt!- One of my eyes grew so big- I could not open it!Thanks for your comment!Fruity.
    Eatafruit78 960 Replies Flag this Response
  • I am new to this board but really appreciate you posting this great information. I was diagnosed with Hepatitus D over 12 years ago when I was in the Military overseas and have recently been sick with CFS type symptoms for about 6 months now and upon having blood tests was told that I had Heptatitus B and not D and that it was inactive. The symptoms I have been having are Chronic lower left absominal pain, bruning/tingling sensations in my face arms, back and other parts of my body that comes and goes. Constant nausia and chronic fatigue where I just dont feel like doing anything. i also have tingling on my scalp and nubmness that comes and goes in my arms, hands, legs and feet and ocassional buttocks. I also have a sligh non raised circular rash on both cheeks in my face that tend to burn and tingle often. I wonder if the hepatitus has something to do with all this. i have seen many specialist and have had much blood work done to no avail. I was tested for HIV 1 & 2 in December 06 and test came back negative. I am 36 years old and never feel well any more. I also have chronic pain in my groin and testicals and urniate often, about every 30 minutes. I wake up in the night with severe abdominal and groin pain that seems to be a little better after urinating. I also have stinging pain iside penis and slight readness on the head of the penis and sometimes pain after inercourse. I was recently diagnosed with B12 deficiency so I don't know if this has to do with anything or not and have been recieving injections for about 2 weeks now and i have not seen any improvement with any of my symptoms.
    Bstyck 5 Replies Flag this Response
  • Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.Chronic fatigue syndrome (CFS) is characterized by severe disabling fatigue lasting for more than 6 months associated with physical and mental disturbances such as headache, arthralgia, myalgia, memory impairment, sore throat and tender lymph nodes. The exact pathogenesis is still unknown. Several models were proposed to explain its etiology including chronic infection, endocrine dysfunction, autonomic imbalance, depression, decreased immunity states and an aberrant reaction to infection. No convincing evidence was found to support any of the suggested pathogenic mechanisms. The current concept is that CFS pathogenesis is a multi factorial condition in which an infective agent cause an aberrant immune response characterized by a shift to Th-2 dominant response. When the response fails to be switched-off, a chronic immune activation occurs and clinically expressed as the symptomatology of CFS. Vaccinations are used in order to stimulate the immune system to induce a persistent immunity against the favorable antigens. Several syndromes that contain chronic fatigue as one of their symptoms, such as "Gulf war syndrome" and macrophagic myofasciitis were related to vaccinations. Can vaccinations induce the aberrant immune response of CFS? Little is known about this issue. There are some reports on CFS occurring after vaccination, but few prospective and retrospective studies failed to find such an association. A working group of the Canadian Laboratory Center for Disease Control (LCDC) that was founded in order to examine the suspected association between CFS and vaccinations concluded that there is no evidence that relates CFS to vaccination. Further studies are requested to examine this issue since it is very conceivable that if infection can lead to CFS, vaccination may also lead to it in the same immune-mediated pathogenesis.PMID: 17364497 there are many more symptoms than is mentione here of Chronic Fatigue Syndrome/Gulf War Syndrome
    Anonymous 42789 Replies Flag this Response
  • Is CFS Linked to Vaccinations? By Charles Shepherd, MD,ME Association, United KingdomThere is widespread agreement that a variety of infections are capable of precipitating chronic fatigue syndrome (CFS) in susceptible individuals. In l988, Lloyd et al reported that several of their patients had linked the onset of CFS to receiving a vaccination in the absence of any coincidental infection.l Since then, other anecdotal reports have also linked vaccinations to the onset of CFS.2,3The explanation for vaccine-induced CFS may be because the primary purpose of any vaccine is to mimic the effects of infection on the immune system. If an antigenic challenge by infection can precipitate CFS, then it is conceivable that vaccines could act in a very similar manner.This reasoning is further strengthened by the fact that immunologically based illnesses, such as arthritis, can occur when a susceptible host and an environmental trigger, such as an infection or vaccination, interact.4 It is also interesting to note that vaccinations have been suggested as a possible precipitating factor in the development of Gulf War illness. Causal vaccinesMy research interest in this aspect of developing CFS is largely based on clinical evidence from patients seen in my practice over the past 10 years. As a result, I have gathered details on more than 200 patients with a history of either developing CFS or experiencing a significant relapse/exacerbation of CFS symptoms following a vaccination. In addition, I have more than 150 reports referring to such a link from members of myalgic enceph-alomyelitis (ME) or CFS self-help support groups and/or their physicians throughout the world.This data (although unpublished) suggests that tetanus, typhoid, influenza, and hepatitis B are the most commonly implicated vaccines in cases of CFS. I have reports of very few cases involving hepatitis A (using immunoglobulin), polio, or rubella vaccine, or those predominantly given during childhood—-with the possible exception of Bacillus Calmette--Guerin vaccine (three cases). Almost all of my cases involve adults, and in a significant minority the vaccine was administered when the person had not yet fully recovered from an infective illness such as infectious mononucleosis (known as glandular fever in the U.K.) or had already experienced an adverse reaction to a previous dose of the same vaccine (as is sometimes the case with hepatitis B accine).About one third of my cases involve vaccine-induced/exacerbated CFS following receiving the hepatitis B vaccine (HBV). Most of these patients are health care workers, particularly nurses. Most of the other patients received HBV for occupational health purposes, often as a condition of employment and without any information on side effects, such as severe neurological reactions.The prognosis in this group has been poor, with less than 10% of the patients I have personally followed reporting any significant relief of CFS symptoms.Although chronic debilitating fatigue is the most frequently reported symp-tom of CFS after vaccine administration in this group, around 20% also complained of significant joint pain/arthralgia, a finding consistent with several reports linking HBV to arthritis and other autoimmune disorders.5 Less than 5% of the patients also reported neurological complications/side effects such as tremors or one-sided weakness, which appear to be separate from their CFS symptoms.I think you may find some answers at ilads.org. also check out signs and symptoms at lyme.org. Not to minimize the effects of vaccines especially the preservative that uses mercury, which may be secondary to Borella burgdorferi infection. The symptoms you describe all fit B. burgdorferi.good luckinfection.
    Anonymous 42789 Replies Flag this Response
  • I am new to this board but really appreciate you posting this great information. I was diagnosed with Hepatitus D over 12 years ago when I was in the Military overseas and have recently been sick with CFS type symptoms for about 6 months now and upon having blood tests was told that I had Heptatitus B and not D and that it was inactive. The symptoms I have been having are Chronic lower left absominal pain, bruning/tingling sensations in my face arms, back and other parts of my body that comes and goes. Constant nausia and chronic fatigue where I just dont feel like doing anything. i also have tingling on my scalp and nubmness that comes and goes in my arms, hands, legs and feet and ocassional buttocks. I also have a sligh non raised circular rash on both cheeks in my face that tend to burn and tingle often. I wonder if the hepatitus has something to do with all this. i have seen many specialist and have had much blood work done to no avail. I was tested for HIV 1 & 2 in December 06 and test came back negative. I am 36 years old and never feel well any more. I also have chronic pain in my groin and testicals and urniate often, about every 30 minutes. I wake up in the night with severe abdominal and groin pain that seems to be a little better after urinating. I also have stinging pain iside penis and slight readness on the head of the penis and sometimes pain after inercourse. I was recently diagnosed with B12 deficiency so I don't know if this has to do with anything or not and have been recieving injections for about 2 weeks now and i have not seen any improvement with any of my symptoms.Best thing is a Doctor of Oriental Medicine who works with NAET.Learn about NAET at naet.com - it is the best thing I know that reverses CFS symptoms permanently. Also try Reiki.Best.
    Eatafruit78 960 Replies Flag this Response
  • It is interesting reading here about the possible causes of C.F.S/M.E from vaccines. I have had chronic fatigue type symptoms that have been undiagnosed now for years. I am 40 this year and have lived a miserable existance with this condition which as far as I can remember I have suffered far back into childhood with no time of good health, so I dont fit into the category of C.F.S/M.E!!!. Nor do I suffer the joint pains often associated with these conditions.I would therefore value any opinion as to what this could be and i would value any knowledge od specialist practioners in the U.K which might be able to throw light on the matter. I too am having immense difficulties getting disability benefits here as getting D.L.A is almost impossible, I have re-applied 3 times in total with no success !!!.
    Anonymous 42789 Replies Flag this Response
  • Great advice. Once a person understands what they have, they then begin the journey to wellness and regaining homeostasis in our bodies. The problem is the illness disrupts our internal balance, throwing it out of kilter.Traditional medicine will treat symptoms but at a high price paid by internal organs such as liver, kidneys(the filters) as well as the wallet$$$$$$$$Herbal supplements, vitamins and minerals are giving patients relief of symptoms without casuing further damage to internal organsEating organic/raw is also helping patients100% of CFS patients are allergic to wheat. many are allergic to several things, accounting for many physical symptoms/pain(inflammmatory response)Non-traditional therapies are what patients express relief from symptoms as they take an active roll in healing from this illness.Therapies as mentioned above...NAET, Reiki, Bioset therapy, Accupuncture, ect...Western Civilization is so quick to disregard these therapies, referring to them as quackery. Many have been around for centuries. Some are new and have been born out of a desperate need for humanity to get back to being healthy, happy and whole.All of this information is priceless. The www stretches infinite. Research helpful information and use it to heal yourself, from the inside out.
    Anonymous 42789 Replies Flag this Response
  • Dear Chris SImpson, please know that many of us who have been diagnosed with CFS/ME did not all have the healthiest of childhoods. If this is vaccine related, it would make sense as most babies recieve vaccines shortly after birth. The chronic application of vaccines on top of vaccines over time, appears to have a layered effect as far as intensity, frequency and onset of symptomsAre you from UK? You must know already that there are 250,000 people in UK already diagnosed with ME.What do you do for a living?healthcare?teacher?student?can you trace symptoms backwards to beginning?even early childhood?when did they become more severe?
    Anonymous 42789 Replies Flag this Response
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  • It is interesting reading here about the possible causes of C.F.S/M.E from vaccines. I have had chronic fatigue type symptoms that have been undiagnosed now for years. I am 40 this year and have lived a miserable existance with this condition which as far as I can remember I have suffered far back into childhood with no time of good health, so I dont fit into the category of C.F.S/M.E!!!. Nor do I suffer the joint pains often associated with these conditions.I would therefore value any opinion as to what this could be and i would value any knowledge od specialist practioners in the U.K which might be able to throw light on the matter. I too am having immense difficulties getting disability benefits here as getting D.L.A is almost impossible, I have re-applied 3 times in total with no success !!!.Find a NAET certified person- a person with advanced NAET studies. This person can help your brain get the right feed-back, even if you were born like this- my case.Please also try Reiki, as it brings healing in many levels.Best.
    Eatafruit78 960 Replies Flag this Response
  • Research information on mycoplasma. It is does not occur naturally. It is the underlying factor in MOST diseases. Below is a list. Systemic Mycoplasma Infections are found in patients with: Gulf War Syndrome, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Fibromyalgia, Lyme Disease, Rheumatoid Arthritis, Systemic Lupus Erythematosus, Scleroderma, Sjogren's Syndrome, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Cystic Fibrosis, Asthma, Respiratory Distress Syndrome, Pneumonia, Bronchitis, Inflammatory Bowel Disease, Sarcoidosis, Wegener's Disease, Kikuchi's Disease, Leukemia, Alzheimer's Disease, Autism, Infertility, Stevens-Johnson Syndrome, and Acquired Immune Deficiency Syndrome, Hypercoagulation, Heart Disease, Stroke and Cancer.
    mommy cat 1654 Replies Flag this Response
  • Ask your doctors to do a polymerase chain reaction test if available in UK It is testing for mycoplasma infection which seems to be the underlying cause of many diseases and symptoms. It's a good place to start. Many have alot of symptoms and don't think they have CFS because they do not have FATIGUE. Perhaps it is not CFS but a similar disease also caused by a mycoplasma infection. Hope you are well....mommy cat
    mommy cat 1654 Replies Flag this Response
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