Discussions By Condition: I cannot get a diagnosis.

Cause of changes in liver function ?

Posted In: I cannot get a diagnosis. 6 Replies
  • Posted By: Anonymous
  • April 27, 2008
  • 06:47 PM

My Doctor has been running blood tests for somewhile now and he says that although he cannot say what is causing it my liver function is going up and down and up and down. He asked me whether I drink, but I dont .
Any ideas what could be causing this ?.

John P

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6 Replies:

  • There are many causes. Do you have any symptoms you can share?
    Anonymous 42789 Replies Flag this Response
  • There are many causes. Do you have any symptoms you can share?Yes. I had bloated stomach and in right side of groin. Doctor diagnosed Hernia. Went to hospital and had that done and they took out enlarged lymph node for biopsy. Biopsy was all clear. (by way I had CT scan whilst in hospital and then week later barium meal and xray).THEN 2 weeks or so after coming out of hospital, feeling fine but then I noticed that in the morning upon waking (not during day) my eyes were very red and blood shoot and looked glazed. Took about an hour or so after getting up and they changed back to normal. I also experienced some lethargy getting up, more than usual. Other thing I noticed was that even under only a warm shower my face would go very red in colour, NEVER has it done that before. Also if I rub finger across my skin anywhere it goes red, as if the blood is at the surface of skin and showing more easily the red colour.Then i noted the inside back of my throat and tonsils were red but not sore. Progressively I then notice I had a red neck also and blotchy red on top of chest. Then a pink hue to my arms and legs as if I had been in the sun but had not been. Also noted the corners of my eyes started to look dar and bags under eyes which I have never had before. I can say that I have discovered there is quite heavy mould and mould spores in this flat I am in .That MAY be causing a reaction as I am allergic to many things like pollen.Then Doctor started many ,many blood tests for things like Hep C, Hep A, HIV etc etc etc and all that he could find so far is that my liver function is going up and down and is not static. He has now tested me for Aspergillus and Aflatoxin which I await result of, but even so I am wondering what could be causing LT liver function to be uplifted and then go down again on next month ??.ThanksJohn P
    Anonymous 42789 Replies Flag this Response
  • As so many others you have very unspesific symptoms. There are a number of things that can cause your LT's to fluctate. Also the different types of enzymes point to different things. AST, ALT, SGOT, SGPT, and GGT and Alkaline Phosphatase are abbreviations for proteins called enzymes which help all the chemical activities within cells to take place. Injury to cells release these enzymes into the blood. They are found in muscles, the liver and heart. Damage from alcohol and a number of diseases are reflected in high values. Alkaline phosphatase is an enzyme found primarily in bones and the liver. Expected values are higher for those who are growing (children and pregnant women) or when damage to bones or liver has occurred or with gallstones. Low values are probably not significant. GGT is also elevated in liver disease, particularly with obstruction of bile ducts. Unlike the alkaline phosphatase it is not elevated with bone growth or damage. AST/SGOT , ALT/ SGPT are also liver and muscle enzymes. They may be elevated from liver problems, hepatitis, excess alcohol ingestion, muscle injury and recent heart attack. LDH is the enzyme present in all the cells in the body. Anything which damages cells, including blood drawing itself, will raise amounts in the blood. If blood is not processed promptly and properly, high levels may occur. If all values except LDH are within expected ranges, it is probably a processing error and does not require further evaluation. Bilirubin: is a pigment removed from the blood by the liver. Low values are of no concern. If slightly elevated above the expected ranges, but with all other enzymes (LDH, GOT, GPT, GGT) within expected values, it is probably a condition known as Gilbert’s syndrome and is not significant CPK is an enzyme which is very useful for diagnosing diseases of the heart and skeletal muscle. This enzyme is the first to be elevated after a heart attack (3 to 4 hours). If CPK is high in the absence of heart muscle injury, this is a strong indication of skeletal muscle disease Also you need to keep in mind that the liver is the largest organ in the body and it has a unique way of healing itself. That alone might be cause of fluctating enzyme levels. Hope this helps... Kiera
    Anonymous 42789 Replies Flag this Response
  • KieraThanks for the info I shall try and digest it all now. Let me say that if I was asked what is the most noticeable symptom that I have, I would say it is that I have DRY eyes and it is dark in the corner of each eye ,and it never has been like that before middle to end of of February in my life. It is noticeable and I think that hopefully may point to what is wrong ?. Could it be toxins produced by the mould spores that are causing this, and causing the red eyes ?. The other pointer is that during the day, when I have the windows open and am up and about I have no feeling of symptoms, but when I go to bed and in the morning (lying down maybe ???) I then get the symptoms and have heavy eyelids and red eyes.ThanksJohn PAs so many others you have very unspesific symptoms. There are a number of things that can cause your LT's to fluctate. Also the different types of enzymes point to different things. AST, ALT, SGOT, SGPT, and GGT and Alkaline Phosphatase are abbreviations for proteins called enzymes which help all the chemical activities within cells to take place. Injury to cells release these enzymes into the blood. They are found in muscles, the liver and heart. Damage from alcohol and a number of diseases are reflected in high values. Alkaline phosphatase is an enzyme found primarily in bones and the liver. Expected values are higher for those who are growing (children and pregnant women) or when damage to bones or liver has occurred or with gallstones. Low values are probably not significant. GGT is also elevated in liver disease, particularly with obstruction of bile ducts. Unlike the alkaline phosphatase it is not elevated with bone growth or damage. AST/SGOT , ALT/ SGPT are also liver and muscle enzymes. They may be elevated from liver problems, hepatitis, excess alcohol ingestion, muscle injury and recent heart attack. LDH is the enzyme present in all the cells in the body. Anything which damages cells, including blood drawing itself, will raise amounts in the blood. If blood is not processed promptly and properly, high levels may occur. If all values except LDH are within expected ranges, it is probably a processing error and does not require further evaluation. Bilirubin: is a pigment removed from the blood by the liver. Low values are of no concern. If slightly elevated above the expected ranges, but with all other enzymes (LDH, GOT, GPT, GGT) within expected values, it is probably a condition known as Gilbert’s syndrome and is not significant CPK is an enzyme which is very useful for diagnosing diseases of the heart and skeletal muscle. This enzyme is the first to be elevated after a heart attack (3 to 4 hours). If CPK is high in the absence of heart muscle injury, this is a strong indication of skeletal muscle disease Also you need to keep in mind that the liver is the largest organ in the body and it has a unique way of healing itself. That alone might be cause of fluctating enzyme levels. Hope this helps... Kiera
    Anonymous 42789 Replies Flag this Response
  • What medications have you been taking? Any scripts or OTC?What are your stools like? How frequent?Best wishesDOM
    acuann 3080 Replies Flag this Response
  • What medications have you been taking? Any scripts or OTC?What are your stools like? How frequent?Best wishesDOMHelloJust prior to going into hospital until two days after coming out of hospital I was on course of Amoxycllin and another antibiotic for tooth infection.Also on steroid inhaler (Beclotide) and Ventolin .Thats all. Lot of vitamins as usual. I must say that for short while after coming out of hospital there was a kind of strange smell from stools and was not same consistency as usual but after week or so that seemed to go. Once or twice a day empty bowels and no pains at all. Hernia scar has healed nicely and no probs there. Only thing that crosses my mind is I was on last day given a plastic bowl of water to use to wash my face with and then she put bowl back behind bed. I then thought to myself "who has used that before me ???????" Thats about it. Symptoms are not crippling but inconvenient and the eyes are the thing I need to sort out as they are not looking right and are dark in corners and dry and something must be causing that. The red/pink skin also concerns me with the red eyes in morning. Could this be an allergic reaction I wonder ?.John P
    Anonymous 42789 Replies Flag this Response
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