Discussions By Condition: Gastrointestinal conditions

Small intestine villus destruction

Posted In: Gastrointestinal conditions 1 Replies
  • Posted By: curemyreed
  • October 15, 2009
  • 03:33 AM

Is there something OTHER THAN celiac disease which would cause extensive destruction and damage to the villi of the small intestine?

Upper GI endoscopy of my 14-year-old son showed reflux esophagitis, hiatal hernia, and severe erosive gastritis. Child does not take any medications so the erosive gastritis could not be from NSAID use. Biopsy of various areas of the stomach showed lymphocytic gastritis (rare) mixed with reactive gastritis. Biopsy of stomach tissue was negative for H. pylori. Biopsy of the duodenum was negative for celiac disease. Previous blood tests (antibodies & genes) were negative/low risk for celiac disease.

Pill cam endoscopy of the small intestine showed long sections devoid of villi along with inflammation, but no ulceration. The lack of ulceration led the GI doc to rule out Crohn's disease. The damage/destruction of so much of the villus of the small intestine led him to make a diagnosis of celiac disease despite the negative blood tests and duodenal biopsy. However, he noted that he was not familiar with the lymphocytic gastritis as it is so unusual.

Wondering what if any other conditions could cause a widespread loss of the villus of the small intestine.....does anyone know?


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