Discussions By Condition: Eye conditions

Treatment options for POHS

Posted In: Eye conditions 2 Replies
  • Posted By: Anonymous
  • April 30, 2006
  • 02:17 AM

I'm not really expecting an answer to this since this is the first post, but what the ***l???

A friend of my father's was recently diagnosed with presumed ocular histoplasmosis syndrome. I'm hoping to go to med school in a couple years and my father asked me to look into it. Prior to today, I knew nothing about it.

The friend is currently scheduled to have photocoagulation and Visudyne treatment on Monday.

When I first started reading about POHS, the first thing I thought when I came across the fact that the vision loss is due to choroidal neovascularization (CNV) was that it would probably be a good candidate for treatment with Avistan.

Avistan is a fairly new cancer drug and its only approved use is for colorectal cancer, but it's an anti-angiogenesis inhibitor, which means it prevents new blood vessels from being created. Neovascularization is simply angiogenesis in the tissues of the eye.

So I did a little more research and found out that there have been some small studies using Avistan to treat age related macular degeneration (ARMD or AMD). AMD appears to operate in more or less the same manner, doing its damage via CNV. The treatment with Avistan has been very promising with about 40% completely reversing the damage, 30% having significant improvement and the rest not getting worse, which is something...

So, I'm wondering if anyone knows whether there are any studies using Avistan for POHS and if so, who is doing them? Otherwise, does anyone know why POHS might not be treatable with Avistan?

Thanks... I'm not expecting a response, but thought it was worth asking.


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2 Replies:

  • Hi,I would like to start by saying i am not a doctor. I started having problems with OHS back in March 05. I only had blurred vision in the right eye, and was treated with photodynamic therapy. I went back several times, 2 treatments over the next few months. The PDT was the only available treatment as the OHS was in the center of my right eye. In March of 06, with only some slight vision loss in the right eye, i went to Phoenix,AZ. During the flight apparently i had 2 ruptures in both eyes,caused by OHS. My current vision in my right eye is 20/400 and i believe 20/100 in the left. It has spread very rapidly and i am afraid i am about to lose my eyesight completely.Every doctor has experimental procedures they have mentioned but i don't wish to be a guinea pig. Most doctors just keep referring me to other doctors like i'm the elephant man. I need viable info on good doctors in the Tampa,Fl area. I have only been here a month and i am having a hard time getting in to a dr.'s office any info is greatly appreciated.
    Anonymous 42789 Replies Flag this Response
  • Hi. I was diagnosed with POHS in April 2006. At this time I have had approx 5 injections of Avastin (1 every 6 weeks) and at last exam, the bleeding in the back of my eye has been greatly reduced. My M.D. told me from the beginning that the chances of my vision coming back are slim to none, but the avastin has done what it was supposed to do.
    Anonymous 42789 Replies
    • January 20, 2007
    • 03:28 AM
    • 0
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