My girlfriend’s father has a 16-years history of meningiomas and now he undergoes multiple metastasis in lung and spine two month ago. The details is at the end.
1 I want to know which drug is effective in treating Megnigioma.
2 Some other specialists told me that Chemotherapy has been generally reserved for meningioma recurrences. I know some research focus on Hydroxyurea, interferon, Vatalanib and so on. Why some result support some drugs are effective, but other result support the same drugs are not? By now has there been any research which can give a sure result that some drug is against meningiomas?
3 There is no blood-brain barrier outside the metastatic cancer. Can this reason cause some drugs is more effective in treating the metastatic cancer than the original cancer? If there is, do we know this drugs?
In a word, we want to learn the best effective drugs for meningioma and metastases from meniongioma as possible as we can.
Tanks in advance
PS.: The detail of the patient
My girlfiend's father developed meningioma in 1990 and have undergone five craniotomies for resection. The nearest resection was in March 2006. He underwent irradiation of whole brain with 4000 cGy and Gamma knife with the marginal does of 13 Gy. Lung metastases and bone metastases were found in May 2006. Then he received irradiation of lung in May 2006.
the pathological report is :
In January 2005, the max length of the meningioma is 11cm. Histochemical report is : :GAFP(+-) vim(+) EMA(+) PCNA(-).. The pathological report is: eningiothelial meningioma Necrosis(+) Mitosis(+) <4/10hpfs Peritumoral edema(+)
In March 2006, the max length of the meningioma is 8cm. The pathological report is: Meningotheliomatous ,WHO Grade II, with mitosis and invasion.
The lung puncture report is : EMA(+), Vimentin(+), CK(AE1/AE3)(-), CK7(-), CK17(-).
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