I have had classic ITP for the last 9 years, which has been controlled using prednisone (5-10 mg, occasionally tapering from 60).
Last July I began having various neurological symptoms like numbness in my scalp, outer fingers/hands and feet, and right cervical myelopathy which was accompanied by mild pancytopenia. Going back on 60 mg and IVIG caused the panyctopenia to resolve within a week or so and the neurological symptoms have mostly faded since then.
At the beginning of March the pancytopenia returned in a more severe form (platelets down to 3, WBC's down to .8 within a few weeks, and RBC's dropping down to 6). I have been receiving platelet transfusions twice weekly and blood transfusions biweekly along with neupogen and procrit.
Bone marrow biopsy results were as follows;
No megakaryocytes seen
Some slides hypocellular
Some slides hypercellular w/ shift towards immature (may be effect of neupogen)
Lymphoid aggregates (seen in autoimmune)
Cytogenetics and chromosomes appear normal
The doctors do not believe that I am aplastic or mds, but have no explanation beyond some vague autoimmune process.
Has anyone ever heard of something like this?
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