Discussions By Condition: Blood conditions

Platelet Inhibitor Adrenaline Disorder

Posted In: Blood conditions 2 Replies
  • Posted By: tinkerbelle_503
  • November 29, 2010
  • 09:35 AM

I am a 27 year old woman & was diagnosed with Platelet Inhibitor Adrenaline Disorder in November 2008 after suffering from spontaneous bleeds into my knees & ankles. I am currently being managed by a lovely haematologist on Tranexamic Acid daily, platelet transfusions during bleeds if necessary & pain relief to deal with the pain from both the bleeds & the arthritis that has started due to the blood eating away at my joints.
My question: has anyone ever heard of this dysfunction?
I can only find 1 article on google that was written in 1983 that only suggests it may exsist.
I'd be so truly grateful if someone could give me some information & would LOVE to get in touch with someone else that has Platelet Inhibitor Adrenaline Disorder.

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2 Replies:

  • Ok, seriously???No one can tell me anything???I live in Australia and I thought by asking people that live in a country as large as the United States, surely someone would know something?!Wow, I really feel alone on this one :(
    tinkerbelle_503 4 Replies
    • January 31, 2011
    • 01:49 AM
    • 0
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  • Ok, seriously???No one can tell me anything???I live in Australia and I thought by asking people that live in a country as large as the United States, surely someone would know something?!Wow, I really feel alone on this one :(Hi Tinkerbelle,this may be of interest - Platelet Inhibitor Adrenaline Disorder was only first described in the 1980s as something not seen before. There is a large number of agents required for platelet aggregation and adrenaline is one of them – that agents that signal/enable them to gather to form clots. Patients basically have bleeding problems as they may have sufficient platelets but do not make clots easily.The platelets have an adrenaline receptor defect on them which inhibits/stops them receiving the signal and thus their ability to aggregate (form a clot). Some times it is due to an impaired receptor and sometimes a congenital defect. The result is the same with easy bruising/bleeding into joints etc. There is a genetic defect associated with it on the (gene gamma2 AR locus 10q24-q26). This is a pretty rare rare platelet disorder among a cluster of rare platelet disorders.
    Anonymous 42789 Replies Flag this Response
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