Discussions By Condition: Blood conditions

enlarged red blood cells

Posted In: Blood conditions 29 Replies
  • Posted By: Anonymous
  • June 7, 2007
  • 04:01 AM

i have enlarged red blood cells...have had all kinds of tests and no i am not anemic...i have been going to a hemotologist oncologist for 2 yrs now... still they do not know why... anyone have any ideas ? thanks

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29 Replies:

  • I have the same problem. My gastro doc said I had pernicous anemia; so for 10 years I have had monthly b-12 injections. I just had my first complete physical (stress test, hearing, blood work, xrays...the works) two weeks ago. All of my folic, folates and such are normal...but I have a very high red blood cell count (enlarged red blood cells) - now I am being told I don't have any anemia. My liver function is great and I don't drink so this is not from heavy drinking either. I don't know about you, but I am exhausted most of the time and I have lost weight down to unhealthy levels...but get it back up for about 3 - 6 months and then down it goes again.If you have received any helpful info, I would sure appreciate hearing from you...and if you have any other symptons I would like to hear about them.Thanks...
    Anonymous 42789 Replies
    • September 7, 2007
    • 03:26 AM
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  • are enlarged rbc's found on the RDW (Red Cell Distribution Width), which is part of a standard CBC?? If so, my RDW was high and no one addressed it.
    Anonymous 42789 Replies
    • September 13, 2007
    • 01:38 PM
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  • Enlarged RBCs can be due to a multitude of causes including B12 (as mentioned) and folate deficiency. Are you a vegetarian? B12 is usually contained in meat and eggs so if your diet doesn't include these, this may be the problem. Other possibilities are liver disease, medications such as Dilantin (for seizures), myeloproliferative disorder (abnormal bone marrow production of RBCs), and sometimes thyroid problems. An internist should see you in order to rule these diagnoses out. sangelo, MD
    Anonymous 42789 Replies
    • September 13, 2007
    • 04:19 PM
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  • Oh and a couple of other things: Alcohol abuse can also cause enlarged RBCs. Any alcohol intake over 2 drinks (woman) and 3 drinks (man) per day can lead to bone marrow damage and increased RBC size. Also, if you recently became very anemic from major blood loss or experience significant blood loss on a regular basis (e.g. menstruation), this could also lead to enlarged RBCs. Reticulocytes, which are bigger than RBCs, are basically "baby" RBCs. They are pumped out in large volumes when the bone marrow is trying to compensate for blood loss. When the laboratory analysis occurs, the machine does not separate the reticulocytes from the mature RBCs and as such, the larger size of the reticulocytes are factored in. Good luck and I hope this helps. sangelo, MD
    Anonymous 42789 Replies
    • September 13, 2007
    • 04:27 PM
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  • My RDW was 16.3 (11.0-15.0 is the range, I believe). I have never been called anemic, but I know my hematocrit runs around 34% (menstruating female).
    Anonymous 42789 Replies
    • September 25, 2007
    • 03:48 PM
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  • I have the same problem. My gastro doc said I had pernicous anemia; so for 10 years I have had monthly b-12 injections. I just had my first complete physical (stress test, hearing, blood work, xrays...the works) two weeks ago. All of my folic, folates and such are normal...but I have a very high red blood cell count (enlarged red blood cells) - now I am being told I don't have any anemia. My liver function is great and I don't drink so this is not from heavy drinking either. I don't know about you, but I am exhausted most of the time and I have lost weight down to unhealthy levels...but get it back up for about 3 - 6 months and then down it goes again.If you have received any helpful info, I would sure appreciate hearing from you...and if you have any other symptons I would like to hear about them.Thanks...Ditto. Do you have muscle weakness? Stomach problems?
    Anonymous 42789 Replies Flag this Response
  • Dr. Sangelo, I was also recently told I have enlarged red blood cells. My doctor followed up with a B12 and folate test since I do not drink. She said that test was normal. I've never taken seizure meds. The only meds I'm on are birth control and a multivitamin. My thyroid levels were normal. Does that only leave liver disease, or can red blood cells be enlarged for no reason?Enlarged RBCs can be due to a multitude of causes including B12 (as mentioned) and folate deficiency. Are you a vegetarian? B12 is usually contained in meat and eggs so if your diet doesn't include these, this may be the problem. Other possibilities are liver disease, medications such as Dilantin (for seizures), myeloproliferative disorder (abnormal bone marrow production of RBCs), and sometimes thyroid problems. An internist should see you in order to rule these diagnoses out. sangelo, MD
    Anonymous 42789 Replies
    • August 12, 2009
    • 07:59 PM
    • 0
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  • Dr. Sangelo, Thank you so much for mentioning anti-seizure drugs. I've had enlarged RBCs for a while now but my B12, folate, and thyroid levels are all good. I do take Topamax however for migraines...that might explain it! I'll talk to my doctor about it (she's new for me) - thanks again...
    Anonymous 42789 Replies
    • December 18, 2009
    • 08:11 PM
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  • Ditto. Do you have muscle weakness? Stomach problems?I have stomach problems, and muscle weakness as well as the inability to see any change in muscle growth - I see atrophy. I have been told I have enlarged red blood cells and I am tired and cold all of the time.
    Anonymous 42789 Replies
    • January 19, 2010
    • 01:56 AM
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  • i have enlarged red blood cells...have had all kinds of tests and no i am not anemic...i have been going to a hemotologist oncologist for 2 yrs now... still they do not know why... anyone have any ideas ? thanksI was told by a doctor several years ago that people of Mediterranean decent are likely to have larger red blood cells than average. I am italian and so he said this was nothing to worry about.
    Anonymous 42789 Replies
    • February 9, 2010
    • 03:25 AM
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  • are enlarged rbc's found on the RDW (Red Cell Distribution Width), which is part of a standard CBC?? If so, my RDW was high and no one addressed it.I was in the medical field for over 15 years. I also mave a high RDW. I spoke with my hemotologist/oncologist and after a DNA screen, I was diagnosed. RDW width can possibly be due to the new red blood cells are being releaed into the blood system pre-maturely. My specific diagnosis was a rare genetic blood disorder called "MTHFR". This is only one disorder and /or diagnosis that can cause high RDW values. I would suggest that you ask your Doctor about a full DNA scan. The scan may possibly reveal the source off your high RDW value.
    Anonymous 42789 Replies Flag this Response
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  • I recently seen doc for my increased bp. I have for years run in 160/ high 90's for as long as I can remember, recently my bp is more like 140/170 over 100/110. My Dr is redoing liver tests etc and antimitochondrial was also written on the form as a specific test (will check that in a min ) I've been started on 5mg atenalol once a day until these further tests arrive, he stated his drug of choice would be propanalol but this would interfere with the results so these will be changed I guess. He's also going to send me for a liver scan and I believe he wishes me to do a 24hr urine sample (only guessing that cos he said he'd need to order a special pot!!)Yes always quite fatigued these days (Whats the norm?). Don't drink(my wife an I may share a bottle once or twice a month) ex smoker (recent) 20yr habit, ex squaddie served in the 1st gulf war, lots of vaccinations etc,2 episodes of Glandular fever about 1.5yrs apart from about 16/18 which really really hit me hard.Any ideas thanks for reading
    Anonymous 42789 Replies Flag this Response
  • I also have enlarged red blood cells, I quit drinking for 4 months and the test still came out low B12 and folic and the red blood cells are still enlarged. Over a year ago, I lost over 30 pounds, lost all my muscle mass, get lightheaded easily and feel fatigued. I was also once on monthly B12 injections for a year. Now I take folic and B12 tablets, to no avail. My diet is fine and I haven't been able to get above 100 pounds. I was also told that I have large amounts of stomach acid and I take levothyroxizine for hypothyroidism. I was exposed to toxic mold and animal feces while helping clean up water damage in a house, before the weight and muscle loss happened. I don't know if this relates or not. My doctor said she is going to consult with a hemotologist, but that will take months. If I get any answers I'll let you know.
    Vickie 4 Replies Flag this Response
  • i have had about 30 blood tests over the last 2 years that have all showed enlarged red blood cells i dont drink any alchol im not anemic my vitamin levels r normal but i do have crohns disease and regularly lose blood from my bowel so maybe this could be the cause of it
    Anonymous 42789 Replies Flag this Response
  • i have had about 30 blood tests over the last 2 years that have all showed enlarged red blood cells i dont drink any alchol im not anemic my vitamin levels r normal but i do have crohns disease and regularly lose blood from my bowel so maybe this could be the cause of itFrom Vickie: I have had a colonoscopy done and it did not show any problems regarding crohns disease. Thanks for the tip, though.
    Vickie 4 Replies Flag this Response
  • I have the same problem. My gastro doc said I had pernicous anemia; so for 10 years I have had monthly b-12 injections. I just had my first complete physical (stress test, hearing, blood work, xrays...the works) two weeks ago. All of my folic, folates and such are normal...but I have a very high red blood cell count (enlarged red blood cells) - now I am being told I don't have any anemia. My liver function is great and I don't drink so this is not from heavy drinking either. I don't know about you, but I am exhausted most of the time and I have lost weight down to unhealthy levels...but get it back up for about 3 - 6 months and then down it goes again.If you have received any helpful info, I would sure appreciate hearing from you...and if you have any other symptons I would like to hear about them.Thanks...From Vickie: Before the weight and muscle loss, I had redness and bruising on my fingertips, my blood tests showed high rbc's, white blood cells and platelet counts were also high. Now, just the wbc's are slightly elevated. Another problem I have is that my feet hurt and I have constant shoulder pain. On the plus side, I have not had a cold or flu in over three years. Hope this helps!
    Vickie 4 Replies Flag this Response
  • I have had Enlarged red blood cells since i can remember. I have been tested for multiple dis eases. I know that it is not cancer, or my liver. I know its not from anemia. All the drs I have gone to dont have a clue why. They dont seem concerned either.Its kinda cool, in highschool in science class, I was the one whos blood could be easily seen in the microscope! Later my son and I were looking at our red cells under a microscope and I still have the large cells!I also have had anemic type symptoms all my life. This is not the cause so, what is?
    Anonymous 42789 Replies
    • August 11, 2010
    • 09:05 PM
    • 0
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  • I was diagnosed the blood condition Microcytosis. The most I drank all of my life is about two glasses of red wine. I have never been drunk. I do not drink hard liquor.
    Anonymous 42789 Replies
    • October 4, 2010
    • 03:22 PM
    • 0
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  • I was diagnosed the blood condition Microcytosis. The most I drank all of my life is about two glasses of red wine. I have never been drunk. I do not drink hard liquor.What kind of symptons led to this diagnosis?
    Vickie 4 Replies
    • October 4, 2010
    • 11:04 PM
    • 0
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  • My mom is 73 & has enlarge red blood cells. She has been very sick for a month + now. She spend all day in bed or in a electric lounge chair. She is so week she can barely walk, she can't walk without a walker, she has lost 25+pounds in the last 4 months & is pretty much skin & bones. She has no appetite, & complain of stomache pain every time she eats. Her muscle have seriously degenerated, she is often confused but she has had low sodium blood tests. She sometime slurs her speach, she has coordination problems, & she is incontinent. She is tacycardic/ has a heart rate over 100 most of the time & when she was dehydrated it was shooting up over 200. She has had a cough that makes her gag but only produce clear mucus. She was in ER observation for 3+ days they did CT's of her head, chest, & abdomin, X-rays of her chest, back, a hip she broke 17 years ago. Did a variety of blood & urine tests, including colon cancer marker test. All they came up with was slightly low sodium, slightly off liver something, & the enlarged red blood cells. They gave her IV fluids & called it dehydration & sent her home. She had breast cancer 2005-2007. She had 3 rounds of chemo, 3 radiation treatments, & both breast removed. Since the mastectomy she has had a high red blood cell count but her Oncologist/Hemotologist said it never got high enough to treat her for buy taking a pint of blood out. Last week he gave her a shot of B12, a folate infusion, & a cortasol infusion. It didn't help. The doctors are asking me what I want them to do/where to look next. Can anyone help me here. I am disabled myself & my dad is 72 & not well himself & we are her only caregivers. I have been doing all the housekeeping, laundry, shopping, bill paying/manage their finances, manage their insurance issues, order, pick up, & put out their meds, etc.. since mom got sick in 2005. Dad & I are both killing ourselves trying to take care of her, waiting on her hand & foot so to speak, changing diapers & wet bed linens, lifting & bathing her. The visiting nurse just checks her vitals & leaves & will probably discharge her today. A physical therapist comes twice a week but mom doesn't do her exercises on her own & thats just another thing dad & I have to help her with so it does't get done because we are so warn out. Any help would be greatly appeciated. thanks
    Anonymous 42789 Replies
    • October 11, 2010
    • 03:13 PM
    • 0
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