Discussions By Condition: Blood conditions

CML, AML, or Myelodysplastic syndromes

Posted In: Blood conditions 1 Replies
  • Posted By: Doctor Ali
  • June 17, 2011
  • 04:28 PM

Hello everyone!

I'm currently a Med student studying for the Boards. I am healthy young male. I just have a case to solve. Believe me this isn't a real patient's case; we just make up symptoms and see what type of results do we get. It's thinking/learning process that we do. So, here's a case:

1. 32 year old female with 2 children
2. Had issues with her spleen during her second child birth as well as extreme edema
3. No alcohol, no drugs, no BCP, no nothing

1. Easy Bruising and weird purple marks on her skin
2. Skin irritations and infections
3. Easy to catch ill, slow to recover
4. Fatigue
5. Headaches
6. Weight gain

1. Low WBC production, under 5,000uL
2. Low RBC production, don't know how low
3. Average life of her RBCs is 60 days

What I'm looking for? CML, AML, or Myelodysplastic syndromes?

Thank you so much!!!

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1 Replies:

  • Entities in the differential diagnosis of AML include those where: The blast count is borderline at approximately 20 percent (eg, in myelodysplastic or myelodysplastic/myeloproliferative syndromes); blasts can be elevated in regenerating bone marrow after chemotherapy or those altered by growth factor effect. The blasts are difficult to demonstrate as being myeloid (eg, ALL with co-expression of myeloid markers, in biphenotypic leukemias, and in non-hematopoietic tumors (perhaps most commonly small cell carcinomas of the lung) where the characterization of the cells infiltrating the marrow can be dependent on immunophenotyping using antibodies specific for solid tumors. Erythroid elements are prominent and mimic erythroleukemia (eg, vitamin B12 and folate deficiency). There are 20 percent or more blasts that are clearly myeloblasts but which actually represent transformations of other chronic myeloid disorders (eg, chronic myeloid leukemia in blast crisis, or myeloproliferative or myelodysplastic neoplasms transforming to AML).
    ronny27 47 Replies Flag this Response
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