Top end of the scale for an adult IgE reading is around 150. Mine is 7,028. Tried Xolair for 4 years but had to stop it. IgE only went down to 650 while on it. I have recurrent sinus infections. I've had a severe Staph Aureus Ifx, Pneumonia (650 ml via thoarocentesis), MVP with regurg, myalgia's and arthralgia's, fatigue, EBV, CMV (non-sexual), pancreatitis, endometriosis, fibroids, rupturing ovarian cysts, nabothian cysts, biopsied lymphnodes x's 2 revealing a moth-eaten pattern, not toxoplasmosis though, multiple knots, none cystic, some kind of vascular condition; severely cold-intolerant, had to move South! No fibromyalgia, no CFS. Allergy to foods, animals, environmental. Done IVIG to boost immune system so abx work better/boosted and took away arthralgia's and myalgia's. Just wondering if any other unlucky person is a mess like I am with no dx! Be well my friends!